KIF2C exerts an oncogenic role in nonsmall cell lung cancer and is negatively regulated by miR‐325‐3p

Abstract

Nonsmall cell lung cancer (NSCLC) is one of the leading causes of cancer‐related death worldwide. Kinesin family member 2C (KIF2C), a modulator in microtubule depolymerization, bipolar spindle formation, and chromosome segregation, has been reported to take roles in cancer biology, but its role in NSCLC remains unclear. This study was intended to investigate the expression and function of KIF2C in NSCLC. Our results demonstrated that KIF2C was up‐regulated in NSCLC tissues and cell lines. The high expression of KIF2C in NSCLC tissues was significantly correlated with higher T stage (0.0078), worse differentiation status (0.0049), and lymph node metastasis (P < .0001). We also proved that the high expression level of KIF2C predicted worse prognosis of the patients. After knockdown of KIF2C, the proliferation and metastasis of NSCLC cells were inhibited. Luciferase reporter assay suggested that KIF2C was a target gene of miR‐325‐3p, which was reported to be a tumour suppressor in NSCLC. In conclusion, this study proved an oncogenic role of KIF2C in NSCLC and partly clarified the mechanism of its high expression. Our findings provided a useful insight into the mechanism of NSCLC progression and offered clues to novel therapy strategies.

Retracted: Kinesin family member 2C aggravates the progression of hepatocellular carcinoma and interacts with competing endogenous RNA

“…Recently, the oncogenic role of KIF2C has been addressed in some cancers. [11][12][13][14][15] In the present study, we demonstrated that KIF2C was highly expressed in most human cancers including HCC in the TCGA database ( Figure 1A,B). In our cohort of 220 patients, we firstly demonstrated that KIF2C expression was higher in HCC tissue than that in the adjacent nontumor tissues.…”

“…[8][9][10] Recently, increasing evidence suggested that KIF2C participated in the progression of the multiple malignancies. [11][12][13][14][15] Chen et al 16 had been drawn out the subject to briefly analyze the association between Kinesin superfamily protein expression and prognosis in HCC. However, the innate mechanism regulating cancers progression by KIF2C was not clear.…”

5 Gleason score-associated gene signatures serve as novel biomarkers for identifying early recurring events and contributing to early diagnosis for Prostate Adenocarcinoma

“…While CENPA overexpression-mediated pRb depletion is involved in the development and progression of retinoblastoma [55].TROAP has been reported to be dysregulated in various tumors such as breast cancer, liver cancer, prostate cancer, and gastric cancer, and participates in the promotion of tumor cell proliferation and distant metastasis through multiple signaling pathways such as WNT3/survivin [56][57][58][59][60]. Our study con rms that TROAP may play a major which regulates mitosis and the cell-cycle [65,66]. A reduction or loss of KIF20A expression will disrupt the normal mitotic process.…”

Upregulation of deubiquitinase PSMD14 in lung adenocarcinoma (LUAD) and its prognostic significance

“…Lung cancer has the highest morbidity and mortality rates of all cancers [1]. Non-small cell lung cancer (NSCLC) comprises approximately 85% of all lung cancers and includes adenocarcinoma, squamous-cell carcinoma, and large-cell carcinoma [2].…”