Growth-related changes of non-histone chromatin proteins from Kirkman-Robbins hepatoma

Kiliańska, Zofia M.; Krajewska, Wanda M.; Gaczyński, M.; Marszałek, Małgorzata; Klyszejko-Stefanowicz, L

doi:10.1016/0020-711x(89)90286-3

International Journal of Biochemistry

1989

DOI: 10.1016/0020-711x(89)90286-3

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Growth-related changes of non-histone chromatin proteins from Kirkman-Robbins hepatoma

Zofia M. Kiliańska

Wanda M. Krajewska

M. Gaczyński

et al.

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Cited by 5 publications

(1 citation statement)

References 22 publications

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“…However most of the changes in NHPs were quantatively detected by biochemical methods such as column chromatography and SDSpolyacrylamide gel eletrophoresis. Unique proteins characteristic for neoplastic process have recently been observed using immunochemical detection [25,29,31,[33][34][35]521.The results of this study revealed that hepatoma-associated nonhistone protein antigens in rat hepatoma cells described recently by this laboratory [36] are also present in other rodent hepatoma, i.e., hamster Kirkman-Robbins hepatoma. Both hepatomas are transplantable and comprise poorly differentiated and very malignant tumor cells.…”

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confidence: 46%

Hepatoma‐associated nuclear matrix nonhistone antigens

Kiliańska¹,

Krajewska²,

Xie³

et al. 1991

J of Cellular Biochemistry

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Polyclonal antibodies generated against a group of high molecular weight nonhistone proteins from Morris hepatoma 7777 were used in immunological studies of hepatoma-associated nonhistone proteins in rat and hamster. We revealed the presence of cross-reactive antigens in rat Morris hepatomas 7777 and 8994, and in hamster Kirkman-Robbins hepatoma, but not in normal rat or hamster livers. These specific nonhistone proteins were found to be preferentially localized in the nuclear matrix of rat Morris hepatoma 7777 as well as hamster Kirkman-Robbins hepatoma.

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mentioning

confidence: 46%

Hepatoma‐associated nuclear matrix nonhistone antigens

Kiliańska¹,

Krajewska²,

Xie³

et al. 1991

J of Cellular Biochemistry

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Identification of a nuclear antigen with molecular weight of 48 000 differentially expressed in tumour and normal cells

Krajewska

Lipińska

Marszałek

et al. 1990

Cell Biochemistry & Function

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A non-histone protein with mol. wt of 48,000 differentially expressed in normal and tumour cells was identified using immunological criteria. Antibodies were raised against a component specific for Kirkman-Robbins hepatoma of mol. wt about 48,000 separated from hepatoma non-histone proteins by preparative electrophoresis in polyacrylamide gel. It was demonstrated by immunoblotting that Morris hepatoma 7777 and Ehrlich ascites cells share an antigenic non-histone protein with Kirman-Robbins hepatoma. Tumour cells when compared with normal cells, i.e. hamster and rat liver, are characterized by significant enrichment of this component. Intracellular distribution of the polypeptide with mol. wt 48,000 suggests that this component may be a structural protein the biosynthesis of which increases or the antigenic determinants of which change in tumour cells.

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Studies on low molecular weight nuclear protein of tumour and normal cells

Lipińska

Krajewska

Marszałek

et al. 1991

International Journal of Biochemistry

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Growth-related changes of non-histone chromatin proteins from Kirkman-Robbins hepatoma

Cited by 5 publications

References 22 publications

Hepatoma‐associated nuclear matrix nonhistone antigens

Hepatoma‐associated nuclear matrix nonhistone antigens

Identification of a nuclear antigen with molecular weight of 48 000 differentially expressed in tumour and normal cells

Studies on low molecular weight nuclear protein of tumour and normal cells

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