Growing vertical aligned mesoporous silica thin film on nanoporous substrate for enhanced degradation, drug delivery and bioactivity

Li, Zhe; He, Yide; Klausen, Lasse Hyldgaard; Ning, Yan; Liu, Jing; Chen, Fanghao; Song, Wen; Dong, Mingdong; Zhang, Yumei

doi:10.1016/j.bioactmat.2020.10.026

Cited by 26 publications

(22 citation statements)

References 69 publications

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“…As a representative example, Li et al. [ 288 ] grew vertical aligned mesoporous silica thin film alongside the walls of the titania nanotubes array. DEX can be effectively loaded into the hierarchical two‐layered nanotubular structure, and its release enhanced early adhesion of osteoblast.…”

Section: Clinical Challenges Of Implants With Charge‐transfer Monitoring or Regulating Abilitiesmentioning

confidence: 99%

“…In order to prolong the drug release term, researchers have screened various drug loading materials, most of which are organic materials such as liposomes, [283] alginate hydrogel, [284] nitrocellulose, [282] poly(ethyl-vinyl) acetate, [285] and poly (lactic-co-glycolic acid). [286] Inorganic drug loading layer, including titania, [287] silica, [288] and hydroxyapatite, [289] is currently a new research focus, due to their higher biocompatibility. As a representative example, Li et al [288] grew vertical aligned mesoporous silica thin film alongside the walls of the titania nanotubes array.…”

Section: Chemical Modificationmentioning

confidence: 99%

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Biomedical Implants with Charge‐Transfer Monitoring and Regulating Abilities

et al. 2021

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Transmembrane charge (ion/electron) transfer is essential for maintaining cellular homeostasis and is involved in many biological processes, from protein synthesis to embryonic development in organisms. Designing implant devices that can detect or regulate cellular transmembrane charge transfer is expected to sense and modulate the behaviors of host cells and tissues. Thus, charge transfer can be regarded as a bridge connecting living systems and human‐made implantable devices. This review describes the mode and mechanism of charge transfer between organisms and nonliving materials, and summarizes the strategies to endow implants with charge‐transfer regulating or monitoring abilities. Furthermore, three major charge‐transfer controlling systems, including wired, self‐activated, and stimuli‐responsive biomedical implants, as well as the design principles and pivotal materials are systematically elaborated. The clinical challenges and the prospects for future development of these implant devices are also discussed.

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Section: Clinical Challenges Of Implants With Charge‐transfer Monitoring or Regulating Abilitiesmentioning

confidence: 99%

Section: Chemical Modificationmentioning

confidence: 99%

Biomedical Implants with Charge‐Transfer Monitoring and Regulating Abilities

et al. 2021

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“…Moreover, it has a high surface area as one of solid-state nanofilms [ 21 , 22 ]. The open and uniform nanochannel array displays high molecular permeability in addition to outstanding selectivity towards the size and charge of molecules [ 23 , 24 , 25 , 26 , 27 , 28 ]. On the one hand, VMSF with ultrasmall nanochannels can keep away larger molecules that could passivate the underlying electrode surface, allowing direct detection of complex samples without sample pre-treatment.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Sensor Nanoarchitectonics for Sensitive Detection of Uric Acid in Human Whole Blood Based on Screen-Printed Carbon Electrode Equipped with Vertically-Ordered Mesoporous Silica-Nanochannel Film

Yang

Liu

et al. 2022

Nanomaterials

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Screen-printed carbon electrodes (SPCEs) bear great potential in the detection of biomarker in clinical samples with low sample consumption. However, modification of electrode surfaces to improve the anti-interference ability and sensitivity is highly desirable for direct electroanalysis of whole blood samples. Here, a reliable and miniaturized electrochemical sensor is demonstrated based on SPCE equipped with vertically-ordered mesoporous silica-nanochannel film (VMSF). To achieve stable binding of VMSF and improve the electrocatalytic performance, electrochemically reduced graphene oxide (ErGO) is applied as a conductive adhesion layer, that is in situ reduced from GO nanosheets during fast growth (less than 10 s) of amino groups modified VMSF (NH2-VMSF) using electrochemically assisted self-assembly (EASA). In comparison with bare SPCE, NH2-VMSF/ErGO/SPCE exhibits decreased oxidation potential of uric acid (UA) by 147 mV owing to significant electrocatalytic ability of ErGO. The dual signal amplification based on electrocatalysis of ErGO and enrichment of nanochannels leads to enhanced peak current by 3.9 times. Thus, the developed NH2-VMSF/ErGO/SPCE sensor enables sensitive detection of UA in the range from 0.5 μM to 180 μM with a low limit of detection (LOD, 129 nM, S/N = 3). Owing to good anti-fouling ability and high selectivity of the sensor, direct and rapid detection of UA in human whole blood is realized with very low sample consumption (50 μL).

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“…Among the developed SSN, vertically ordered mesoporous silica nanochannel film (VMSF) exhibits high chemical and thermal stability, ordered and vertically aligned nanochannels (nanopores), uniform pore size distribution, high pore density, and ease of modification ( Nasir et al, 2018 ; Jiokeng et al, 2019 ; Ullah et al, 2021 ; Walcarius, 2021 ). The ultrasmall (usually 2–3 nm) and high-density (up to 4∼8 × 10 12 /cm 2 ) nanochannel arrays make it possible to significantly improve the sensor performance as electrode modification materials ( Mi et al, 2020 ; Li et al, 2021a ; Asadpour et al, 2021 ; Li et al, 2021b ; Xiao et al, 2021 ). On the one hand, a large number of silanol groups (Si-OH) with low pKa (∼2) endow the VMSF with a negatively charged surface, which can accelerate the transfer of positively charged molecules to the electrode surface, leading to a significant enrichment effect.…”

Section: Introductionmentioning

confidence: 99%

A Flexible Electrochemiluminescence Sensor Equipped With Vertically Ordered Mesoporous Silica Nanochannel Film for Sensitive Detection of Clindamycin

Wei

et al. 2022

Front. Chem.

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Fast, convenient, and highly sensitive detection of antibiotic is essential to avoid its overuse and the possible harm. Owing to enrichment effect and antifouling ability of ultrasmall nanochannels, the vertically ordered mesoporous silica nanochannel film (VMSF) has great potential in the development of the facile electrochemiluminescence (ECL) sensor for direct and sensitive analysis of antibiotics in complex samples. In this study, we demonstrated a flexible ECL sensor based on a cost-effective electrode covered with a VMSF for sensitive detection of clindamycin. Polyethylene terephthalate coated with indium tin oxide (PET-ITO) is applied as a flexible electrode to grow VMSF using the electrochemically assisted self-assembly (EASA) method. The negatively charged VMSF nanochannels exhibit significant enrichment toward the commonly used cationic ECL luminophores, tris(2,2-bipyridyl) dichlororuthenium (II) (Ru (bpy)32+). Using the enhanced ECL of Ru (bpy)32+ by clindamycin, the developed VMSF/PET-ITO sensor can sensitively detect clindamycin. The responses were linear in the concentration range of 10 nM–25 μM and in the concentration range of 25–70 μM. Owing to the nanoscale thickness of the VMSF and the high coupling stability with the electrode substrate, the developed flexible VMSF/PET-ITO sensor exhibits high signal stability during the continuous bending process. Considering high antifouling characteristic of the VMSF, direct analysis of clindamycin in a real biological sample, human serum, is realized.

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Growing vertical aligned mesoporous silica thin film on nanoporous substrate for enhanced degradation, drug delivery and bioactivity

Cited by 26 publications

References 69 publications

Biomedical Implants with Charge‐Transfer Monitoring and Regulating Abilities

Biomedical Implants with Charge‐Transfer Monitoring and Regulating Abilities

Electrochemical Sensor Nanoarchitectonics for Sensitive Detection of Uric Acid in Human Whole Blood Based on Screen-Printed Carbon Electrode Equipped with Vertically-Ordered Mesoporous Silica-Nanochannel Film

A Flexible Electrochemiluminescence Sensor Equipped With Vertically Ordered Mesoporous Silica Nanochannel Film for Sensitive Detection of Clindamycin

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