Insoluble-Bound Polyphenols Released from Guarana Powder: Inhibition of Alpha-Glucosidase and Proanthocyanidin Profile

Acdc, Pinaffi; Gr, Sampaio; Soares, Mario J.; Shahidi, Fereidoon; Camargo, Adriano Costa de; Eafs, Torres

doi:10.3390/molecules25030679

Cited by 26 publications

(20 citation statements)

References 72 publications

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“…The structural features like many hydroxyl groups and their configuration, the ketonic functional group at C-4, and a double bond at C2–C3 on flavonoids enhanced the antioxidant ability [ 89 , 90 ]. Due to these structural features, extracts with higher phenolic compounds are already proved to have a higher antidiabetic ability via the formation of hydrogen bonds and hydrophobic interactions with enzymes and reduce their activity [ 91 , 92 ]. There are high correlations between antioxidant capacity and total phenols and total flavonoids, so the presence of a high concentration of phenolic compounds also has high antioxidant activity [ 75 ].…”

Section: Discussionmentioning

confidence: 99%

Antidiabetic, Antimicrobial, and Molecular Profiling of Selected Medicinal Plants

Aryal

Niraula

Khadayat

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Natural products have been the center of attraction ever since they were discovered. Among them, plant-based natural products were popular as analgesics, anti-inflammatory, antidiabetic, and cosmetics and possess widespread biotechnological applications. The use of plant products as cosmetics and therapeutics is deep-rooted in Nepalese society. Although there are few ethnobotanical studies conducted, extensive research of these valuable medicinal plants has not been a priority due to the limitation of technology and infrastructure. Here, we selected 4 traditionally used medicinal plants to examine their bioactive properties and their enzyme inhibition potential. α-Glucosidase and α-amylase inhibitory activities were investigated using an in vitro model followed up by antioxidant and antimicrobial activities. The present study shows that ethyl acetate fraction of Melastoma melabathrium (IC50 9.1 ± 0.3 µg/mL) and water fraction Acacia catechu (IC50 9.0 ± 0.6 µg/mL) exhibit strong α-glucosidase inhibition. Likewise, the highest α-amylase inhibition was shown by crude extracts of Ficus religiosa (IC50 29.2 ± 1.2 µg/mL) and ethyl acetate fractions of Shorea robusta (IC50 69.3 ± 1.1 µg/mL), and the highest radical scavenging activity was shown by F. religiosa with an IC50 67.4 ± 0.6 µg/mL. Furthermore, to identify the metabolites within the fractions, we employed high-resolution mass spectrometry (LC-HRMS) and annotated 17 known metabolites which justify our assumption on activity. Of 4 medicinal plants examined, ethyl acetate fraction of S. robusta, ethyl acetate fraction of M. melabathrium, and water or ethyl acetate fraction of A. catechu extracts illustrated the best activities. With our study, we set up a foundation that provides authentic evidence to the community for use of these traditional plants. The annotated metabolites in this study support earlier experimental evidence towards the inhibition of enzymes. Further study is necessary to explore the clinical efficacy of these secondary molecules, which might be alternatives for the treatment of diabetes and pathogens.

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Section: Discussionmentioning

confidence: 99%

Antidiabetic, Antimicrobial, and Molecular Profiling of Selected Medicinal Plants

Aryal

Niraula

Khadayat

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…Guarana ( Paullinia cupana ) is a plant originally found in the Amazon forest that produces fruits that are consumed for its appreciated gastronomic uses and stimulatory effect [ 44 ]. The presence of tyrosols, proanthocyanidins of different degrees of polymerization (dimes, trimers, and tetramers), and (epi)catechin were indicated as main phenolic compounds [ 44 , 45 , 46 ].…”

Section: Phenolic Compounds Found In Seedsmentioning

confidence: 99%

Natural Antioxidants from Seeds and Their Application in Meat Products

Munekata¹,

Gullón

Pateiro³

et al. 2020

Antioxidants

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The use of synthetic antioxidants in the food industry has raised important questions about the effects of prolonged consumption on human health. On top of that, the consumption of meat products has been changing due to the awareness generated by health-related organizations. In this sense, exploring strategies to develop and produce healthier meat products has become a paramount concern. Several studies explored the composition of several seeds to characterize and explore the compounds with antioxidant activity, which are mainly composed of polyphenols. The use of antioxidant extracts in meat products has shown important results to delay the oxidative reactions in meat products derived from the processing and storage of meat products. Moreover, these extracts can also replace synthetic antioxidants and preserve the quality of meat products. Therefore, the aims of this review are first, to present the sources and compounds with antioxidant activity in seeds, and second, to discuss their protective effect against oxidative reactions in meat products.

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“…In The main biologically relevant characteristic associated with phenolics is their antioxidant capacity, which can be manifested through different mechanisms, such as donation of hydrogen atoms to free radicals, interrupting oxidation chain reactions, and ability to reduce and/or chelate transition metals, which are prooxidant factors (Shahidi et al, 2019). Due to their antioxidant activity, phenolics have shown in vitro and in vivo evidence of numerous potential health-promoting effects, including anti-inflammatory activity (Colombo et al, 2019;Zhang et al, 2019), antimicrobial potential (de Camargo et al, 2017), prevention of some types of cancer (Ayoub et al, 2017), reduced risk of cardiovascular diseases (Lutz et al, 2019), prevention and management of type 2 diabetes (Pinaffi et al, 2020), and diminished risk of neurodegenerative diseases (Hanafy et al, 2020;Taslimi et al, 2019), among others.…”

Section: Bioactive Compounds Not Included In Ni 76mentioning

confidence: 99%

The gap between scientific evidence and food regulation: analyzing the updated Brazilian normative on the use of bioactives in food supplements

Danielski¹,

Silva²,

Camargo³

2020

JFB

Self Cite

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The approval of new ingredients and compounds for use in food supplements is subjected to governmental regulations in many countries. In this context, there is a gap between what the scientific literature reports and how these translate into food regulation when it comes to bioactives. In this perspective piece, we analyze the case of Anvisa’s Normative Instruction (NI) N° 76, which regulates food supplements in Brazil. This updated version of a previous Normative Instruction adds hyaluronic acid, boron, silicon, undenatured type II collagen, hydroxymethylbutyrate, methylsulfonylmethane, and palmitoylethanolamide to its list of approved compounds. According to the NI, only supplements containing undenatured type II collagen are allowed to make health claims on their labels. In addition, the list does not include any substance from major bioactive groups, such as phenolic compounds. However, this might be due to the fact that the metabolic fate of phenolics has not yet been completely clarified, which could contribute to the slowing down of their approval by Anvisa. In this case, safety issues would need to be sorted out, and a direct relationship between consumption and health effect would need to be established for allowing health claims to be made. Therefore, the need for studies on the bioefficacy of bioactive compounds is imperative.

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Insoluble-Bound Polyphenols Released from Guarana Powder: Inhibition of Alpha-Glucosidase and Proanthocyanidin Profile

Cited by 26 publications

References 72 publications

Antidiabetic, Antimicrobial, and Molecular Profiling of Selected Medicinal Plants

Antidiabetic, Antimicrobial, and Molecular Profiling of Selected Medicinal Plants

Natural Antioxidants from Seeds and Their Application in Meat Products

The gap between scientific evidence and food regulation: analyzing the updated Brazilian normative on the use of bioactives in food supplements

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