Green Tea, the “Asian Paradox,” and Cardiovascular Disease

Sumpio, Bauer E.; Córdova, Alfredo; Berke-Schlessel, David W.; Feng, Qin; Chen, Quan Hai

doi:10.1016/j.jamcollsurg.2006.01.018

Cited by 100 publications

(68 citation statements)

References 128 publications

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“…Antioxidants counteract the detrimental effects of the free radical damage, as shown in the so-called Asian Paradox, where heavy cigarette smoking is paralleled with reduced rates of coronary disease and cancer amongst consumers of green tea [17][18][19] that is famous for its antioxidant properties. However, along with the fact that systemically administered antioxidant effects of green tea reduce the incident of dental caries, vitamin K2 may prove to be an even more potent antioxidant [20][21][22][23][24].…”

Section: A Systemic Approach and The Impact Of Oxidation Controlmentioning

confidence: 99%

Vitamin K2 and its Impact on Tooth Epigenetics

Gordeladze¹,

Landin²,

Johnsen³

et al. 2017

Vitamin K2 - Vital for Health and Wellbeing

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The impact of nutritional signals plays an important role in systemic-based «models» of dental caries. Present hypotheses now focus both on the oral environment and other organs, like the nervous system and brain. The tooth is subjected to shear forces, nourishing and cleansing, and its present "support system" (the hypothalamus/parotid axis) relays endocrine signaling to the parotid gland. Sugar consumption enhances hypothalamic oxidative stress (ROS), reversing dentinal fluid flow, thus creating an enhanced vulnerability to the oral bacterial flora. The acid, produced by the oral bacterial flora, then leads to erosion of the dentine, and an irreversible loss of dental enamel layers. This attack brings about inflammatory responses, yielding metalloproteinase-based "dissolution". However, vitamin K2 (i.e. MK-4/MK-7) may come to the rescue with its antioxidant property, locally (mouth cavity) or systemically (via the brain), thus sustaining/preserving hormone-induced dentinal fluid flow (encompassing oxidative stress) and boosting/magnifying bodily inflammatory responses. However, sugars may also reduce the tooth's natural defences through endocrine signaling, thus enhancing acid-supported enamel dentine erosion. Vitamin K2 sustains and improves the salivary buffering capacity via its impact on the secretion/flow of calcium and inorganic phosphates. Interestingly, primitive cultures' diets (low-sugar and high-K2 diets) preserve dental health.

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Section: A Systemic Approach and The Impact Of Oxidation Controlmentioning

confidence: 99%

Vitamin K2 and its Impact on Tooth Epigenetics

Gordeladze¹,

Landin²,

Johnsen³

et al. 2017

Vitamin K2 - Vital for Health and Wellbeing

View full text Add to dashboard Cite

show abstract

“…No significant side effects have been recorded and no safety issues have also been indicated in many of the studies involving use of resveratrol. Possible anti-platelet effect is suggested, hence, there is need for proper care when using other key prescription drugs or coagulation interfering products [93][94][95][96][97][98].…”

Section: Herbal Remedies With Potential Anti-arthritic Activitiesmentioning

confidence: 99%

“…Resins Stomach discomfort, nausea, acid reflux and diarrhea Capsicum annum [97][98][99][100][101][102][103][104][105] inhibition of NF-kB activation as a mechanism of action for generating the ant-inflammatory effect …”

Section: None Suggestedmentioning

confidence: 99%

Evidence Based Targeting of Cytokines for Conventional and the Potential Phytotherapies in Management of Rheumatoid Arthritis

Mutua¹,

Kk²,

Mr³

et al. 2017

J Arthritis

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Rheumatoid arthritis is an autoimmune disease that leads to chronic, systemic inflammatory reaction that primarily affects synovial joints. Current cytokine based therapies are effective and safe. However, they have a challenge of having short plasma half-life and even higher doses are required to manage the conditions. The processes involved in production using phage and viral technologies are expensive. Herbal medicines have been used for long and are considered safe and effective as medicines for many inflammatory related diseases. Many plants also posit as a potent anti-inflammatory agents. Evidence for use of herbal plants in both human and animal trials in studies suggest significant potential of application in herbal formulation in management of rheumatoid arthritis. Specifically, many studies suggest the direct effect of managing the agents of inflammation as a way of managing rheumatoid arthritis. Most evidence links the involvement of pro-inflammatory cytokines (interleukin-1, TNF-α, IFN-α, and NF-кB) to the long term. It has also been suggested that the use of protective cytokines such as (Interleukin-4, Interleukin-6, Interleukin-8). Key pathways involve cyclooxygenase 1 and 2, 5-Lipooxygenase, formations of metalloproteinases, and inhibition of formation of prostaglandin E2. Use of herbal medicines has potential of improving joint conditions in rheumatoid arthritis. Use of herbal extracts offers better, cheap and affordable solution for long term management of rheumatoid arthritis in patients. They also show potential of offering multifunctional approaches to the management of the conditions through their anti-oxidative and anti-inflammatory mechanisms. Further studies are required to demonstrate the mechanisms involved in activation of protective cytokines in the management of rheumatoid arthritis.

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“…Baharatlar aromatik bitkilerin yaprak, çiçek, tohum, kök, gövde, kabuk gibi çeşitli kısımlarından elde edilir. Lamiaceae, Apiaceae, Zingiberaceae, Liliaceae, Myrtaceae, Lauraceae, Brassicaceae gibi familyalar çok sayıda baharat bitkisi içermektedir [6,[9][10][11][12][13].…”

Section: Genel Bilgilerunclassified