The widespread of microplastics (MPLs) and nanoplastics (NPLs), collectively abbreviated as M/NPLs, has markedly affected the ecosystem and become a global threat to human health. Multiple investigations have shown that...
Nanomaterials (NMs) are widely used in various areas because of their unique and useful physicochemical properties. However, they may pose toxicity risks to human health after exposure. Applicable and reliable approaches are needed for risk assessment of NMs. Herein, an intelligent analytical strategy for safety assessment of NMs is proposed that focuses on toxicity assessment using an in vitro cell model. The toxicity assessment by testing on the adverse outcome pathway in a cell culture system was defined by application of a tiered testing approach. To provide an overview of the applicable approach for risk assessment of NMs, we discuss the most commonly used techniques and analytical methods, including computational toxicology methods in dosimetry assessment, high-throughput screening for toxicity testing with high efficiency, and omics-based toxicology assessment methods. The final section focuses on the route map for an integrated approach to a testing and assessment strategy on how to extrapolate the in vitro NM toxicity testing data to in vivo risk assessment of NMs. The intelligent analytical strategy, having evolved step-by-step, could contribute to better applications for safety evaluation and risk assessment of NMs in reality.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.