Interplay between gut microbiota, bone health and vascular calcification in chronic kidney disease

Rodrigues, Fernanda Guedes; Ormanji, Milene Subtil; Heilberg, Ita Pfeferman; Bakker, Stephan J. L.; Borst, Martin H. de

doi:10.1111/eci.13588

Cited by 26 publications

(21 citation statements)

References 148 publications

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“…SCFAs may have immunomodulatory effects. Inflammatory cells, such as neutrophils, macrophages, dendritic cells, and T cells are responsive to SCFA treatment, which is consistent with the anti-inflammatory role of SCFAs in a wide range of inflammatory diseases and the reduction of VC [ 30 , 31 ].…”

Section: Discussionsupporting

confidence: 63%

“…Ruminococcus are gram-positive anaerobic bacteria belonging to the family Ruminococcaceae and the phylum Firmicutes, which are widely recognized for their capacity to hydrolyze and ferment many structural and storage polysaccharides to produce short-chain fatty acids (SCFAs), such as butyrate [ 28 , 29 ]. Recent studies found that SCFAs seem to contribute to the improvement of vascular phenotypes [ 1 , 30 ]. SCFAs may have immunomodulatory effects.…”

Section: Discussionmentioning

confidence: 99%

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Relationship between gut microbiota and vascular calcification in hemodialysis patients

Bao

Yang

et al. 2023

Renal Failure

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Introduction Vascular calcification (VC) is an independent risk factor for cardiovascular mortality in end-stage renal disease (ESRD) patients. The pathogenesis of VC is complicated and unclear. Uremic toxins produced by gut microbiota can promote VC. This study aims to identify the differences in gut microbiota between the different VC groups and the main bacteria associated with VC in hemodialysis (HD) patients in an attempt to open up new preventive and therapeutic approaches and define the probable mechanism for VC in HD patients in the future. Methods A total of 73 maintenance HD patients were enrolled in this cross-sectional study. According to the abdominal aortic calcification (AAC) scores, the participants were divided into the high AAC score group and the low AAC score group. High-throughput sequencing of the gut microbiota was performed and the results were evaluated by alpha diversity, beta diversity, species correlation, and model predictive analyses. Results The prevalence of VC was 54.79% (40/73) in the study. The majority of phyla in the two groups were the same, including Firmicutes , Actinobacteriota , Proteobacteria , and Bacteroidota . The microbial diversity in the high AAC score group had a decreasing trend ( p = 0.050), and the species abundance was significantly lower ( p = 0.044) than that in the low AAC score group. The HD patients with high AAC scores showed an increased abundance of Proteobacteria and decreased abundances of Bacteroidota and Synergistota at the phylum level; increased abundances of Escherichia-Shigella, Ruminococcus_gnavus_group, and Lactobacillus; and decreased abundances of Ruminococcus and Lachnospiraceae_NK4A136_group at the genus level ( p< 0.05). Escherichia-Shigella and Ruminococcus_gnavus_group were positively correlated with VC, and Ruminococcus, Adlercreutzia , Alistipes, and norank_f__Ruminococcaceae were negatively correlated with VC. Escherichia-Shigella had the greatest influence on VC in HD patients, followed by Ruminococcus and Butyricimonas. Conclusions Our results provide clinical evidence that there was a difference in gut microbiota between the different VC groups in HD patients. Escherichia–Shigella, a lipopolysaccharide (LPS)-producing bacterium, was positively correlated with VC and had the greatest influence on VC. ...

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Section: Discussionsupporting

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Relationship between gut microbiota and vascular calcification in hemodialysis patients

Bao

Yang

et al. 2023

Renal Failure

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“…In fact, the mineral bone disorder associated with CKD is characterised by one or more abnormalities in circulating minerals and their regulating hormones, bone abnormalities, and VC [ 21 ]. Mounting evidence indicates that the gut dysbiosis associated with CKD may be involved in the pathogenesis of bone–vascular axis [ 8 , 23 ]. Recent data suggest that an increased protein fermentation, and consequent uremic toxins production, decreased carbohydrate fermentation, vitamin K deficiency, and gut-derived inflammation may, alone or together, drive to a vascular and skeletal pathobiology in CKD patients [ 8 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

“…Mounting evidence indicates that the gut dysbiosis associated with CKD may be involved in the pathogenesis of bone–vascular axis [ 8 , 23 ]. Recent data suggest that an increased protein fermentation, and consequent uremic toxins production, decreased carbohydrate fermentation, vitamin K deficiency, and gut-derived inflammation may, alone or together, drive to a vascular and skeletal pathobiology in CKD patients [ 8 , 23 ]. Still, to our knowledge, there are currently no data on the putative association between blood microbiome and vascular calcification.…”

Section: Introductionmentioning

confidence: 99%

Vascular Calcification and the Gut and Blood Microbiome in Chronic Kidney Disease Patients on Peritoneal Dialysis: A Pilot Study

et al. 2022

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Vascular calcification (VC) is a frequent condition in chronic kidney disease (CKD) and a well-established risk factor for the development of cardiovascular disease (CVD). Gut dysbiosis may contribute to CVD and inflammation in CKD patients. Nonetheless, the role of gut and blood microbiomes in CKD-associated VC remains unknown. Therefore, this pilot study aimed to explore the link between gut and blood microbiomes and VC in CKD patients on peritoneal dialysis (CKD-PD). Our results showed relative changes in specific taxa between CKD-PD patients with and without VC, namely Coprobacter, Coprococcus 3, Lactobacillus, and Eubacterium eligens group in the gut, and Cutibacterium, Pajaroellobacter, Devosia, Hyphomicrobium, and Pelomonas in the blood. An association between VC and all-cause mortality risk in CKD-PD patients was also observed, and patients with higher mortality risk corroborate the changes of Eubacterium eligens in the gut and Devosia genus in the blood. Although we did not find differences in uremic toxins, intestinal translocation markers, and inflammatory parameters among CKD-PD patients with and without VC, soluble CD14 (sCD14), a nonspecific marker of monocyte activation, positively correlated with VC severity. Therefore, gut Eubacterium eligens group, blood Devosia, and circulating sCD14 should be further explored as biomarkers for VC, CVD, and mortality risk in CKD.

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“…The gut microbiome may act as a bridge between kidneys, aging and IS disorders ( 9 ). Microbiota evolves normally from newborn to elderly, as a result of epigenetic mechanisms, environmental factors, personal habits, nutrition, etc.…”

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confidence: 99%

Editorial: Immunosenescence and Immunoexhaustion in Chronic Kidney Disease and Renal Transplantation

et al. 2022

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Interplay between gut microbiota, bone health and vascular calcification in chronic kidney disease

Abstract: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

Cited by 26 publications

References 148 publications

Relationship between gut microbiota and vascular calcification in hemodialysis patients

Relationship between gut microbiota and vascular calcification in hemodialysis patients

Vascular Calcification and the Gut and Blood Microbiome in Chronic Kidney Disease Patients on Peritoneal Dialysis: A Pilot Study

Editorial: Immunosenescence and Immunoexhaustion in Chronic Kidney Disease and Renal Transplantation

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