GRGDS-conjugated and curcumin-loaded magnetic polymeric nanoparticles for the hyperthermia treatment of glioblastoma cells

Senturk, Fatih; Çakmak, Soner; Kocum, Ismail Cengiz; Gümüşderelı́oğlu, Menemşe; Öztürk, Güler

doi:10.1016/j.colsurfa.2021.126648

Cited by 27 publications

(15 citation statements)

References 75 publications

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“…Then, the ligand can be attached to the surface via strong electrostatic interactions or with an appropriate chemical reaction between the surface functional groups and a chemically active moiety of the targeting molecule. 23 Peptides are widely used for targeting purposes in various drug delivery systems. There are many examples of SPIONs-peptide conjugates that are designed to deliver SPIONs effectively to the targeted cells/tissue/organs, for both diagnostic and therapeutic applications.…”

Section: Targetingmentioning

confidence: 99%

“…A remarkable number of these applications concentrate on the use of SPIONs for diagnostic and theranostic purposes. Their superparamagnetic properties make them advantageous for MRI, 22 magnetic hyperthermia, 23 and targeted drug delivery. 24 The incorporation of SPIONs into a drug carrier 25 and/or modifications on their surfaces 26 enable them to be targeted to many different tumour tissues such as prostate cancer, 25 breast cancer, 26 bone cancer, and brain cancer.…”

Section: Recent Delivery and Targeting Technologies For Spionsmentioning

confidence: 99%

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Superparamagnetic iron oxide nanoparticles for magnetic hyperthermia: recent advancements, molecular effects, and future directions in the omics era

et al. 2022

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Section: Targetingmentioning

confidence: 99%

Section: Recent Delivery and Targeting Technologies For Spionsmentioning

confidence: 99%

Superparamagnetic iron oxide nanoparticles for magnetic hyperthermia: recent advancements, molecular effects, and future directions in the omics era

et al. 2022

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“…These NPs enhance the therapeutic efficiency of the curcumin (a cytotoxic drug) with a 70% release within 72 h and with a heating temperature of about 43 • C in just 15 min. Interestingly, the GRGDS peptide has ameliorated the excellent cytotoxicity of these NPs against glioblastoma sixfold [106]. The combination of thermal and non-thermal properties of SPIONs and cell membrane respectively influence the cellular uptake and thereby potentiate the therapeutic efficiency of the curcumin in glioblastoma.…”

Section: Magnetic Nanoparticlesmentioning

confidence: 99%

Modernistic and Emerging Developments of Nanotechnology in Glioblastoma-Targeted Theranostic Applications

Lakshmi

Kim

2022

IJMS

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Brain tumors such as glioblastoma are typically associated with an unstoppable cell proliferation with aggressive infiltration behavior and a shortened life span. Though treatment options such as chemotherapy and radiotherapy are available in combating glioblastoma, satisfactory therapeutics are still not available due to the high impermeability of the blood–brain barrier. To address these concerns, recently, multifarious theranostics based on nanotechnology have been developed, which can deal with diagnosis and therapy together. The multifunctional nanomaterials find a strategic path against glioblastoma by adjoining novel thermal and magnetic therapy approaches. Their convenient combination of specific features such as real-time tracking, in-depth tissue penetration, drug-loading capacity, and contrasting performance is of great demand in the clinical investigation of glioblastoma. The potential benefits of nanomaterials including specificity, surface tunability, biodegradability, non-toxicity, ligand functionalization, and near-infrared (NIR) and photoacoustic (PA) imaging are sufficient in developing effective theranostics. This review discusses the recent developments in nanotechnology toward the diagnosis, drug delivery, and therapy regarding glioblastoma.

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“…These nanocarriers could target tumour cells wherein they released about 70% of their loaded curcumin in a controlled manner and reached hyperthermia temperature within ˜15 min. The prepared multifunctional nanocarriers showed improved heating efficiency under AFM with simultaneous therapeutic efficiency against T98G cells (Senturk et al, 2021).…”

Section: Biological Modificationmentioning

confidence: 99%

Surface modified iron-oxide based engineered nanomaterials for hyperthermia therapy of cancer cells

Dhiman¹

2022

Preprint

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Magnetic hyperthermia is emerging as a promising alternative to the currently available cancer treatment modalities. Superparamagnetic iron-oxide nanoparticles (SPIONs) are extensively studied functional nanomaterials for biomedical applications, owing to their tunable physio-chemical properties and magnetic properties. Out of various ferrite classes, spinel and inverse-spinel ferrites are widely used but are affected by particle size distribution, particle shape, particle-particle interaction, geometry and crystallinity. Notably, their heating ability makes them suitable candidates for heat-mediated cancer cell ablation or hyperthermia therapy. Exposing SPIONs to an externally applied magnetic field of appropriate frequency and intensity cause them to release heat to ablate cancer cells. Majorly, three heating mechanisms are exhibited by magnetic nanomaterials: Nèel relaxation, Brownian relaxation and hysteresis losses. In SPIONs, Nèel and Brownian relaxations dominate whereas hysteric losses are negligible. These nanomaterials possess high magnetization values capable of generating heat to ablate cancer cells. Furthermore, surface functionalization of these materials imparts the ability to selectively target cancer cells and deliver cargo to the affected area sparing the normal body cells. The surface of nanoparticles can be functionalized with various physical, chemical and biological coatings. Moreover, hyperthermia can be applied in combination with other cancer treatment modalities in order to enhance the efficiency of treatment.

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GRGDS-conjugated and curcumin-loaded magnetic polymeric nanoparticles for the hyperthermia treatment of glioblastoma cells

Cited by 27 publications

References 75 publications

Superparamagnetic iron oxide nanoparticles for magnetic hyperthermia: recent advancements, molecular effects, and future directions in the omics era

Superparamagnetic iron oxide nanoparticles for magnetic hyperthermia: recent advancements, molecular effects, and future directions in the omics era

Modernistic and Emerging Developments of Nanotechnology in Glioblastoma-Targeted Theranostic Applications

Surface modified iron-oxide based engineered nanomaterials for hyperthermia therapy of cancer cells

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