Growth of hippuric acid single crystals and their characterisation for NLO applications

Vijayan, N.; Babu, R. Ramesh; Gopalakrishnan, R.; Ramasamy, P.; Ichimura, M.; Palanichamy, M.

doi:10.1016/j.jcrysgro.2004.09.058

Cited by 37 publications

(15 citation statements)

References 15 publications

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“…The experimental value of density of pure hippuric acid crystal is 1.37 ± 0.02 g/cm 3 . This agrees quite well with the literature value 1.38g/cm 3 [6], confirming the identity of the crystal. Experimental values of density of (NaCl) HA and (KCl) HA crystals are 1.3465 gm/cm 3 and 1.352 g/cm 3 .…”

Section: Resultssupporting

confidence: 93%

Growth and characterization of doped hippuric acid crystals for NLO devices

Kumar

Babu

2007

Cryst. Res. Technol.

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Modified hippuric acid (HA) single crystals have been grown from aqueous solution of acetone by doping with NaCl and KCl using slow evaporation technique at constant temperature, with the vision to improve the physicochemical properties of the sample. The characterisation of grown crystals was made by X-ray powder diffraction, density and melting point measurements. TGA/DTA studies indicate that doped crystals are more stable than pure crystals. The optical transmission study and Kurtz powder SHG measurement shows the suitability of doped crystals for NLO applications. Dopant concentration is identified with ICP atomic emission spectrometer system. The Vicker`s hardness studies at room temperature, carried out on (111) crystallographic plane shows increased hardness of the doped crystals.

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Section: Resultssupporting

confidence: 93%

Growth and characterization of doped hippuric acid crystals for NLO devices

Kumar

Babu

2007

Cryst. Res. Technol.

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“…25 A band at 2938 cm −1 can be attributed to C−H stretching. 26 An intense sharp band at 1760 cm −1 and 1744 cm −1 is due to the C=O stretching of COOH. 27 The bands at 1621 cm −1 and 1608 cm −1 are due to δ b (N−H).…”

Section: Fourier Transform Infrared Spectroscopymentioning

confidence: 99%

Preparation of hippurate-zinc layered hydroxide nanohybrid and its synergistic effect with tamoxifen on HepG2 cell lines

Ali

Al‐Qubaisi²,

Hussein³

et al. 2011

IJN

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Background: A new simple preparation method for a hippurate-intercalated zinc-layered hydroxide (ZLH) nanohybrid has been established, which does not need an anion-exchange procedure to intercalate the hippurate anion into ZLH interlayers. Methods: The hippuric acid nanohybrid (HAN) was prepared by direct reaction of an aqueous suspension of zinc oxide with a solution of hippuric acid via a one-step method. Results:The basal spacing of the nanohybrid was 21.3 Å, indicating that the hippurate anion was successfully intercalated into the interlayer space of ZLH, and arranged in a monolayer fashion with the carboxylate group pointing toward the ZLH inorganic interlayers. A Fourier transform infrared study confirmed the formation of the nanohybrid, while thermogravimetry and differential thermogravimetry analyses showed that the thermal stability of the nanohybrid was markedly enhanced. The loading of hippurate in the nanohybrid was estimated to be about 38.7% (w/w), and the release of hippurate from the nanohybrid was of a controlled manner, and therefore the resulting material was suitable for use as a controlled-release formulation. HAN has synergistic properties with tamoxifen toward a HepG2 cell line, with an IC 50 value of 0.35 compared with hippurate. In the antiproliferative assay, the ratio of viable cells account for cells treated by the combination tamoxifen with HAN to untreated cells was sharply reduced from 66% to 13% after 24 and 72 hours, respectively. Conclusion: The release of hippuric acid anions from HAN occurred in a controlled manner, and the resulting material is suitable for a controlled-release formulation.

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“…In this present case, the N-H stretching frequencies are observed at 3460 and 3350 cm . The out of plane bending vibrations are normally identified in the region 1150-900 cm −1 [38,39]. The out of plane bending vibrations are set up at 900 and 870 cm −1 .…”

Section: Amino Group Vibrationsmentioning

confidence: 99%