Layered zinc hydroxide–ibuprofen nanohybrids: synthesis and characterization

Abstract

The nonsteroidal anti-inflammatory drug (NSAID), ibuprofen (IBU) anion, was intercalated into the layered zinc hydroxide (LZH) to form a new organic-inorganic nanohybrid. Then, IBU-LZH nanohybrid was dispersed into chitosan for the formation of the nanocomposite. The IBU-LZH nanohybrid was characterized by powder X-ray diffraction (PXRD) to study intercalation, scanning electron microscopy (SEM) for the investigation of surface morphology, Fourier transform infrared (FTIR) spectrophotometer to study the chemical interactions and thermal gravimetric analysis/derivative thermogravimetric analysis (TGA/DTG) for understanding the thermal stability. The PXRD patterns showed that the IBU was successfully intercalated into the interlay space of LZHs as monolayers and the basal spacing of LZH increased from 9.57 to 19.54 Å. The FTIR analyses confirmed the formation of the host-guest nanohybrid. The DTG studies revealed that the thermal stability of IBU was increased after the intercalation into LZH. The in vitro release study of IBU from IBU-LZH and IBU-LZH/chitosan nanocomposite was investigated in phosphate buffer saline (PBS) solution of pH 4.8 and 7.4. The drug release from the LZH was studied by ultraviolet-visible (UV-vis) spectroscopy.

Synthesis and application of magnetic@layered double hydroxide as an anti-inflammatory drugs nanocarrier

“…time pH Particle size Refs. Zn-Al layered double hydroxide (LDH) Diclofenac sodium 80 60 h 7.4 632.6 nm [ 41 ] Sodium alginate/layered double hydroxides Diclofenac sodium 99 8 h 7.4 ND [ 42 ] Ca–Al layered double hydroxide Diclofenac sodium 84 400 min 4.6 1–3 µm [ 43 ] Zn–Al–NO 3 -layered double hydroxides Diclofenac sodium 98.4 6 h 6.8 132 ± 9 nm [ 44 ] IBU–LZH Ibuprofen 77 1200 min 4.8 50–100 nm [ 45 ] Drug-LDH loaded PCL fibers Ibuprofen 45 120 h 7.4 147 ± 37 nm [ 46 ] Alginate–zein/layered double hydroxide biocomposite Ibuprofen 97 8 h 7.4 ND [ 47 ] Magnetic@layered double hydroxide Diclofenac sodium ...…”

Preparation, characterization, antibacterial properties, and hemostatic evaluation of ibuprofen‐loaded chitosan/gelatin composite films

“…In the case of the film, a defined amount was soaked and stirred in PBS. The free amount in the supernatant for both cases was analyzed by UV spectroscopy at 265 nm …”

Controlling simonkolleite crystallisation via metallic Zn oxidation in a betaine hydrochloride solution

“…Interest in simonkolleite itself stems from several desirable properties. The layered structure has excellent potential as a cation exchange material, 17 is popular as a ller for nanocomposites, 18 has been employed as a drug carrier in systems requiring slow-release, [19][20][21] and is appealing as a catalyst or sieve. 22 Synthesis of simonkolleite has been reported, including by Li, 13 via precipitation in an ammonia solution, using ZnCl 2 as the zinc source.…”