Gut Microbiota and Immune Responses

Dong, Lijun; Xie, Jingwen; Wang, Youyi; Zuo, Daming

doi:10.1007/978-981-15-2385-4_10

Cited by 18 publications

(8 citation statements)

References 170 publications

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“…Increasing evidence shows that the gut microbiota is very sensitive to drugs, diet and environmental pollutants. 29,30 It has been shown that environmental pollutants can alter the biological composition and diversity of intestinal microbes in living organisms, leading to energy metabolism disorders, inadequate nutrient absorption, decreased immune system function, or other symptoms of poisoning. 31,32 Therefore, it is urgent to study the effect of cumulative exposure of M/NPLs on the GI tract and gut microbiota.…”

Section: Introductionmentioning

confidence: 99%

Perturbation of gut microbiota plays an important role in micro/nanoplastics-induced gut barrier dysfunction

et al. 2021

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Section: Introductionmentioning

confidence: 99%

Perturbation of gut microbiota plays an important role in micro/nanoplastics-induced gut barrier dysfunction

et al. 2021

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“…Therefore, we evaluated the effect of probiotic bacteria to stimulate the apoptosis mechanism in EJ138 bladder tumor cells. Furthermore, Lactobacillus are probiotic bacteria that could reinforce the immune system and are capable of shifting Th1 immune responses in infectious and cancer models [16].…”

Section: Discussionmentioning

confidence: 99%

Lactobacillus Acidophilus Cytotoxicity Effect and Apoptosis in Human Bladder Carcinoma Cells: An In Vitro Study

Taheri

Moazamian

Mahdavi

2021

Immuno

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Introduction: Anticancer effects of Lactobacillus acidophilus, as a probiotic bacterium, have been indicated in several studies. There are common therapeutic options for bladder cancer treatment; however, their side effects and recurrence of disease are considerable. Therefore, complementary medication is essential and it must be safe and effective. In the present research, we assessed the anti-tumor activity of Lactobacillus acidophilus (LB) on the bladder cancer cell line by evaluating the apoptosis mechanism. Materials and Methods: EJ138 bladder cancer cell line was provided and the cytotoxicity level of LB was evaluated with various concentrations after 24, 48, and 72 h. To evaluate the apoptosis effect, the gene expression of Bax, BCL2, and TNF-α was assessed using real-time PCR. Results: The optimum concentration of the cytotoxicity level was 12.5μg/mL at 24, 48, and 72 h. Bax expression was upregulated in tumor cells treated with LB alone and the mixture of LB and BCG (LB/BCG) as compared to the control group after 24 and 48 h. Also, the mRNA level of TNF-α increased in treated cells with LB and LB/BCG compared to the control group. BCL2 expression did not show a significant difference between experimental groups versus the control group. Conclusion: Our findings showed that LB has a synergistic effect with BCG through increasing apoptotic gene expression and TNF-α cytokine. Besides, at 48 h treatment, the apoptosis effect is more than 24 h. Thus, it seems that the mode of action of LB is time-dependent.

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“…The intestine is the main site of action of probiotics and the development of various targeted delivery systems has enabled probiotics to reach their designated sites and exert beneficial effects. Despite the fact that the mechanism has not been fully studied, several studies have confirmed that the defense function of the intestinal barrier, which is composed of intestinal epithelial cells, is enhanced when probiotics reach the intestine [ 79 , 80 , 81 ]. Adhesion of probiotics to the intestinal mucosa also increases, which is a favorable factor for the interaction between probiotic bacteria and the host during intestinal colonization [ 82 ].…”

Section: The Site Of Action Of Probiotics and Their Corresponding Dos...mentioning

confidence: 99%

Characteristics of Probiotic Preparations and Their Applications

Wang

Chen

Xia

et al. 2022

Foods

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The probiotics market is one of the fastest growing segments of the food industry as there is growing scientific evidence of the positive health effects of probiotics on consumers. Currently, there are various forms of probiotic products and they can be categorized according to dosage form and the site of action. To increase the effectiveness of probiotic preparations, they need to be specifically designed so they can target different sites, such as the oral, upper respiratory or gastrointestinal tracts. Here we review the characteristics of different dosage forms of probiotics and discuss methods to improve their bioavailability in detail, in the hope that this article will provide a reference for the development of probiotic products.

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Gut Microbiota and Immune Responses

Cited by 18 publications

References 170 publications

Perturbation of gut microbiota plays an important role in micro/nanoplastics-induced gut barrier dysfunction

Perturbation of gut microbiota plays an important role in micro/nanoplastics-induced gut barrier dysfunction

Lactobacillus Acidophilus Cytotoxicity Effect and Apoptosis in Human Bladder Carcinoma Cells: An In Vitro Study

Characteristics of Probiotic Preparations and Their Applications

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