Journal of Cell Biology volume 215, issue 5, P631-647 2016 DOI: 10.1083/jcb.201606081 View full text
|
|
Share
Shweta Bendre, Arnaud Rondelet, Conrad Hall, Nadine Schmidt, Yu-Chih Lin, Gary J. Brouhard, Alexander W. Bird

Abstract: The microtubule depolymerase MCAK influences chromosomal instability (CIN), but what controls its activity remains unclear. Bendre et al. show that GTSE1, a protein found overexpressed in tumors, regulates microtubule stability and chromosome alignment during mitosis by inhibiting MCAK. High levels of GTSE1 are linked to chromosome missegregation and CIN.