Superparamagnetic iron oxide nanoparticles for magnetic hyperthermia: recent advancements, molecular effects, and future directions in the omics era

Pucci, Carlotta; Degl’Innocenti, Andrea; Gümüş, Melike Belenli; Ciofani, Gianni

doi:10.1039/d1bm01963e

Cited by 81 publications

(57 citation statements)

References 122 publications

(206 reference statements)

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“…Alternatively, other SPIONs could be investigated to further enhance magnetic hyperthermia response in B. subtilis. Various SPIONs have been modified to improve magnetic hyperthermia properties [84][85][86][87] and these variations should be investigated for efficient coating of B. subtilis and improved magnetic hyperthermia after exposure to AMF.…”

Section: Resultsmentioning

confidence: 99%

Magnetothermal control of temperature-sensitive repressors in superparamagnetic iron nanoparticle-coatedBacillus subtilis

Greeson

Madsen

Makela

et al. 2022

Preprint

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Superparamagnetic iron oxide nanoparticles (SPIONs) are used as contrast agents in magnetic resonance imaging (MRI) and magnetic particle imaging (MPI) and resulting images can be used to guide magnetothermal heating. Alternating magnetic fields (AMF) cause local temperature increases in regions with SPIONs, and we investigated the ability of magnetic hyperthermia to regulate temperature-sensitive repressors (TSRs) of bacterial transcription. The TSR, TlpA39, was derived from a Gram-negative bacterium, and used here for thermal control of reporter gene expression in Gram-positive, Bacillus subtilis. In vitro heating of B. subtilis with TlpA39 controlling bacterial luciferase expression, resulted in a 14.6-fold (12-hour; h) and 1.8-fold (1-h) increase in reporter transcripts with a 9.0-fold (12-h) and 11.1-fold (1-h) increase in bioluminescence. To develop magnetothermal control, B. subtilis cells were coated with three SPION variations. Electron microscopy coupled with energy dispersive X-ray spectroscopy revealed an external association with, and retention of, SPIONs on B. subtilis. Furthermore, using long duration AMF we demonstrated magnetothermal induction of the TSRs in SPION-coated B. subtilis with a maximum of 4.6-fold increases in bioluminescence. After intramuscular injections of SPION-coated B. subtilis, histology revealed that SPIONs remained in the same locations as the bacteria. For in vivo studies, 1-h of AMF is the maximum exposure due to anesthesia constraints. Both in vitro and in vivo, there was no change in bioluminescence after 1-h of AMF treatment. Pairing TSRs with magnetothermal energy using SPIONs for localized heating with AMF can lead to transcriptional control that expands options for targeted bacteriotherapies.

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Section: Resultsmentioning

confidence: 99%

Magnetothermal control of temperature-sensitive repressors in superparamagnetic iron nanoparticle-coatedBacillus subtilis

Greeson

Madsen

Makela

et al. 2022

Preprint

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“…Following the first application for inductive heating of dogs’ lymph nodes [ 4 ], several phantom studies and animal experiments have been so far performed to investigate the mechanisms and the effectiveness of this technology [ 7 , 9 , 13 ]. To provide an overview of MFH in vitro and in vivo applications is out of the scope of this review, however, it is worth mentioning that the MFH technique proved more recently to be effective in clinics [ 12 ].…”

Section: Biomedical Applications Exploiting Magnetic Fieldmentioning

confidence: 99%

“…Many research papers published in the field of magnetic hyperthermia focus on the design, synthesis and characterization of suitable MNPs [ 13 , 15 , 16 , 17 ]. For effective hyperthermia applications, the injected MNPs should be biocompatible, biodegradable, with good stability; moreover, they should be successfully delivered to the tumor cells and provide good heating efficiency (which means that they should be able to provide large heat generation even with small amounts) [ 1 ].…”

Section: Biomedical Applications Exploiting Magnetic Fieldmentioning

confidence: 99%

“…For effective hyperthermia applications, the injected MNPs should be biocompatible, biodegradable, with good stability; moreover, they should be successfully delivered to the tumor cells and provide good heating efficiency (which means that they should be able to provide large heat generation even with small amounts) [ 1 ]. Their physicochemical properties can be tailored to improve their selectivity towards the target tissue, for instance by modulating their size or composition or through proper surface functionalization [ 13 ]. In more sophisticated applications, the MNPs can be engineered for drug encapsulation and the application of MFH can trigger controlled drug release [ 12 ].…”

Section: Biomedical Applications Exploiting Magnetic Fieldmentioning

confidence: 99%

“…In more sophisticated applications, the MNPs can be engineered for drug encapsulation and the application of MFH can trigger controlled drug release [ 12 ]. Moreover, MNPs can be used as MRI contrast agents for theranostic studies [ 13 ]. A crucial aspect is the MNPs administration for the MFH treatment effectiveness.…”

Section: Biomedical Applications Exploiting Magnetic Fieldmentioning

confidence: 99%

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Shaping and Focusing Magnetic Field in the Human Body: State-of-the Art and Promising Technologies

Rotundo

Brizi

Flori

et al. 2022

Sensors

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In recent years, the usage of radio frequency magnetic fields for biomedical applications has increased exponentially. Several diagnostic and therapeutic methodologies exploit this physical entity such as, for instance, magnetic resonance imaging, hyperthermia with magnetic nanoparticles and transcranial magnetic stimulation. Within this framework, the magnetic field focusing and shaping, at different depths inside the tissue, emerges as one of the most important challenges from a technological point of view, since it is highly desirable for improving the effectiveness of clinical methodologies. In this review paper, we will first report some of the biomedical practices employing radio frequency magnetic fields, that appear most promising in clinical settings, explaining the underneath physical principles and operative procedures. Specifically, we direct the interest toward hyperthermia with magnetic nanoparticles and transcranial magnetic stimulation, together with a brief mention of magnetic resonance imaging. Additionally, we deeply review the technological solutions that have appeared so far in the literature to shape and control the radio frequency magnetic field distribution within biological tissues, highlighting human applications. In particular, volume and surface coils, together with the recent raise of metamaterials and metasurfaces will be reported. The present review manuscript can be useful to fill the actual gap in the literature and to serve as a guide for the physicians and engineers working in these fields.

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Remote Magneto–Thermal Modulation of Reactive Oxygen Species Balance Enhances Tissue Regeneration In Vivo

Tommasini,

Sol‐Fernández,

Flavián‐Lázaro

et al. 2024

Adv Funct Materials

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One of the hallmarks of tissue repair is the production of reactive oxygen species (ROS), which modulate processes such as cell proliferation. Although several attempts have been made to manipulate ROS levels to increase tissue repair, the lack of techniques able to remotely manipulate the redox homeostasis with spatio–temporal fashion has hindered its progress. Herein, a new approach for tuning the ROS levels using magnetic nanoparticles (MNPs) that act as nanoheaters when exposed to an alternating magnetic field is presented. Two manganese–iron oxide (MnxFe3−xO4) MNPs (with a low and a high Mn2+ content) are designed and probed for the possibility of modulating the ROS balance by magneto–thermal stimulation in the invertebrate model organism Hydra vulgaris, able to fully regenerate. By evaluating the expression of selected genes involved in the maintenance of ROS homeostasis and proliferation pathways, a biphasic modulation of the ROS levels played by the MNPs is found. While MNPs with a lower Mn2+ content are able to positively modulate the regeneration potential under magnetostimulation, MNPs with a higher Mn2+ content cause a different redox imbalance, negatively affecting the regeneration dynamic. This innovative approach reveals a novel way of manipulating redox homeostasis that can advance in the field of tissue engineering.

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Superparamagnetic iron oxide nanoparticles for magnetic hyperthermia: recent advancements, molecular effects, and future directions in the omics era

Abstract: Superparamagnetic iron oxide nanoparticles have attracted attention in the biomedical field thanks to their ability to prompt hyperthermia in response to an alternated magnetic field. Hyperthermia is well-known for inducing...

Cited by 81 publications

References 122 publications

Magnetothermal control of temperature-sensitive repressors in superparamagnetic iron nanoparticle-coatedBacillus subtilis

Magnetothermal control of temperature-sensitive repressors in superparamagnetic iron nanoparticle-coatedBacillus subtilis

Shaping and Focusing Magnetic Field in the Human Body: State-of-the Art and Promising Technologies

Remote Magneto–Thermal Modulation of Reactive Oxygen Species Balance Enhances Tissue Regeneration In Vivo

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