Gross anatomy and morphometric evaluation of the canine lacrimal and third eyelid glands

Park, Shin Ae; Taylor, Ken T.; Zwingenberger, Allison L.; Reilly, Christopher M.; Toupadakis, Chrisoula A.; Marfurt, Carl F.; Good, Kathryn L.; Murphy, Christopher J.

doi:10.1111/vop.12288

Cited by 11 publications

(31 citation statements)

References 14 publications

(25 reference statements)

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“…In this study, the dog's lacrimal gland was enveloped by a thin sheet of periorbital fascia and rectangular in shape which disagreed with the results of Murphy et al (2013) and Park et al (2016), who recorded that, lacrimal gland was non encapsulated and ranged in shape from round, triangular, or oval to heart-or dumbbellshaped. Also, this rectangular lacrimal gland differed from the shapes that have been investigated in other animals; bilobed in cattle (Pinard et al, 2003) and human (Lorber, 2007), elongated in camel (Alsafy, 2010;Ibrahim et al, 2006;Mohammadpour, 2008;Mohammadpour, 2011), ovoid in donkey (Alsafy, 2010;El-Bhery, 2015), triangular in Roe Deer ((Kleckowska-Nawrot et al, 2013), oval to spherical in Lori sheep (Abbasi et al, 2014) and elongated oval in sheep (El-Bhery, 2015).…”

Section: Discussioncontrasting

confidence: 99%

“…The shape of lacrimal gland was lobulated, flattened and irregular in outlines. Morphometrically, the average width and length of the lacrimal gland were 1.38 ± 0.13 cm and 1.52 ±0.12 cm, respectively (Cabral (Cabral et al, 2005;Murphy et al, 2013;Park et al, 2016).…”

Section: Discussionmentioning

confidence: 96%

“…While a long thin tail of the lacrimal gland has extended around the lateral margin of the orbit and located in the glandular lacrimal fossa. The lacrimal gland was lobulated, flat and irregular in outlines with morphological variations between different breeds of dogs (Park et al, 2016). Microscopically, the lacrimal gland is a multilobar tubuloacinar gland in most of the species.…”

Section: Introductionmentioning

confidence: 99%

“…The lacrimal gland is a part of the lacrimal apparatus that consists of both secretory and drainage portions in domestic mammals (Konig and Liebich, 2007). Macroscopically, the canine LG was situated inside the orbit on the dorsolateral aspect of the eyeball (Cabral et al, 2005;Murphy et al, 2013;Park et al, 2016). Also, in man Edward and Bedrossian (2005) and Records (2006) explained that the main lacrimal gland occupies the lateral third of the orbital roof and it lies in the lacrimal fossa of the frontal bone.…”

Section: Introductionmentioning

confidence: 99%

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The structural characterization of the lacrimal gland in the adult dog (Canis familiaris)

El-naseery

El-behery

El-Ghazali

et al. 2016

Benha Veterinary Medical Journal

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To elucidate the macroscopical and microscopical structure of dog's lacrimal gland, 15 adult dogs (Canis familiaris) were utilized in this study. Macroscopically, the lacrimal gland was located on the dorsolateral aspect of the eyeball and bounded dorsolaterally by the orbital ligament, zygomatic process of the frontal bone and frontal process of malar bone. Its shape was nearly rectangular with the average width (1.38 ± 0.13 cm) and length (1.52 ±0.12 cm). In between the dorsal and lateral rectus muscles, the lacrimal artery, vein and nerve were observed. Microscopically, the lacrimal gland was enveloped by the fibromuscular capsule and lobulated. Each lobule was formed of secretory endpieces and ducts. The secretory endpieces were mucous and serous. However, the mucous type was predominant. The lining cells of the secretory endpieces expressed a positive reaction to alcian blue and Periodic acid Shiff. A series of duct system within the lobules and septa was seen. The scanning electron microscopic examination revealed that the secretory endpieces covered with granular secretory substance. Several crystals with sharp taper ends were seen around the secretory endpieces.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The structural characterization of the lacrimal gland in the adult dog (Canis familiaris)

El-naseery

El-behery

El-Ghazali

et al. 2016

Benha Veterinary Medical Journal

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“…Eye diseases associated with quantitative and qualitative tear deficiency are characterized by instability of the tear film, with subsequent drying of the ocular surface. Among the main conditions resulting from lacrimal film deficiency in dogs, keratoconjunctivitis sicca, commonly known as dry eye syndrome, is clinically characterized by mucopurulent ocular discharge, conjunctivitis, pain, keratitis, and corneal ulcers …”

Section: Introductionmentioning

confidence: 99%

Ultrastructural morphology of goblet cells of the conjunctiva of dogs

Araújo

Corrêa

Galera

2019

Veterinary Ophthalmology

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Objective: To describe the morphology of goblet cells of the eyelid conjunctiva in dogs using transmission and scanning electron microscopy. Animal studied: Ten dogs, both male and female of different breeds, with no ocular changes were examined (20 eyes). Procedures: Ten samples of conjunctiva were collected and processed for scanning and transmission electron microscopy (SEM and TEM), while another 10 samples were stained with Schiff's periodic stain (SPA) and alcian blue, pH 2.5, and analyzed using light microscopy. Results: Scanning electron microscopy revealed several points of mucus extrusion in the free apical portion of the goblet cells as well as a wide distribution of lymphoid follicles and macrophages intermingling with the microvilli of palpebral epithelium cells. TEM revealed normal goblet cells that were predominantly oval with wide cytoplasm of different diameters, and large vesicles with heterogeneous granules and free edges, suggesting the release of mucus content onto the conjunctival surface.Cytoplasmic organelles, such as the Golgi apparatus, endoplasmic reticulum, and a high number of mitochondria were also observed. All the samples were positive for SPA and alcian blue staining. Conclusion: This is the first study to evaluate the goblet cells of the eyelid conjunctiva in healthy dogs using electron microscopy techniques. These results are useful for comparing the palpebral conjunctiva of dogs without ocular changes to palpebral conjunctiva of dogs and other species with ocular changes. K E Y W O R D Sdogs, electron microscopy, goblet cells, keratoconjunctivitis sicca, ocular surface How to cite this article: Araújo RLS, Corrêa JR, Galera PD. Ultrastructural morphology of goblet cells of the conjunctiva of dogs. Vet Ophthalmol.

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An eye on the dog as the scientist's best friend for translational research in ophthalmology: Focus on the ocular surface

Sebbag

Mochel

2020

Medicinal Research Reviews

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Preclinical animal studies provide valuable opportunities to better understand human diseases and contribute to major advances in medicine. This review provides a comprehensive overview of ocular parameters in humans and selected animals, with a focus on the ocular surface, detailing species differences in ocular surface anatomy, physiology, tear film dynamics and tear film composition. We describe major pitfalls that tremendously limit the translational potential of traditional laboratory animals (i.e., rabbits, mice, and rats) in ophthalmic research, and highlight the benefits of integrating companion dogs with clinical analogues to human diseases into preclinical pharmacology studies. This One Health approach can help accelerate and improve the framework in which ophthalmic research is translated to the human clinic. Studies can be conducted in canine subjects with naturally occurring or noninvasively induced ocular surface disorders (e.g., dry eye disease, conjunctivitis), reviewed herein, and tear fluid can be easily retrieved from canine eyes for various bioanalytical purposes. In this review, we discuss common tear collection methods, including capillary tubes and Schirmer tear strips, and provide guidelines for tear sampling and extraction to improve the reliability of analyte quantification (drugs, proteins, others).

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Gross anatomy and morphometric evaluation of the canine lacrimal and third eyelid glands

Abstract: The present study provides detailed normative anatomical and morphometric data for the LG and TELG. These data will aid researchers investigating alterations induced by disease states and should inform strategies for the local delivery of pharmacologic and cellular therapeutics.

Cited by 11 publications

References 14 publications

The structural characterization of the lacrimal gland in the adult dog (Canis familiaris)

The structural characterization of the lacrimal gland in the adult dog (Canis familiaris)

Ultrastructural morphology of goblet cells of the conjunctiva of dogs

An eye on the dog as the scientist's best friend for translational research in ophthalmology: Focus on the ocular surface

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