1987
DOI: 10.1002/bit.260290110
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Growth dynamics of a methylotroph (Methylomonas L3) in continuous cultures. II. Growth inhibition and comparison against an unstructured model

Abstract: High methanol concentrations have a negative effect on the growth rate and the biomass yield of growth transients induced by methanol pulses in continuous cultures of Methylomonas L3. The physiological basis of this effect is investigated by measuring the effect of the methanol pulse on the cell energy charge (EC) and ATP, ADP, and AMP concentrations, and by comparing the results of the pulse transients against an unstructured model. The methanol pulse is shown to lead to increased values of the cell EC and AT… Show more

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Cited by 10 publications
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“…However, while high activities for the enzymes of the H 4 MPT pathway have been measured, mutants in these enzymes revealed only very subtle phenotypes, suggesting a minor role in formaldehyde oxidation. Formate dehydrogenase activity was reported only in cells of M. flagellatus (and other RuMP methylotrophs) when grown in a chemostat at low dilution rates (6,12,13), consistent with the nonessential role of the linear pathway. However, here we detected all the components of the linear pathway, including the two alternative formate dehydrogenases.…”
Section: Resultsmentioning
confidence: 73%
“…However, while high activities for the enzymes of the H 4 MPT pathway have been measured, mutants in these enzymes revealed only very subtle phenotypes, suggesting a minor role in formaldehyde oxidation. Formate dehydrogenase activity was reported only in cells of M. flagellatus (and other RuMP methylotrophs) when grown in a chemostat at low dilution rates (6,12,13), consistent with the nonessential role of the linear pathway. However, here we detected all the components of the linear pathway, including the two alternative formate dehydrogenases.…”
Section: Resultsmentioning
confidence: 73%