Group II phospholipase A2 in serum after knee surgery and intramedullary nailing of tibial shaft fracture

Lindström, Timo; Gullichsen, Eero; Heinonen, Olli J.; Grönroos, Juha; Nevalainen, Timo J.; Niinikoski, J

doi:10.1016/s0020-1383(96)00192-1

Cited by 9 publications

(4 citation statements)

References 14 publications

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“…Indicators of C-reactive protein (CRP), interleukin-10 (IL-10), phospholipase A2 (PLA2) and fibrinogen β polypeptide chain gene (Fbg) are critical inflammatory factors or important enzymes of inflammatory response. Investigations on how these indicators are used for predicting progression of lower extremity trauma have been previously conducted (7–9). …”

Section: Introductionmentioning

confidence: 99%

The association between the levels of CRP, IL-10, PLA2, Fbg and prognosis in traumatic fracture of lower limb

Jiao

Wang

Xiao

et al. 2016

Experimental and Therapeutic Medicine

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The aim of the present study was to examine changes of sera levels of C-reactive protein (CRP), interleukin-10 (IL-10), phospholipase A2 (PLA2) and fibrinogen β polypeptide chain gene (Fbg) in patients with traumatic fracture of lower limb, and to evaluate their association with prognosis. The changes in sera levels of CRP, IL-10, PLA2 and Fbg were observed at the time of injury, 24 h, and 5 and 7 days after surgery in 90 patients with traumatic fracture of lower limb. In addition, 50 cases, who presented for health examination, were included as the normal controls. The expression of sera levels of CRP, IL-10, PLA2 and Fbg in patients with traumatic fracture of lower limb, was markedly higher than that in the normal controls prior to surgery (P<0.05). The concentration of CRP significantly increased within 24 h after emergency, but decreased gradually as the wound healed, compared to the controls. Pre- and postoperative IL-10 levels increased within 24 h and then decreased gradually. The level of PLA2 in patients before and after surgery was increased, and then decreased gradually. The level of Fbg in patients with trauma was increased after 24 h and then decreased, and increased gradually. The correlation of serum CRP and IL-10 levels (r=0.634, P<0.05), and that of PLA2 and IL-10 levels (r=0.617, P<0.05) were positive. In conclusion, the expression of CRP, IL-10, PLA2 and Fbg levels in traumatic fracture of lower limb markedly increased and was closely associated with prognosis. CRP, IL-10, PLA2 and Fbg levels may therefore serve as useful indexes in determining the progression and prognosis of patients with traumatic fracture of lower limb.

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Section: Introductionmentioning

confidence: 99%

The association between the levels of CRP, IL-10, PLA2, Fbg and prognosis in traumatic fracture of lower limb

Jiao

Wang

Xiao

et al. 2016

Experimental and Therapeutic Medicine

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“…CRP levels of about 10-16 mg/dL can be seen after total hip or knee arthroplasty (Aalto et al 1984, Niskanen et al 1996, Okafor and Maclellan 1998, White et al 1998. In fracture treatment of the tibial shaft, CRP levels reach values of 7 mg/dL (Lindström et al 1997), and 5 mg/dL in malleolar fracture treatment (Buttenschoen et al 2000). CRP values appear to depend on region (femur versus ankle) and may also reflect the extent of surgical trauma (Scherer et al 2001).…”

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confidence: 99%

C-reactive protein as a parameter of surgical trauma: CRP response after different types of surgery in 349 hip fractures

Metak²,

2006

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Background Postoperative C-reactive protein (CRP) levels in serum appear to reflect surgical trauma. We examined CRP levels after different types of surgery in hip fractures.Methods We studied the CRP response after 349 operative procedures in proximal femur fractures with a normal postoperative course. 5 different operative techniques were used: 3-4 percutaneous cancellous screws, dynamic hip screw (DHS), proximal femur nail (PFN), hemiarthroplasty (HA), and total hip arthroplasty (THA).Results Peak CRP levels were reached on the second postoperative day in each group (medians: screws 8.7, DHS 12, PFN 14, HA 16, THA 16 mg/dL). Significant differences were found between screws and all others, and between DHS and arthroplasties.Interpretation CRP levels following surgical trauma can be used to quantify the degree of tissue damage and invasiveness of a procedure and reflect the perioperative stress experienced by the patient.

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“…Estos resultados concuerdan con los obtenidos por los escasos autores que han estudiado estos reactantes de fase aguda en el posoperatorio de esta cirugía. 10,12 Varios autores [13][14][15] estudiaron estos parámetros en diferentes cirugías de ortopedia (inclusive artroscopia de rodilla), y concluyeron en que la PCR alcanzaba valores normales (<10 mg/dl) a los 21 días de la cirugía. 8 Aparentemente si, a partir del día 4, existe un segundo aumento de PCR, hay que sospechar una complicación.…”

Section: Discussionunclassified

Evolución de los reactantes de fase aguda tras la reconstrucción no complicada del ligamento cruzado anterior por vía artroscópica. [Inflammatory blood marker patterns following uncomplicated arthroscopically-assisted anterior cruciate ligament reconstruction.]

Prado¹,

Teixeira²,

Flores³

et al. 2015

Rev. Asoc. Arg. Ort. y Traumatol

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Rev Asoc Argent Ortop Traumatol 70 ResumenIntroducción: El objetivo de este estudio fue determinar los niveles de los principales reactantes de fase aguda (proteína C reactiva y eritrosedimentación) en el posoperatorio de una reconstrucción artroscópica del ligamento cruzado anterior sin complicaciones y analizar si diferentes variables del tratamiento realizado podrían alterar esos valores. Materiales y Métodos: Se llevó a cabo un estudio prospectivo de todas las reconstrucciones del ligamento cruzado anterior realizadas en nuestro Hospital, entre diciembre de 2012 y diciembre de 2013. Los niveles en sangre de proteína C reactiva, eritrosedimentación y leucocitos fueron determinados un día antes de la intervención, y a las 24 horas y a los 15 y 30 días de la cirugía. Se recogieron diferentes variables de la intervención: tiempo de isquemia, tiempo de cirugía, tipo de injerto y diferentes gestos asociados a la reconstrucción (sutura meniscal, microfracturas, etc.). Resultados: De los tres reactantes analizados, la proteína C reactiva es la que presenta un ascenso más elevado en el posoperatorio, es la única que vuelve a valores basales a los 30 días de la intervención (p >0,05). En cuanto a las variables analizadas, sólo el tiempo de isquemia se relacionaba con valores más elevados de proteína C reactiva. Conclusiones: La monitorización de la proteína C reactiva es una prueba práctica y sensible para detectar complicaciones después de la cirugía de ligamento cruzado anterior. Ante valores elevados a partir de los 15 días y si existe sospecha de infección debe realizarse una punción articular.Palabras clave: Ligamento cruzado anterior. Proteína C reactiva. Artritis séptica. Nivel de evidencia: IV Inflammatory blood marker patterns following uncomplicated arthroscopically-assisted anterior cruciate ligament reconstruction AbstractBackground: The purpose of this report was to determine the levels of inflammatory blood markers over the time after a successful arthroscopic anterior ligament reconstruction and to analyze if any variable of surgical treatment alter this blood marker. Methods: A prospective review was conducted including all anterior cruciate ligament reconstructions performed in our institution between December 2012 and December 2013. C-reactive protein, erythrocyte sedimentation rate and white blood cell count were determined before surgery and at days 1, 15 and 30 postoperatively. Different variables of surgical treatment were collected: ischemic and surgical time, type of graft, associated injuries or type of treatment (meniscal suture, microfractures, etc.

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Group II phospholipase A2 in serum after knee surgery and intramedullary nailing of tibial shaft fracture

Cited by 9 publications

References 14 publications

The association between the levels of CRP, IL-10, PLA2, Fbg and prognosis in traumatic fracture of lower limb

The association between the levels of CRP, IL-10, PLA2, Fbg and prognosis in traumatic fracture of lower limb

C-reactive protein as a parameter of surgical trauma: CRP response after different types of surgery in 349 hip fractures

Evolución de los reactantes de fase aguda tras la reconstrucción no complicada del ligamento cruzado anterior por vía artroscópica. [Inflammatory blood marker patterns following uncomplicated arthroscopically-assisted anterior cruciate ligament reconstruction.]

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