The association between the levels of CRP, IL-10, PLA2, Fbg and prognosis in traumatic fracture of lower limb

Abstract

The aim of the present study was to examine changes of sera levels of C-reactive protein (CRP), interleukin-10 (IL-10), phospholipase A2 (PLA2) and fibrinogen β polypeptide chain gene (Fbg) in patients with traumatic fracture of lower limb, and to evaluate their association with prognosis. The changes in sera levels of CRP, IL-10, PLA2 and Fbg were observed at the time of injury, 24 h, and 5 and 7 days after surgery in 90 patients with traumatic fracture of lower limb. In addition, 50 cases, who presented for health examination, were included as the normal controls. The expression of sera levels of CRP, IL-10, PLA2 and Fbg in patients with traumatic fracture of lower limb, was markedly higher than that in the normal controls prior to surgery (P<0.05). The concentration of CRP significantly increased within 24 h after emergency, but decreased gradually as the wound healed, compared to the controls. Pre- and postoperative IL-10 levels increased within 24 h and then decreased gradually. The level of PLA2 in patients before and after surgery was increased, and then decreased gradually. The level of Fbg in patients with trauma was increased after 24 h and then decreased, and increased gradually. The correlation of serum CRP and IL-10 levels (r=0.634, P<0.05), and that of PLA2 and IL-10 levels (r=0.617, P<0.05) were positive. In conclusion, the expression of CRP, IL-10, PLA2 and Fbg levels in traumatic fracture of lower limb markedly increased and was closely associated with prognosis. CRP, IL-10, PLA2 and Fbg levels may therefore serve as useful indexes in determining the progression and prognosis of patients with traumatic fracture of lower limb.

High Dose of Intravenous Allogeneic Umbilical Cord-Derived Mesenchymal Stem Cells (CLV-100) Infusion Displays Better Immunomodulatory Effect among Healthy Volunteers: A Phase 1 Clinical Study

“…Based on our results, the hs-CRP level was only peaked at 2 days post-MSCs infusion, which later followed by the raised level of IL-10, which peaked on the same day to ease down the inflammation rate even it was not statistically significant. This outcome was also supported by Jiao and colleagues where the levels of CRP and IL-10 were positively correlated among patients with traumatic fracture of lower limb [ 34 ].…”

The trajectory of C‐reactive protein serum levels in older hip fracture patients with postoperative delirium

“…39 On the basis of their review, Neumaier and colleagues conclude that in conservative fracture treatment, CRP shows a slight elevation around fivefold of normal levels and that a rapid rise occurs after orthopedic surgery, reaching the maximum value on the second day after surgery. 39 On the basis of their review, Neumaier and colleagues conclude that in conservative fracture treatment, CRP shows a slight elevation around fivefold of normal levels and that a rapid rise occurs after orthopedic surgery, reaching the maximum value on the second day after surgery.…”

“…A recent study shows that in patients with a lower limb fracture, the preoperative levels of serum CRP were markedly higher than in a normal control group. 39 On the basis of their review, Neumaier and colleagues conclude that in conservative fracture treatment, CRP shows a slight elevation around fivefold of normal levels and that a rapid rise occurs after orthopedic surgery, reaching the maximum value on the second day after surgery. 40 These findings suggest that in hip fracture patients, the preoperative levels of acute-phase proteins are already influenced by an ongoing inflammatory process induced by the fracture as an immediate correlate of tissue damage.…”