C-reactive protein as a parameter of surgical trauma: CRP response after different types of surgery in 349 hip fractures

Neumaier, Markus; Metak, G.; Scherer, M. A.

doi:10.1080/17453670610013006

Cited by 106 publications

(100 citation statements)

References 12 publications

(13 reference statements)

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“…Levels of the APPs CRP, SAA, and YKL-40 increase as a result of the inflammatory response to infection or tissue damage, and have been used to evaluate surgery technique, infection and pathology progress. CRP and SAA levels increase in a number of pathological states, including surgical trauma (27)(28)(29)(30), esophageal neoplasia, infection with H3N2 swine influenza virus, alcoholic liver and systemic inflammation (11,(31)(32)(33)(34). In the present study, levels of all APPs increased significantly on day 1 postoperatively compared with baseline (preoperative levels) and decreased over the subsequent time point measurements.…”

Section: Discussionsupporting

confidence: 51%

Comparison of acute phase protein and hemodynamic variables in dogs undergoing video-assisted thoracoscopic vs. open pneumonectomy

Liu

Ren

Wang

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. It has been demonstrated that video-assisted thoracoscopic surgery (VATS) is feasible and safe in humans and animal models. The aim of the present study was to compare the surgical outcome using VATS with that of the standard transthoracic approach for pneumonectomy in dogs, to determine the acute-phase reaction in VATS pneumonectomy, and to analyze the difference between VATS and the standard transthoracic approach. A total of 14 dogs were divided into two groups (n=7); one group underwent VATS and the other group underwent a transthoracic pneumonectomy. Pre-, intraand post-operative physiologic parameters were monitored, in addition to the blood cell count and serum acute-phase protein (APP) concentrations. The APP and hemodynamic changes between the two approaches were analyzed. Mean surgical time in the VATS group (176.7 min) was significantly longer compared with the open group (132.4 min). All APP concentrations were significantly increased at day 1 postoperation and gradually decreased to preoperative concentrations. The serum concentration of C-reactive protein on day 3 and the white blood cell count on day 1 were significantly higher following surgery in the open group compared with the VATS group (P<0.05). No differences were observed in the physiological parameters between the two groups. Although VATS took longer, animals experienced smaller incision and less stress. Therefore, the VATS approach was satisfactory for total pneumonectomy.

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Section: Discussionsupporting

confidence: 51%

Comparison of acute phase protein and hemodynamic variables in dogs undergoing video-assisted thoracoscopic vs. open pneumonectomy

Liu

Ren

Wang

et al. 2017

Experimental and Therapeutic Medicine

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“…Thus, many studies have been conducted to identify an ideal biomarker for trauma diagnosis. C-reactive protein, ILs, and heat shock protein are potential biomarkers that help to make an early and correct diagnosis for the severity of organ injury and the level of inflammatory immune response [3][4][5]. However, as biomarkers, these proteins are limited by low sensitivity and specificity during examinations in the clinic.…”

Section: Discussionmentioning

confidence: 99%

“…To potentially reduce the mortality rate of traumatic injury, prognostic biomarkers that are easily measurable in clinic are important to indicate the need of immediate therapy. For decades, specific blood-based biomarkers such as C-reactive protein, interleukins (ILs), and heat shock protein have been investigated, but while these biomarkers do benefit early diagnosis of severe organ injury and inflammatory immune response [3][4][5], they have an unacceptable rate of false positives/negatives, poor sensitivity, and lack of tissue specificity. Therefore, the exploration for novel biomarkers with high sensitivity and specificity for the early diagnosis of trauma is urgently needed [6].…”

Section: Introductionmentioning

confidence: 99%

Identification of a miRNA signature in neutrophils after traumatic injury

Yang¹,

Liang²,

Han³

et al. 2013

ABBS

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Traumatic injury is the cause of significant mortality and morbidity. The molecular mechanisms underlying traumatic injury logically involve changes in gene expression that may be regulated through microRNAs (miRNAs). However, the association between miRNA deregulation and traumatic injury is largely unknown. The purpose of the present study is to address this issue. In this study, we used microarray profiling to evaluate the differential expressions of miRNAs in neutrophils obtained from patients with major trauma (injury severity scores >16), relative to healthy individuals. This neutrophilic miRNA signature was further validated using quantitative real-time reverse transcription-polymerase chain reaction (qRT-PCR). Genes and signaling pathways related to trauma-induced deregulated miRNAs were investigated in silico using the ontology-based and network mapping algorithms of Gene Ontology and Kyoto Encyclopedia of Genes or Genomes. Results showed that 13 miRNAs in neutrophils of major trauma patients were significantly and differentially expressed compared with the miRNA profiles of healthy controls. The results of qRT-PCR and in silico analysis revealed that miR-23a-5p, miR-30e-3p, miR-223-5p, miR-3945, miR-155-5p, and miR-150-5p were likely participants in the traumatic pathogenesis of these patients. In conclusion, neutrophils associated with traumatic injury were found to have a unique miRNA signature. Changes in signaling pathways due to deregulated miRNAs may be involved in the pathological processes of traumatic injury.

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“…On average, the level of CRP declines to 4 mg/dl on the sixth postoperative day. Rising levels above these values should alert doctors for underlining infections, thromboembolic events, or ischemia [21].…”

Section: Value Of C-reactive Protein (Crp) Analysis After Hip Fracturementioning

confidence: 99%

Treatment and prevention of postoperative complications in hip fracture patients: infections and delirium

Dovjak¹,

Iglseder

Mikosch

et al. 2013

Wien Med Wochenschr

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The course of older patients with hip fractures is often complicated by infections and delirium. Accurate care and high suspicion for these complications are essential, since these conditions are associated with an increase in mortality, length of hospital stay and nursing home placement, poorer mobility, and functional decline. Because of immunosenescence and higher infection rates, older patients need specific care, immediate diagnosis, and treatment of infections. Numerous guidelines of various medical societies outline the management of nosocomial infections, but there is a need of an individualized treatment plan because of comorbidities and polypharmacy. Hygiene measures have first priority to reduce the rate of infections. Treatment of geriatric syndromes like malnutrition, exsiccosis, gait disorders, falls, delirium, urine incontinence, and organ insufficiency are as important as immunization against pneumococci and influenza. Advanced age, cognitive impairment, hearing loss, peripheral vascular disease, prior delirium episodes, sight disorders, and polypharmacy are established risk factors for delirium; thus, older people with several chronic diseases are prone to delirium. A multifactorial approach, comprising standardized screening, oxygen support, intravenous fluid administration and augmented nutrition, monitoring of vital signs, pain treatment, optimized medication, and modification in perioperative management, significantly reduces delirium incidence during hospitalization for hip fracture. An interdisciplinary approach between surgeons and geriatricians may warrant optimized satisfaction of patients' needs.

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C-reactive protein as a parameter of surgical trauma: CRP response after different types of surgery in 349 hip fractures

Cited by 106 publications

References 12 publications

Comparison of acute phase protein and hemodynamic variables in dogs undergoing video-assisted thoracoscopic vs. open pneumonectomy

Comparison of acute phase protein and hemodynamic variables in dogs undergoing video-assisted thoracoscopic vs. open pneumonectomy

Identification of a miRNA signature in neutrophils after traumatic injury

Treatment and prevention of postoperative complications in hip fracture patients: infections and delirium

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