Growth Hormone in Protein-Losing Enteropathy

Pimstone, B. L.; Bank, S; Buchanan-Lee, B.

doi:10.1016/s0140-6736(68)91732-7

Cited by 8 publications

(2 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Fasting [26], anorexia nervosa [14], renal failure [32], and proteinlosing enteropathy [23] are all associated with elevated levels of circulating GH. Of more direct relevance to infantile malnutrition may be the fact that babies born small for their gestational age, who are thought to have been malnourished in utero, have high levels of GH [11], while babies born to diabetic mothers, who may have been overnourished in utero, have low levels of GH at birth [30].…”

Section: Discussionmentioning

confidence: 99%

Metabolic and Hormonal Responses to Glucose and Glucagon in Patients with Infantile Malnutrition

Milner¹

1971

Pediatr Res

View full text Add to dashboard Cite

ExtractThe interrelations of plasma levels of glucose, free fatty acids (FFA), a-amino nitrogen (a-aaN), insulin, and growth hormone (GH) were studied in 26 malnourished infants shortly after admission to the hospital and again several weeks later when they had recovered. In the sick children (SC) fasting levels of FFA and GH were high, and insulin and a-aaN were low; with recovery FFA, a-aaN and insulin levels became normal, and GH levels fell. No change occurred in glucose levels.Ten infants were given glucose (0.5 g/kg body weight) intravenously on the 1st or 2nd day after admission and again 6-12 weeks later. Glucose tolerance was impaired in the sick group and, although improved, was not normal when the children had recovered from the nutritional insult. Insulin secretion was stimulated by glucose in those that had recovered (RC), but not in the SC. No significant change occurred in either FFA or a-aaN levels in these groups.Nine infants received glucagon (0.1 mg/kg body weight) intravenously on the 2nd to 6th day after admission and again 6-12 weeks later. Glucagon caused a rise in glucose levels that were greater in RC than in SC but did not cause a significant change in insulin levels in either group. Free fatty acid levels were higher in SC throughout the test, but in both groups FFA levels responded similarly to glucagon administration, falling 10 and 60 min after the injection.Changes in GH levels in plasma after glucose or glucagon administration were compared with the changes caused by five venepunctures in RC. Venepunctures and glucose caused similar rises in GH levels, but glucagon caused a greater rise than either. It was concluded that the stress of repeated venepunctures caused a rise in GH levels in plasma in all three tests, but that, independent of this, glucagon stimulated GH secretion. SpeculationInsulin secretion is impaired in infantile malnutrition and does not improve at the same rate as clinical recovery occurs, suggesting that normal /? cell function is not essential for rapid growth. The role of growth hormone in malnutrition is not clear, but it appears to be involved more in the metabolic adaptation to malnutrition than in the control of growth.

show abstract

Section: Discussionmentioning

confidence: 99%

Metabolic and Hormonal Responses to Glucose and Glucagon in Patients with Infantile Malnutrition

Milner¹

1971

Pediatr Res

View full text Add to dashboard Cite

show abstract

“…Umgehung der enteralen Glucoseresorption und der damit verbundenen Aktivierung stoffwechselregulierender Faktoren des Gastrointestinaltraktes wie Sekretin, Pankreozymin, Gastrin und Glucagon (33,46,51,62). Dadurch wird zwar die erheblich stärkere Stimulierung der Insulinsekretion durch das Pankreas ausgeschaltet, wesentlich besser werden jedoch die Änderungen im Regelkreis des peripheren Insulinspiegels zugänglich; eindeutigere Beurteilung der Glucose-Assimilation durch den exponentiellen Teil des Konzentrationsabfalls;…”

unclassified

Zum intravenösen Glucosetoleranztest

Kruse-Jarres¹,

C²,

Grohmann³

et al. 1971

Dtsch med Wochenschr

View full text Add to dashboard Cite

Verglichen mit der einfachen Handhabung des oralen Glucosetoleranztests ist der intravenöse Glucosetoleranztest zwar aufwendiger, zugleich aber aussagekräftiger, wenn es darum geht, latente oder beginnende diabetische Stoffwechselstörungen aufzudecken. Dabei verdient die kontinuierliche Aufzeichnung der Blutglucose den Vorzug vor Stichprobenuntersuchungen, weil sie einerseits Beginn und Ende des exponentiellen Abbaus besser zu beurteilen, anderseits den Regressionswinkel genauer zu bestimmen erlaubt. Am günstigsten erwies sich far diesen Zweck eine Dosis von 0,33 g/kg Körpergewicht, die innerhalb von zwei Minuten intravenös injiziert werden sollte, nachdem der Proband zuvor mindestens 24 Stunden keinen Alkohol, mindestens 12 Stunden keine Nahrung zu sich genommen hatte und die letzte Mahlzeit möglichst kohlenhydratarm war. Aus der Blutzuckerkonzentration, die in bestimmten Abständen gemessen wirderstmals vier Minuten nach Injektionsbeginn, dann von der 10. bis zur 60. Minute alle zehn Minuten sich die Assimilationskonstante kG berechnen. Bei kG-Werten iiber 2,5 besteht Verdacht auf Insulin-überproduktion, der Normalbereich liegt zwischen 1,0 und 2,5, kG-Werte zwischen 0,7 und 1,0 zeigen Stoffwechselstörungen mit herabgesetzter Glucosetoleranz ohne manifeste Zeichen eines Diabetes an, und kG-Werte unter 0,7 kennzeichnen den manifesten Diabetes mellitus. 34, 53, 59). Da oft erhebliche Meinungsverschiedenheiten über die Beurteilung des intravenösen Glucosetoleranztests be-142,4 Kruse-Jarres u. a.: Zum intravenösen Glucosetoleranztest Deutsche Medizinische Wochenschrift

show abstract

The physical development of children with cystic fibrosis

Kreissl

Mörchen

et al. 1972

Z. Kinder-Heilk.

View full text Add to dashboard Cite

Growth Hormone in Protein-Losing Enteropathy

Cited by 8 publications

References 10 publications

Metabolic and Hormonal Responses to Glucose and Glucagon in Patients with Infantile Malnutrition

Metabolic and Hormonal Responses to Glucose and Glucagon in Patients with Infantile Malnutrition

Zum intravenösen Glucosetoleranztest

The physical development of children with cystic fibrosis

Contact Info

Product

Resources

About