Preparation and characterization of multiactive electrospun fibers: Poly‐ɛ‐carpolactone fibers loaded with hydroxyapatite and selected NSAIDs

Karavasili, Christina; Bouropoulos, Nikolaos; Κοντοπούλου, Ιωάννα; Smith, Ashleigh; Merwe, Susanna M. van der; Rehman, Ihtesham Ur; Ahmad, Zeeshan; Fatouros, Dimitrios G.

doi:10.1002/jbm.a.34931

Cited by 13 publications

(15 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…10a), reaching about 96% of the total drug release in the first 4 h from the PCL nanofibers. Similar results were already reported previously (Karavasili et al, 2014). The drug release rates from the fibers loaded with different amounts of ibuprofen were not significantly different, indicating that the differences in the fiber diameters and the surface morphology did not influence the release of the ibuprofen.…”

Section: Entrapment Efficacy and Dissolution Studiessupporting

confidence: 93%

Electrospun polycaprolactone nanofibers as a potential oromucosal delivery system for poorly water-soluble drugs

Potrč

Baumgartner

Roškar

et al. 2015

European Journal of Pharmaceutical Sciences

148

View full text Add to dashboard Cite

Section: Entrapment Efficacy and Dissolution Studiessupporting

confidence: 93%

Electrospun polycaprolactone nanofibers as a potential oromucosal delivery system for poorly water-soluble drugs

Potrč

Baumgartner

Roškar

et al. 2015

European Journal of Pharmaceutical Sciences

148

View full text Add to dashboard Cite

“…[16][17][18] For example, hydroxyapatite (HA) and anti-inflammatory drugs can be incorporated into polycaprolactone fibers by electrospinning, achieving sustained drug release and mineralization. 19 The CaP material with amorphous calcium phosphate (ACP) phase exists in native bone tissue, which is an intermediate phase in the HA formation process and displays good bioactivity. [20][21][22] Therefore, the electrospun ACP-containing nanofibers may have potential applications in the studies of mineralization and bone repair/tissue engineering.…”

Section: Fu Et Almentioning

confidence: 99%

Electrospinning of calcium phosphate-poly(D,L-lactic acid) nanofibers for sustained release of water-soluble drug and fast mineralization

Fu¹,

Zi²,

Xu³

et al. 2016

IJN

View full text Add to dashboard Cite

Calcium phosphate-based biomaterials have been well studied in biomedical fields due to their outstanding chemical and biological properties which are similar to the inorganic constituents in bone tissue. In this study, amorphous calcium phosphate (ACP) nanoparticles were prepared by a precipitation method, and used for preparation of ACP-poly( d , l -lactic acid) (ACP-PLA) nanofibers and water-soluble drug-containing ACP-PLA nanofibers by electrospinning. Promoting the encapsulation efficiency of water-soluble drugs in electrospun hydrophobic polymer nanofibers is a common problem due to the incompatibility between the water-soluble drug molecules and hydrophobic polymers solution. Herein, we used a native biomolecule of lecithin as a biocompatible surfactant to overcome this problem, and successfully prepared water-soluble drug-containing ACP-PLA nanofibers. The lecithin and ACP nanoparticles played important roles in stabilizing water-soluble drug in the electrospinning composite solution. The electrospun drug-containing ACP-PLA nanofibers exhibited fast mineralization in simulated body fluid. The ACP nanoparticles played the key role of seeds in the process of mineralization. Furthermore, the drug-containing ACP-PLA nanofibers exhibited sustained drug release which simultaneously occurred with the in situ mineralization in simulated body fluid. The osteoblast-like (MG63) cells with spreading filopodia were well observed on the as-prepared nanofibrous mats after culturing for 24 hours, indicating a high cytocompatibility. Due to the high biocompatibility, sustained drug release, and fast mineralization, the as-prepared composite nanofibers may have potential applications in water-soluble drug loading and release for tissue engineering.

show abstract

“…In this regard, embedding therapeutic substances into electrospun dressings followed by their subsequent release would open up new applicative biomedicine solutions to treat pains and diseases. Most promising investigations have demonstrated the incorporation and subsequent release from electrospun matrices of nonsteroidal anti‐inflammatory drugs (NSAIDs) such as ibuprofen (IBU) , ketoprofen (KET) , indomethacin , diclofenac , and meloxicam . Other electrospinning studies have been focused on the encapsulation of analgesic compounds such as paracetamol and acetylsalicylic acid (aspirin) .…”

Section: Drug Release From Electrospun Matricesmentioning

confidence: 99%

A review on electrospun polymer nanostructures as advanced bioactive platforms

2016

View full text Add to dashboard Cite

This review article deals with latest literature studies on the potential use of polymer ultrathin and nanosized structures obtained by electrospinning to design novel engineered materials with bioactive properties. The electrofluidodynamic process offers the option to form high-performance bioactive systems based on polymer yarns of nanofibers or coatings of nanobeads with high surface-to-volume ratios. The electrospun and electrosprayed nanostructures can be further functionalized by encapsulation with bioactive fillers and substances. For both scenarios, the resultant polymer nanostructures present unique bioactive properties capable of providing a beneficial impact over human's health and with improved and advanced performance for biomedicine, pharmaceutics, nutrition, bioengineering, and healthcare applications. These novel functional materials attained by the electrospinning technology can be of interest for many bioactive applications such as functional food design, food packaging, functional coatings, controlled delivery of drug solutions and, mainly, tissue engineering. This article is purposely designed to gather, for the first time, most recent and promising multi-and inter-disciplinary develop-

show abstract

Preparation and characterization of multiactive electrospun fibers: Poly‐ɛ‐carpolactone fibers loaded with hydroxyapatite and selected NSAIDs

Cited by 13 publications

References 33 publications

Electrospun polycaprolactone nanofibers as a potential oromucosal delivery system for poorly water-soluble drugs

Electrospun polycaprolactone nanofibers as a potential oromucosal delivery system for poorly water-soluble drugs

Electrospinning of calcium phosphate-poly(D,L-lactic acid) nanofibers for sustained release of water-soluble drug and fast mineralization

A review on electrospun polymer nanostructures as advanced bioactive platforms

Contact Info

Product

Resources

About