Green tea polyphenol extract in vivo attenuates inflammatory features of neutrophils from obese rats

Albuquerque, K. F. F. S.; Marinovic, Marcelo Paradiso; Morandi, Ana Carolina; Bolin, Anaysa Paola; Otton, Rosemari

doi:10.1007/s00394-015-0940-z

Cited by 24 publications

(16 citation statements)

References 82 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Therefore, inhibiting neutrophil infiltration could be beneficial in the initial course of obesity. Recent studies have shown that bilberry extract markedly reduced hepatic neutrophil infiltration in nonalcoholic steatohepatitis (NASH) [ 22 ] and catechins have been shown to reduce the inflammatory potential of neutrophils in obesity [ 36 ]. We observed that HFD-feeding was associated with a significant elevation in plasma levels of the neutrophil chemoattractant mKC within the first 4 weeks after the dietary switch.…”

Section: Discussionmentioning

confidence: 99%

Effects of Anthocyanin and Flavanol Compounds on Lipid Metabolism and Adipose Tissue Associated Systemic Inflammation in Diet-Induced Obesity

Heijden

Morrison

Sheedfar

et al. 2016

Mediators of Inflammation

View full text Add to dashboard Cite

Background. Naturally occurring substances from the flavanol and anthocyanin family of polyphenols have been proposed to exert beneficial effects in the course of obesity. We hypothesized that their effects on attenuating obesity-induced dyslipidemia as well as the associated inflammatory sequelae especially have health-promoting potential. Methods. Male C57BL/6J mice (n = 52) received a control low-fat diet (LFD; 10 kcal% fat) for 6 weeks followed by 24 weeks of either LFD (n = 13) or high-fat diet (HFD; 45 kcal% fat; n = 13) or HFD supplemented with 0.1% w/w of the flavanol compound epicatechin (HFD+E; n = 13) or an anthocyanin-rich bilberry extract (HFD+B; n = 13). Energy substrate utilization was determined by indirect calorimetry in a subset of mice following the dietary switch and at the end of the experiment. Blood samples were collected at baseline and at 3 days and 4, 12, and 20 weeks after dietary switch and analyzed for systemic lipids and proinflammatory cytokines. Adipose tissue (AT) histopathology and inflammatory gene expression as well as hepatic lipid content were analyzed after sacrifice. Results. The switch from a LFD to a HFD lowered the respiratory exchange ratio and increased plasma cholesterol and hepatic lipid content. These changes were not attenuated by HFD+E or HFD+B. Furthermore, the polyphenol compounds could not prevent HFD-induced systemic rise of TNF-α levels. Interestingly, a significant reduction in Tnf gene expression in HFD+B mice was observed in the AT. Furthermore, HFD+B, but not HFD+E, significantly prevented the early upregulation of circulating neutrophil chemoattractant mKC. However, no differences in AT histopathology were observed between the HFD types. Conclusion. Supplementation of HFD with an anthocyanin-rich bilberry extract but not with the flavanol epicatechin may exert beneficial effects on the systemic early inflammatory response associated with diet-induced obesity. These systemic effects were transient and not observed after prolongation of HFD-feeding (24 weeks). On the tissue level, long-term treatment with bilberry attenuated TNF-α expression in adipose tissue.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of Anthocyanin and Flavanol Compounds on Lipid Metabolism and Adipose Tissue Associated Systemic Inflammation in Diet-Induced Obesity

Heijden

Morrison

Sheedfar

et al. 2016

Mediators of Inflammation

View full text Add to dashboard Cite

show abstract

“…At a molecular level, EGCG promotes the expression and the activity of several anti-oxidant and anti-inflammatory enzymes. EGCG is also proved to counteract the activation of Toll-like receptor 4 (TLR4) (Marinovic et al, 2015 ) and nuclear factor-κB (NF-κB) (Albuquerque et al, 2016 ), pathways associated with the production of inflammatory cytokines. In a mouse model of Sjögren syndrome, treatment with EGCG increased the abundance of AQP5 at the apical plasma membrane of the acinar cells.…”

Section: Dietary Polyphenols and Aquaporinsmentioning

confidence: 99%

Aquaporins as Targets of Dietary Bioactive Phytocompounds

Tesse

Grossini

Tamma

et al. 2018

Front. Mol. Biosci.

View full text Add to dashboard Cite

Plant-derived bioactive compounds have protective role for plants but may also modulate several physiological processes of plant consumers. In the last years, a wide spectrum of phytochemicals have been found to be beneficial to health interacting with molecular signaling pathways underlying critical functions such as cell growth and differentiation, apoptosis, autophagy, inflammation, redox balance, cell volume regulation, metabolic homeostasis, and energy balance. Hence, a large number of biologically active phytocompounds of foods have been isolated, characterized, and eventually modified representing a natural source of novel molecules to prevent, delay or cure several human diseases. Aquaporins (AQPs), a family of membrane channel proteins involved in many body functions, are emerging among the targets of bioactive phytochemicals in imparting their beneficial actions. Here, we provide a comprehensive review of this fast growing topic focusing especially on what it is known on the modulatory effects played by several edible plant and herbal compounds on AQPs, both in health and disease. Phytochemical modulation of AQP expression may provide new medical treatment options to improve the prognosis of several diseases.

show abstract

“…Furthermore, altered activity and levels of G6PD has been considered as one of the markers of inflammation and many age related diseases including neurological disorders as described in this review. 64 , 65 , 66 , 67 , 68 , 69 …”

Section: G6pd In Metabolic Stress and Ros Generationmentioning

confidence: 99%

Glucose 6 phosphatase dehydrogenase (G6PD) and neurodegenerative disorders: Mapping diagnostic and therapeutic opportunities

Tiwari

2017

Genes & Diseases

View full text Add to dashboard Cite

Glucose 6 phosphate dehydrogenase (G6PD) is a key and rate limiting enzyme in the pentose phosphate pathway (PPP). The physiological significance of enzyme is providing reduced energy to specific cells like erythrocyte by maintaining co-enzyme nicotinamide adenine dinucleotide phosphate (NADPH). There are preponderance research findings that demonstrate the enzyme (G6PD) role in the energy balance, and it is associated with blood-related diseases and disorders, primarily the anemia resulted from G6PD deficiency. The X-linked genetic deficiency of G6PD and associated non-immune hemolytic anemia have been studied widely across the globe. Recent advancement in biology, more precisely neuroscience has revealed that G6PD is centrally involved in many neurological and neurodegenerative disorders. The neuroprotective role of the enzyme (G6PD) has also been established, as well as the potential of G6PD in oxidative damage and the Reactive Oxygen Species (ROS) produced in cerebral ischemia. Though G6PD deficiency remains a global health issue, however, a paradigm shift in research focusing the potential of the enzyme in neurological and neurodegenerative disorders will surely open a new avenue in diagnostics and enzyme therapeutics. Here, in this study, more emphasis was made on exploring the role of G6PD in neurological and inflammatory disorders as well as non-immune hemolytic anemia, thus providing diagnostic and therapeutic opportunities.

show abstract

Green tea polyphenol extract in vivo attenuates inflammatory features of neutrophils from obese rats

Cited by 24 publications

References 82 publications

Effects of Anthocyanin and Flavanol Compounds on Lipid Metabolism and Adipose Tissue Associated Systemic Inflammation in Diet-Induced Obesity

Effects of Anthocyanin and Flavanol Compounds on Lipid Metabolism and Adipose Tissue Associated Systemic Inflammation in Diet-Induced Obesity

Aquaporins as Targets of Dietary Bioactive Phytocompounds

Glucose 6 phosphatase dehydrogenase (G6PD) and neurodegenerative disorders: Mapping diagnostic and therapeutic opportunities

Contact Info

Product

Resources

About