Group IV nanodots: synthesis, surface engineering and application in bioimaging and biotherapy

Xu, Yaxin; Li, Peipei; Cheng, Dan; Wu, Cuiyan; Lu, Qiujun; Yang, Weipeng; Zhu, Xiaohua; Yin, Peng; Liu, Meiling; Li, Haitao; Zhang, Youyu

doi:10.1039/d0tb01881c

Cited by 61 publications

(30 citation statements)

References 176 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Physical methods involve arc discharge, plasma treatment and laser ablation [10]. As shown in Figure 2 and Table 1, the methods of preparing CNDs can be classified broadly into top-down or bottom-up syntheses [11][12][13][14][15][16][17][18][19]. Top-down methods generally involve a larger carbon source being fragmented into increasingly smaller particles by using hydrothermal or solvothermal cutting, laser ablation, chemical oxidation releasing or etching, and intercalation.…”

Section: Synthesismentioning

confidence: 99%

Recent Advances in Carbon Nanodots: A Promising Nanomaterial for Biomedical Applications

Khan

Dunphy

Anike

et al. 2021

IJMS

View full text Add to dashboard Cite

Carbon nanodots (CNDs) are an emerging class of nanomaterials and have generated much interest in the field of biomedicine by way of unique properties, such as superior biocompatibility, stability, excellent photoluminescence, simple green synthesis, and easy surface modification. CNDs have been featured in a host of applications, including bioimaging, biosensing, and therapy. In this review, we summarize the latest research progress of CNDs and discuss key advances in our comprehension of CNDs and their potential as biomedical tools. We highlighted the recent developments in the understanding of the functional tailoring of CNDs by modifying dopants and surface molecules, which have yielded a deeper understanding of their antioxidant behavior and mechanisms of action. The increasing amount of in vitro research regarding CNDs has also spawned interest in in vivo practices. Chief among them, we discuss the emergence of research analyzing CNDs as useful therapeutic agents in various disease states. Each subject is debated with reflection on future studies that may further our grasp of CNDs.

show abstract

Section: Synthesismentioning

confidence: 99%

Recent Advances in Carbon Nanodots: A Promising Nanomaterial for Biomedical Applications

Khan

Dunphy

Anike

et al. 2021

IJMS

View full text Add to dashboard Cite

show abstract

“…The surface of nanodots must be modified for compatibility with biological systems in order to facilitate their in vitro and in vivo applications. Surface functionalization improves stability and water-solubility, of nanodots, which can be further conjugated with biomolecules of interest for biomedical applications ( Valcourt et al, 2018 ; Xu et al, 2020 ). Different techniques involving coupling are in use for a long time.…”

Section: Bioconjugation Strategies For Nanotechnology-based Agentsmentioning

confidence: 99%

Carbon Based Nanodots in Early Diagnosis of Cancer

et al. 2021

View full text Add to dashboard Cite

Detection of cancer at an early stage is one of the principal factors associated with successful treatment outcome. However, current diagnostic methods are not capable of making sensitive and robust cancer diagnosis. Nanotechnology based products exhibit unique physical, optical and electrical properties that can be useful in diagnosis. These nanotech-enabled diagnostic representatives have proved to be generally more capable and consistent; as they selectively accumulated in the tumor site due to their miniscule size. This article rotates around the conventional imaging techniques, the use of carbon based nanodots viz Carbon Quantum Dots (CQDs), Graphene Quantum Dots (GQDs), Nanodiamonds, Fullerene, and Carbon Nanotubes that have been synthesized in recent years, along with the discovery of a wide range of biomarkers to identify cancer at early stage. Early detection of cancer using nanoconstructs is anticipated to be a distinct reality in the coming years.

show abstract

“…Carbon nanodots (CND) have shown great potential in cancer diagnosis and treatment based on readily available materials, facile synthesis techniques, highly tunable fluorescence properties, and natural biocompatibility [1,2]. With versatile surface functionalization, the promising active targeting CND have been engineered by ligand modification binding to overexpressed receptors in tumor, enhancing the targeted accumulation of CND in tumorous tissues, and decreasing the toxicity in surrounding normal tissues [3,4]. However, functionalization methods inevitably partially destroy the material structure of CND, which might cause the loss of certain intrinsic properties such as compromised fluorescence intensity.…”

Section: Introductionmentioning

confidence: 99%

Tumor-Targeted Fluorescence Imaging and Mechanisms of Tumor Cell-Derived Carbon Nanodots

Huo

Liang

et al. 2022

Pharmaceutics

View full text Add to dashboard Cite

An ideal cancer diagnostic probe should possess precise tumor-targeted accumulation with negligible sojourn in normal tissues. Herein, tumor cell-derived carbon nanodots (C-CNDU87 and C-CNDHepG2) about 3~7 nm were prepared by a solvothermal method with stable fluorescence and negligible cytotoxicity. More interestingly, due to the differences in gene expression of cancers, C-CND structurally mimicked the corresponding precursors during carbonization in which carbon nanodots were functionalized with α-amino and carboxyl groups with different densities on their edges. With inherent homology and homing effect, C-CND were highly enriched in precursor tumor tissues. Mechanistic studies showed that under the mediation of the original configuration of α-amino and carboxyl groups, C-CND specifically bound to the large neutral amino acid transporter 1 (LAT1, overexpressed in cancer cells), achieving specific tumor fluorescence imaging. This work provided a new vision about tumor cell architecture-mimicked carbon nanodots for tumor-targeted fluorescence imaging.

show abstract

Group IV nanodots: synthesis, surface engineering and application in bioimaging and biotherapy

Abstract: Group IV nanodots (NDs) including carbon (C), silicon (Si) and germanium (Ge) NDs have been aroused much attention as one types of important nanomaterials that widely studied in optoelectronic, semiconductors,...

Cited by 61 publications

References 176 publications

Recent Advances in Carbon Nanodots: A Promising Nanomaterial for Biomedical Applications

Recent Advances in Carbon Nanodots: A Promising Nanomaterial for Biomedical Applications

Carbon Based Nanodots in Early Diagnosis of Cancer

Tumor-Targeted Fluorescence Imaging and Mechanisms of Tumor Cell-Derived Carbon Nanodots

Contact Info

Product

Resources

About