Growth hormone deficiency and coeliac disease: an unusual association?

Bozzola, Mauro; Giovenale, Diletta; Bozzola, Elena; Meazza, Cristina; Martinetti, Miryam; Tinelli, Carmine; Corazza, Gino Roberto

doi:10.1111/j.1365-2265.2005.02227.x

Cited by 38 publications

(39 citation statements)

References 19 publications

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“…18 We recently described three short children with CD and GHD, who increased their growth rate only after gluten-free diet associated with growth hormone therapy, suggesting a possible association between these two diseases. 16 In the study presented here, in unselected cases admitted for short stature, the prevalence of CD varies from 0.31% to 3.77%, with a mean value of 0.63%, which is very similar to the prevalence described in Italian children. 3 Some authors 12,19,20 have reported higher prevalence of CD in short children.…”

Section: Discussionsupporting

confidence: 67%

“…15 Among our endocrinological patients with growth failure, we recently found three cases of CD associated with growth hormone deficiency (GHD). 16 The aim of this study was to further evaluate the relationship between GHD and CD, investigating the prevalence of CD and GHD in children screened for short stature in eight pediatric endocrinological centers of different Italian regions.…”

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confidence: 99%

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The Prevalence of Growth Hormone Deficiency and Celiac Disease in Short Children

Giovenale¹,

Meazza²,

Cardinale³

et al. 2006

Clinical Medicine & Research

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Section: Discussionsupporting

confidence: 67%

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confidence: 99%

The Prevalence of Growth Hormone Deficiency and Celiac Disease in Short Children

Giovenale¹,

Meazza²,

Cardinale³

et al. 2006

Clinical Medicine & Research

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“…6 CD causes basically three clinical conditions such as classical, atypical and asymptomatic forms. Nonetheless, it causes growth retardation, 7 autoimmune diseases 8 and malignancies. 9 Preventing these consequences depends on early diagnosis and treatment of the disease.…”

Section: Introductionmentioning

confidence: 99%

Investigation of celiac disease according to Marsh classification in childhood

Bekdaş

Ünal²,

Demircioğlu

2017

Bangladesh J Med Sci

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Background: Celiac disease (CD) is an autoimmune disorder of the small intestine related to gluten. CD is diagnosed by the evaluation of histologic findings according to the Marsh classification. Objectives: To evaluate the clinical and laboratory differences of CD according to Marsh classification. Patients and method: The records of ≥Marsh 2 histologically diagnosed 132 cases were evaluated. Results: It was determined that 7(5.3%) cases were Marsh 2, 32(24.2%) were Marsh 3a, 73(55.3%) were Marsh 3b, and 20(15.1%) were Marsh 3c. Vomiting in Marsh 2 was significantly lower than Marsh 3b and Marsh 3c (respectively, 14.3% vs. 56.9%, p=0.029; and 14.3% vs. 75%, p=0.005). Hemoglobin was significantly higher in Marsh 2 than Marsh 3b and Marsh 3c (respectively, 11.9±1.7 vs. 10.5±1.6 g/dl, p=0.038 and; 11.9±1.7 vs. 9.8±1.6 g/dl, p=0.005). Positive detection ratio for tTG IgA was significantly lower in Marsh 2 than Marsh 3a, Marsh 3b and Marsh 3c (respectively, 66.7% vs. 100%, p<0.001; 66.7% vs. 100%, p<0.001; and 66.7% vs. 94.1%, p=0.003). After the onset of gluten free diet, the time passed for the disappearance of tTG IgA seropositivity is significantly shorter in Marsh 2 than Marsh 3c (6±3.6 vs. 9.7±2.5 months, p=0.017). Conclusions: Gastrointestinal symptoms are more frequent in patients with severe small intestinal mucosal injury. tTG IgA seropositivity is associated with more severe disease. Clinical and laboratory findings of the patients are exacerbated when histopathological findings improve in CD.

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“…Hypocellularity has been observed in the hypothalamic areas involved in this control in DS subjects [40]. Decreased secretion of GH may also be caused by several non-pituitary disorders, such as hypothyroidism [42,43], coeliac disease [44] and obesity [45,46].…”

Section: Hormone and Insulin-like Growth Factor Imentioning

confidence: 99%

Current Knowledge on Growth Hormone and Insulin-Like Growth Factors and their Role in the Central Nervous System: Growth Hormone in Down Syndrome

Myrelid¹

2012

TOEJ

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Down syndrome (DS) is a chromosomal disorder associated with short stature and psychomotor delay. Growth hormone (GH) and insulin-like growth factor I (IGF-I) are of interest in DS as the pronounced growth retardation coincides in time when GH becomes essential for growth. Simultaneously mean intelligence quotient (IQ) decreases markedly.There is no evidence of a general GH deficiency in children with DS, but suboptimal endogenous production of GH and selective deficiency of IGF-I have been demonstrated. GH and IGF-I are important brain growth promoting factors. IGF receptors are present in brain cells from foetuses with DS, but there is no information as to whether disturbances of intracerebral GH binding or IGF-I production may contribute to the brain dysfunction in DS.GH therapy normalized growth velocity and improved fine motor performance in young children with DS, but the limited therapy was followed by a marked "catch-down" growth and lacked effect on final height. In adolescents with DS treatment with GH during early childhood show some positive late effects, where subjects previously treated had greater head circumference and improved performance regarding cognitive function and motor skills.Few studies have addressed the effect of GH in Down syndrome. Nevertheless, GH has been designated beneficial effects on cognition, energy, mood and behaviour through extensive studies in several other conditions and it is not unlikely that GH may have similar effects in DS. It should be emphasised that even small changes in psychomotor attainment may be of substantial importance in a developmentally delayed population.

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Growth hormone deficiency and coeliac disease: an unusual association?

Abstract: GH secretion should be evaluated in coeliac patients showing no catch-up growth after a period on a gluten-free diet in spite of reversion to seronegativity for EMA. In the case of GHD and CD, replacement GH therapy should be started during a gluten-free diet.

Cited by 38 publications

References 19 publications

The Prevalence of Growth Hormone Deficiency and Celiac Disease in Short Children

The Prevalence of Growth Hormone Deficiency and Celiac Disease in Short Children

Investigation of celiac disease according to Marsh classification in childhood

Current Knowledge on Growth Hormone and Insulin-Like Growth Factors and their Role in the Central Nervous System: Growth Hormone in Down Syndrome

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