Guarana as a source of bioactive compounds

Silva, Cintia Pereira da; Soares-Freitas, Rosana Aparecida Manólio; Sampaio, Geni Rodrigues; Camargo, Adriano Costa de; Torres, Érica Miranda de

doi:10.31665/jfb.2019.6182

Cited by 12 publications

(7 citation statements)

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“…However, guarana possesses many other bioactive compounds, including PACs, that exhibit in vitro and in vivo health-promoting effects. In fact, their potential anticancer, antioxidant, antihyperglycemic and anti-obesity effects have recently been reported (da Silva et al, 2019).…”

Section: Proanthocyanidins (Pacs)mentioning

confidence: 99%

A perspective on phenolic compounds, their potential health benefits, and international regulations: The revised Brazilian normative on food supplements

Camargo¹,

Lima²

2019

JFB

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Phenolic compounds possess a myriad of health benefits, thus making them potential ingredients for the procurement of food supplements. Anvisa, Brazil’s national regulatory body, has recently revised the regulation on food supplements and only a few phenolic compounds (chlorogenic acid, rutin, proanthocyanidins, and tocopherols) have been mentioned. Despite several scientific evidences on the bioactivity of phenolics, especially concerning their antioxidant activity, Anvisa does not authorize any claims for supplements containing these compounds, except for tocopherols, which was mentioned as “vitamin E”. The upper limit doses allowed for the phenolics appear to be lower than what the literature suggests as necessary to achieve potential health benefits and might be prohibitive for supplements available in the international market. Moreover, Brazilian sources of phenolic compounds are not listed in the Normative Instruction (NI) as authorized ingredients for supplements. The Brazilian NI on food supplements has moved forward, but it is still limited.

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Section: Proanthocyanidins (Pacs)mentioning

confidence: 99%

A perspective on phenolic compounds, their potential health benefits, and international regulations: The revised Brazilian normative on food supplements

Camargo¹,

Lima²

2019

JFB

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“…The Brazilian Food Supplement Law recently recognized that guarana contains bioactive substances, hence supporting its role as a functional food ingredient [28]. Both animal and human studies have found that the consumption of guarana powder was safe and caused no toxicity in small doses (30 mg/kg for animals and 200 mg/day for humans) [29,30].…”

Section: Introductionmentioning

confidence: 99%

Insoluble-Bound Polyphenols Released from Guarana Powder: Inhibition of Alpha-Glucosidase and Proanthocyanidin Profile

Acdc

Soares

et al. 2020

Molecules

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The Brazilian Food Supplement Law recently recognized that guarana (Paullinia cupana) contains bioactive substances, hence supporting its role as a functional food ingredient. The health benefits of guarana are associated, at least in part, to its phenolic compounds. However, to the best of our knowledge, there is no literature addressing the presence of phenolic compounds in the fraction containing insoluble-bound compounds and its contribution in terms of alpha-glucosidase inhibition. The concentration of phenolic extracts released from the insoluble-bound fraction required to inhibit 50% of alpha-glucosidase (IC50) activity was 5.8-fold lower than that present in the soluble counterpart. Both fractions exhibited a mixed inhibition mode. Fourteen proanthocyanidins (dimers to tetramers) present in the insoluble-bound fraction were tentatively identified by MALDi-TOF-MS. Future studies aiming at increasing the concentration of the soluble counterpart are deemed necessary. The results presented here enhance the phenolic database of guarana and have a practical impact on the procurement of nutraceuticals and functional ingredients related to the prevention and/or management of type 2 diabetes. The Brazilian normative on food supplements has been recently revised. This study lends support to the future inclusion of guarana powder in the list of sources of proanthocyanidins for the industry of food supplements.

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“…Syringic acid that was identified in this work is also found in nuts, fruits, culinary herbs, and their processing by-products (Alvarez-Parrilla et al, 2018;Mirfat et al, 2018;Senanayake, 2018;Shahidi and Hossain, 2018). In contrast, while several feedstocks show catechin in their phenolic profile (Amarowicz and Shahidi, 2018;Silva et al, 2018;Silva et al, 2019), the presence of gallocatechin is not as common.…”

Section: Total Phenolics and Maldi-tof-ms Analysismentioning

confidence: 53%

Wood extracts as unique sources of soluble and insoluble-bound phenolics: reducing power, metal chelation and inhibition of oxidation of human LDL-cholesterol and DNA strand scission

Albishi¹,

Banoub²,

Camargo³

et al. 2019

JFB

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Palm date is an important crop in many Middle Eastern countries. In the present study, seedling date palm wood and old date palm wood were evaluated for their phenolics content. It was found that they may serve as rich source of soluble and insoluble-bound phenolics with promising reducing power and metal chelation. The observed effects were compared with those of oak, quibracho, banana, and pine woods. Syringic acid, (+)-catechin, and (+)-gallocatechin were present in five out of the six tested samples, as evaluated by MALDI-TOF-MS. Therefore, these compounds are good candidates to be monitored by the industry in order to define quality parameters. Additionally, due to their strong ability in counteracting DNA damage caused by peroxyl and hydroxyl radicals (up to 98.42%) and cupric ion-induced human low-density lipoprotein-cholesterol (LDL-c) peroxidation in vitro (up to 95.80%), wood phenolics may render antimutagenic effects and protection against cardiovascular diseases.

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Guarana as a source of bioactive compounds

Cited by 12 publications

References 0 publications

A perspective on phenolic compounds, their potential health benefits, and international regulations: The revised Brazilian normative on food supplements

A perspective on phenolic compounds, their potential health benefits, and international regulations: The revised Brazilian normative on food supplements

Insoluble-Bound Polyphenols Released from Guarana Powder: Inhibition of Alpha-Glucosidase and Proanthocyanidin Profile

Wood extracts as unique sources of soluble and insoluble-bound phenolics: reducing power, metal chelation and inhibition of oxidation of human LDL-cholesterol and DNA strand scission

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