Guanidine Intoxication

Minot, A. S.

doi:10.1001/archpedi.1933.01960030051005

Cited by 19 publications

(2 citation statements)

References 26 publications

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“…10]. Methylguanidine (M G ) and guanidine (G) could be related to the uremic polyneuropathy [11] and have been experimentally shown to be epileptogenic agents [12]. y-Guanidinobutyric acid (y-GBA), M G , taurocyamine, homoarginine (HArg), creatine (CT) and creatinine (CTN ) were found to have a convulsive effect in animals when administered intracisternally [13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Serum Guanidino Compound Levels and the Influence of a Single Hemodialysis in Uremic Patients Undergoing Maintenance Hemodialysis

Deyn

Marescau

Lornoy

et al. 1987

Nephron

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Guanidino compounds are increased in uremia and are highly suspected to be uremic toxins. The serum levels of 11 guanidino compounds and the influence of a single hemodialysis were evaluated in 30 steady-state uremic patients undergoing maintenance hemodialysis. Guanidino compound levels were detected using liquid cation exchange chromatography with a highly sensitive fluorescence detection method. Highly standardized dialysis procedures were performed. Before hemodialysis, high levels were found for guanidinosuccinic acid, N-α-acetylarginine, argininic acid, creatinine, γ-guanidinobutyric acid, guanidine and methylguanidine. Guanidinosuccinic acid reached levels associated with toxic effects in vitro. After hemodialysis, although lowered, guanidinosuccinic acid, creatinine, guanidine and methylguanidine were still markedly increased. No differences in the percent decrease, during a single hemodialysis, of the studied compounds were found using different membranes such as cellulose acetate, cuprophane and polyacrylonitrile membranes. Substantial differences, however, in the percent decrease of the different guanidino compounds were found, ranging from 25 ± 13% for arginine to 74 ± 7.5% for guanidinosuccinic acid. Data reported here show that guanidino compounds are raised in serum of uremic patients undergoing maintenance hemodialysis, before as well as after a single hemodialysis, while substantial differences in the percent decrease of the different guanidino compounds are found.

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Section: Introductionmentioning

confidence: 99%

Serum Guanidino Compound Levels and the Influence of a Single Hemodialysis in Uremic Patients Undergoing Maintenance Hemodialysis

Deyn

Marescau

Lornoy

et al. 1987

Nephron

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“…1983) have been shown experimentally to be epileptogenic. Furthermore guanidine (Minot and Dodd, 1933) and rnethylguanidine levels (Giovannetti et al, 1969) are probably related t o the polyneuropathy seen in uremia. The relationship of guanidinosuccinic acid to uremic bleeding dyscrasia has also been proven (Horowitz et al, 1970).…”

mentioning

confidence: 99%

Comparative Study of Guanidino Compounds in Serum and Brain of Mouse, Rat, Rabbit, and Man

Marescau

Deyn

Wiechert

et al. 1986

Journal of Neurochemistry

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The levels of 12 guanidino compounds were determined in the serum and brain of mouse, rat, rabbit, and man using cation-exchange column chromatography with the fluorescence ninhydrin detection method. A comparative study of these compounds was made in the four groups studied, for serum and brain. In rabbit and man the different guanidino compounds were also determined in various brain regions. This study provides basic analytical data that could facilitate the interpretation of further biochemical and neurochemical studies dealing with guanidino compounds that are identified as being toxins in hyperargininemia and uremia.

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Mechanism of Experimental Uremia

Mason¹

1937

Arch Intern Med

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Guanidine Intoxication

Cited by 19 publications

References 26 publications

Serum Guanidino Compound Levels and the Influence of a Single Hemodialysis in Uremic Patients Undergoing Maintenance Hemodialysis

Serum Guanidino Compound Levels and the Influence of a Single Hemodialysis in Uremic Patients Undergoing Maintenance Hemodialysis

Comparative Study of Guanidino Compounds in Serum and Brain of Mouse, Rat, Rabbit, and Man

Mechanism of Experimental Uremia

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