Perturbation of gut microbiota plays an important role in micro/nanoplastics-induced gut barrier dysfunction

Qiao, Jiyan; Chen, Rui; Wang, Mengjie; Bai, Ru; Cui, Xuejing; Liu, Ying; Wu, Chongming; Chen, Chunying

doi:10.1039/d1nr00038a

Cited by 106 publications

(52 citation statements)

References 68 publications

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“…Thus, their potential effects on gut microbiota dysbiosis are an attractive proposal in need of verification. 28 It should be indicated that Drosophila has been proposed as a simple model to study the microbiome, 29 and perturbations of its microbiome can result in states of instability or disease in Drosophila. 30 The ingested PSNPLs can be subjected to interactions with midgut bacteria and with different intestinal enzymes, as well as with the acidic intestinal environment, potentially leading to decreases in their initial size; thereby, plastic particles can be eroded.…”

Section: Discussionmentioning

confidence: 99%

Hazard assessment of ingested polystyrene nanoplastics in Drosophila larvae

Alaraby

Abass

Domenech

et al. 2022

Environ. Sci.: Nano

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Section: Discussionmentioning

confidence: 99%

Hazard assessment of ingested polystyrene nanoplastics in Drosophila larvae

Alaraby

Abass

Domenech

et al. 2022

Environ. Sci.: Nano

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“…Jin et al described the breakdown of the epithelial barrier, gut microbiota dysbiosis, and impacts on the metabolic pathways in the microbial community in mice treated with MP particles [ 29 ] ( Figure 4 ). At the same time, Li et al [ 30 ] and Qiao et al [ 217 ] characterized similar effects upon treatment with MP particles ( Figure 4 ). Strikingly, Zheng et al reported that MP administration aggravated acute DSS colitis and increased intestinal epithelial permeability [ 31 ].…”

Section: Global Plastic Crisis—intestinal Consequences?mentioning

confidence: 64%

“…Several studies describe adverse effects on the gut microbiome, reduced mucus secretion, and damage of barrier integrity upon administration of MP particles. Li et al describe the reduction in regulatory T-cells (Treg) and Th17 cells, increased Toll-like receptor 4 (TLR4) downstream signaling, and IL1α expression, suggesting activation of pro-inflammatory cascades and translocation of bacterial products into the system [ 28 , 29 , 30 , 31 , 32 , 217 , 218 ].…”

Section: Figurementioning

confidence: 99%

The Intestinal Barrier—Shielding the Body from Nano- and Microparticles in Our Diet

Schwarzfischer

Rogler

2022

Metabolites

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Nano- and microparticles are an implicit part of the human diet. They are unknowingly ingested with our food that contains them as additives or pollutants. However, their impact on human health is not yet understood and controversially discussed. The intestinal epithelial barrier shields our body against exogenous influences, such as commensal bacteria, pathogens, and body-foreign particles and, therefore, protects our body integrity. Breakdown of the intestinal epithelial barrier and aberrant immune responses are key events in the pathogenesis of inflammatory bowel disease (IBD). Epithelial lesions might enable systemic translocation of nano- and microparticles into the system, eventually triggering an excessive immune response. Thus, IBD patients could be particularly vulnerable to adverse health effects caused by the ingestion of synthetic particles with food. The food-additive titanium dioxide (TiO2) serves as a coloring agent in food products and is omnipresent in the Western diet. TiO2 nanoparticles exacerbate intestinal inflammation by activation of innate and adaptive immune response. Because of serious safety concerns, the use of TiO2 as a food additive was recently banned from food production within the European Union. Due to environmental pollution, plastic has entered the human food chain, and plastic microparticles have been evidenced in the drinking water and comestible goods. The impact of plastic ingestion and its resulting consequences on human health is currently the subject of intense research. Focusing on TiO2 and plastic particles in the human diet and their impact on epithelial integrity, gut homeostasis, and intestinal inflammation, this review is addressing contemporary hot topics which are currently attracting a lot of public attention.

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“…Some authors have hypothesized that MPs could carrier and release phthalate esters into intestinal traits with consequential toxic effects ( 108 ). Also, MPs also can induce GM dysbiosis and specific bacteria alterations ( 109 , 110 ). In the aquatic organism, MPs can affect the GM causing several harmful effects.…”

Section: Bidirectional Interaction Between Environmental Chemicals An...mentioning

confidence: 99%

Role-Playing Between Environmental Pollutants and Human Gut Microbiota: A Complex Bidirectional Interaction

et al. 2022

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There is a growing interest in the characterization of the involvement of toxicant and pollutant exposures in the development and the progression of several diseases such as obesity, diabetes, cancer, as well as in the disruption of the immune and reproductive homeostasis. The gut microbiota is considered a pivotal player against the toxic properties of chemicals with the establishment of a dynamic bidirectional relationship, underlining the toxicological significance of this mutual interplay. In fact, several environmental chemicals have been demonstrated to affect the composition, the biodiversity of the intestinal microbiota together with the underlining modulated metabolic pathways, which may play an important role in tailoring the microbiotype of an individual. In this review, we aimed to discuss the latest updates concerning the environmental chemicals–microbiota dual interaction, toward the identification of a distinctiveness of the gut microbial community, which, in turn, may allow to adopt personalized preventive strategies to improve risk assessment for more susceptible workers.

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Perturbation of gut microbiota plays an important role in micro/nanoplastics-induced gut barrier dysfunction

Abstract: The widespread of microplastics (MPLs) and nanoplastics (NPLs), collectively abbreviated as M/NPLs, has markedly affected the ecosystem and become a global threat to human health. Multiple investigations have shown that...

Cited by 106 publications

References 68 publications

Hazard assessment of ingested polystyrene nanoplastics in Drosophila larvae

Hazard assessment of ingested polystyrene nanoplastics in Drosophila larvae

The Intestinal Barrier—Shielding the Body from Nano- and Microparticles in Our Diet

Role-Playing Between Environmental Pollutants and Human Gut Microbiota: A Complex Bidirectional Interaction

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