Growth, spectral and thermal studies of ibuprofen crystals

Abstract

Key words ibuprofen, gel growth, FTIR, UV-Vis, TGA/DTA. RS-Ibuprofen was crystallized for the first time in silica gel under suitable pH conditions by reduction of solubility method. The grown crystals were characterized by single crystal X-ray diffraction and density measurement. The functional groups present in the crystal were identified using Fourier transform infrared spectroscopy. Optical bandgap energy of ibuprofen was estimated as 3.19(3) eV from UV-Vis spectrum. Thermogravimetric analysis revealed that ibuprofen is thermally stable upto 102.9 °C and the initial loss of mass was due to evaporation only. Morphological study showed that the growth is prominent along b-axis and the prominent face is {100}.

Experimental and chemoinformatics evaluation of some physicochemical properties of excipients influencing release kinetics of the acidic drug ibuprofen

“…FTIR spectrum of IBU showed characteristic peaks at 2961.52 (CH 3 asymmetric stretching vibrations); 2874.38 (CH 2 asymmetric stretching vibrations); 1716.34 (C@O stretching vibrations); 1512.88 (aromatic C@C stretching vibrations); 1421.28 (CHACO deformation); 1325.82 (OH in plane deformation); 1268 (@CAH in plane deformation); 1231 (CAC stretching); 1183 (CAO stretching); 1072.23 (@CAH in plane deformation); 866 (CAH out of plane deformation); 785.85 cm À1 (CH 2 rocking vibrations). These peaks were found to be in accordance with reported standard peaks confirming the molecule as a-Methyl-4-(2-methylpropyl) benzeneacetic acid (Moffat et al, 2004;Ramukutty and Ramachandran, 2012;USPNF, 1995d).…”

Layered zinc hydroxide–ibuprofen nanohybrids: synthesis and characterization

“…Bands centred at 1460, 866, 407 and 522 cm −1 are assigned to CH 3 asymmetric deformation, C-H out of plane deformation, in plane ring deformation and CH 2 inplane rocking vibration, respectively. 34 The FTIR results confirmed the presence of IBU anions between the layers of LZH.…”

Preparation and characterization of multiactive electrospun fibers: Poly‐ɛ‐carpolactone fibers loaded with hydroxyapatite and selected NSAIDs

“…The strong band at 1420 cm −1 is due to CHCO deformation while the absorption at 668 cm −1 is attributed to the CH out of plane deformation. The peaks at 866 and 936 cm −1 may be ascribed to CH out of plane vibration and to CH 3 rocking vibration, respectively …”

“…The peaks at 866 and 936 cm 21 may be ascribed to CAH out of plane vibration and to CH 3 rocking vibration, respectively. 27 The FTIR spectrum of INDO shows also a very large number of peaks due to vibration modes of the aromatic rings. The two peaks at 1715 and 1690 cm 21 , correspond to the carboxy carbonyl stretching and benzoyl carbonyl stretching vibration modes, respectively.…”