Gut microbial fermentation promotes the intestinal anti-inflammatory activity of Chinese yam polysaccharides

Bai, Yajuan; Zhou, Yue; Zhang, Ruifen; Chen, Yanxia; Wang, Fengzhong; Zhang, Mingwei

doi:10.1016/j.foodchem.2022.134003

Cited by 20 publications

(7 citation statements)

References 52 publications

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“…With fermentation, NO and ROS production in LPS-induced RAW264.7 cells was significantly inhibited by seaweed polysaccharide and tea polyphenol fermented products in a concentration-dependent manner, and were more effective than those without fermentation ( p < 0.05). 52 However, the effect of tea polyphenol fermented products was similar to the control group, only the one at descending colon fermentation for 24 h was better at reducing NO production than the control group. This may be due to the use of low concentrations of tea polyphenol and the complex fermentation system.…”

Section: Food and Functionmentioning

confidence: 82%

“…Excessive intracellular ROS production and pro-inflammatory cytokines such as TNF-α and IL-6 are closely related to pathological states such as inflammation. 51,52 In this study, the effects of different seaweed polysaccharides and tea polyphenol fermented products on the production of NO, ROS, TNF-α and IL-6 in LPS-induced RAW264.7 cells were analyzed to evaluate their effects on intestinal inflammation.…”

Section: Resultsmentioning

confidence: 99%

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In vitro fermentation of seaweed polysaccharides and tea polyphenol blends by human intestinal flora and their effects on intestinal inflammation

Shen

Yang

et al. 2023

Food Funct.

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Section: Food and Functionmentioning

confidence: 82%

Section: Resultsmentioning

confidence: 99%

In vitro fermentation of seaweed polysaccharides and tea polyphenol blends by human intestinal flora and their effects on intestinal inflammation

Shen

Yang

et al. 2023

Food Funct.

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“…Chronic inflammatory diseases are recognized as the most important cause of death, with over 50% of deaths attributable to inflammation-related diseases, such as ischemic heart disease, cancer, diabetes, and NAFLD [ 72 ]. The bioactive compounds of Dioscorea , such as phenanthrene derivatives, steroidal saponins, polysaccharides and polyphenols, exert anti-inflammatory activity and have excellent effects on a wide range of inflammatory diseases [ 68 , 73 , 74 ].…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

“…In LPS-stimulated cocultured Caco-2/Raw264.7 cells, both yam polysaccharides and fecal fermented yam polysaccharides significantly inhibited the levels of inflammatory mediators nitrogen oxide (NO)/Inducible nitric oxide synthase (iNOS), tumor necrosis factor-α (TNF-α) and interleukin-1 beta (IL-1β), and increased the expression of intestinal tight junction protein 1 (ZO-1) and Occludin. Among them, the anti-inflammatory and intestinal barrier-protective effects of fecal fermented yam polysaccharides were superior to those of yam polysaccharides [ 74 ].…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Dioscorea spp.: Bioactive Compounds and Potential for the Treatment of Inflammatory and Metabolic Diseases

et al. 2023

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Dioscorea spp. belongs to the Dioscoreaceae family, known as “yams”, and contains approximately 600 species with a wide distribution. It is a major food source for millions of people in tropical and subtropical regions. Dioscorea has great medicinal and therapeutic capabilities and is a potential source of bioactive substances for the prevention and treatment of many diseases. In recent years, increasing attention has been paid to the phytochemicals of Dioscorea, such as steroidal saponins, polyphenols, allantoin, and, in particular, polysaccharides and diosgenin. These bioactive compounds possess anti-inflammatory activity and are protective against a variety of inflammatory diseases, such as enteritis, arthritis, dermatitis, acute pancreatitis, and neuroinflammation. In addition, they play an important role in the prevention and treatment of metabolic diseases, including obesity, dyslipidemia, diabetes, and non-alcoholic fatty liver disease. Their mechanisms of action are related to the modulation of a number of key signaling pathways and molecular targets. This review mainly summarizes recent studies on the bioactive compounds of Dioscorea and its treatment of inflammatory and metabolic diseases, and highlights the underlying molecular mechanisms. In conclusion, Dioscorea is a promising source of bioactive components and has the potential to develop novel natural bioactive compounds for the prevention and treatment of inflammatory and metabolic diseases.

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“…Wolfberry, yam, and chrysanthemum all have protective effects on the liver in traditional Chinese medicine. Lycium barbarum polysaccharide, yam polysaccharide, and chrysanthemum polysaccharide all have the effects of anti‐inflammatory and regulate microbial structure 14–16 . Whether wolfberry, yam, and chrysanthemum (WYC) can repair DILI and enhance the intestinal barrier effect by increasing the abundance of A. muciniphila is unclear.…”

Section: Introductionmentioning

confidence: 99%

Wolfberry, Yam, and Chrysanthemum polysaccharides increased intestinal Akkermansia muciniphila abundance and hepatic YAP1 expression to alleviate DILI

Lu,

Gong,

Gao

et al. 2023

The FASEB Journal

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Drug‐induced liver injury (DILI) is frequently induced by high dose of acetaminophen (APAP) and is concomitant with disturbances of gut flora. Akkermansia muciniphila is beneficial for the repair of liver injury. Lycium barbarum polysaccharide, yam polysaccharide, and chrysanthemum polysaccharide all have anti‐inflammatory and antioxidation effects. The objective of this study is to investigate the potential of lycium barbarum polysaccharide, yam polysaccharide, and chrysanthemum polysaccharide (LYC) in improving DILI by increasing the abundance of A. muciniphila. Initially, screening for the optimal concentrations of wolfberry, yam, and chrysanthemum (WYC) or LYC to promote A. muciniphila proliferation in vitro and validated in antibiotic (ATB)‐treated KM mice. Subsequently, APAP‐induced DILI model in BALB/c mice were constructed to examine the treatment effects of LYC. Our findings indicate that the optimal concentration ratio of WYC was 2:3:2, and LYC was 1:1:1. WYC increased A. muciniphila proliferation in vitro and in ATB‐treated mice under this ratio. Meanwhile, LYC increased A. muciniphila abundance in vitro and the combination LYC with A. muciniphila promoted the proliferation of A. muciniphila in ATB‐treated mice. The overdose of APAP resulted in the impairment of the intestinal barrier function and subsequent leakage of lipopolysaccharide (LPS). Moreover, LYC increased A. muciniphila abundance, reduced intestinal inflammation and permeability, and upregulated the expression of the tight junction protein zonula occludens protein 1 (ZO‐1) and occludin contents in the gut. Lastly, LYC inhibited LPS leakage and upregulated hepatic YAP1 expression, ultimately leading to the repair of DILI.

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Gut microbial fermentation promotes the intestinal anti-inflammatory activity of Chinese yam polysaccharides

Cited by 20 publications

References 52 publications

In vitro fermentation of seaweed polysaccharides and tea polyphenol blends by human intestinal flora and their effects on intestinal inflammation

In vitro fermentation of seaweed polysaccharides and tea polyphenol blends by human intestinal flora and their effects on intestinal inflammation

Dioscorea spp.: Bioactive Compounds and Potential for the Treatment of Inflammatory and Metabolic Diseases

Wolfberry, Yam, and Chrysanthemum polysaccharides increased intestinal Akkermansia muciniphila abundance and hepatic YAP1 expression to alleviate DILI

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