Growth, Heart Weight, Cardiac Lipid, and Pathology of Chickens Fed Soybean Oil or Oil Extracted from Different Rapeseed Cultivars

Hulan, H. W.; Corner, A. H.; Nash, D. M.; Proudfoot, F. G.

doi:10.3382/ps.0611154

Cited by 9 publications

(1 citation statement)

References 31 publications

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“…At 112 days, spermatids were found in a small number of birds in each treatment group. From this study, the CONTAM Panel identified a NOAEL of about 0.16 g/kg bw per day for heart lesions and a LOAEL of 0.02 g/kg bw per day for liver toxicity (increase incidence of sinusoidal distension) (Hulan et al., ; Corner et al., ).…”

Section: Assessmentmentioning

confidence: 99%

Erucic acid in feed and food

Knutsen¹,

Alexander²,

Barregård³

et al. 2016

EFS2

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Erucic acid is the trivial name of the fatty acid cis-13-docosenoic acid and occurs at high concentrations mainly in the seeds of species of the Brassicaceae (e.g. rape seed or mustard seed). The European Commission requested EFSA to deliver a scientific opinion on the risks for animal and human health related to the presence of erucic acid in feed and food. For most humans, the main contributor to dietary exposure to erucic acid was the food group 'Fine bakery wares'. In 'Infants', 'Food for infants and small children' was the main contributor to exposure. The heart is the principal target organ for toxic effects after exposure. Myocardial lipidosis was identified as the critical effect for chronic exposure to erucic acid. This effect is reversible and transient during prolonged exposure. A tolerable daily intake (TDI) of 7 mg/kg body weight (bw) per day for erucic acid was established, based on a no observed adverse effect level of 0.7 g/kg bw per day for lipidosis in young rats and newborn piglets. Mean chronic exposure of the different groups of the population did not exceed the TDI. The two highest 95th percentile dietary exposure levels were observed for infants (ranging from 1.7 to 7.4 mg/kg bw per day, minimum lower bound (LB) -maximum upper bound (UB)) and other children (ranging from 2.1 to 9.5 mg/kg bw per day, minimum LB -maximum UB), the last max UB estimate being above the TDI. This may indicate a risk for young individuals with high erucic acid exposure. In pigs, levels of erucic acid are unlikely to represent a health concern. However, for poultry, the small margin between the lowest observed adverse effect level (LOAEL) and the estimated exposure may indicate a health risk where maximum inclusion rates are applied. Due to the absence of adequate data, the risk for ruminants, horses, fish and rabbits could not be assessed.

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Section: Assessmentmentioning

confidence: 99%