Green tea infusion improves cyclophosphamide-induced damage on male mice reproductive system

Zanchi, Mariane Magalhães; Manfredini, Vanusa; Brum, Daniela dos Santos; Vargas, Laura; Spiazzi, Cristiano Chiapinotto; Soares, Melina Bucco; Izaguirry, Aryele Pinto; Santos, Francielli Weber

doi:10.1016/j.toxrep.2014.12.016

Cited by 38 publications

(36 citation statements)

References 46 publications

(48 reference statements)

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“…The present study committed by other previous investigations, long-term treatment of MSG is correlated with several reversals in the nervous system [39][40], liver and kidneys [11,41] due to an elevation of ROS production [42]. Manuscript to be reviewed Also, Umukoro et al [43] demonstrated that orally administration of 500 mg/kg of MSG to mice elevated the malondialdehyde and diminished the GSH levels in brain tissue.…”

Section: Discussionsupporting

confidence: 72%

“…The green tea extract (GTE) was processed as described before by Zanch et al [11]. The stock solution of MSG was provided by dissolving 60 g in 1000 mL of distilled water.…”

Section: Preparation Of Green Tea Extract Msg and Green Zno Np Complexmentioning

confidence: 99%

“…Therefore, it is obligatory to evaluate its toxicity of ZnO NPs in distinctive organs for long-and the short-period of study. Recently, the effects of ZnO NPs on the liver and renal tissues had been evaluated in the laboratory [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

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Peer Review #1 of "Evaluation of the effects of the green nanoparticles zinc oxide on monosodium glutamate-induced toxicity in the brain of rats (v0.2)"

2019

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Background: Monosodium glutamate (MSG) is used extensively as a food additive in the diets of many countries around the world. Aim of the study was to determine the effects of green zinc oxide nanoparticles on MSG-induced oxidative damage, neurotransmitter changes, and histopathological alternation in the cerebral cortexes of rats. Methods: MSG was administered orally at two doses of 6 and 17.5 mg/kg body weight. The higher dose was associated with a significant decline in the activities of superoxide dismutase, catalase, and glutathione peroxidase, as well as the levels of brain-derived neurotrophic factor (BDNF) and glutathione (GSH) in the cerebral cortex of rats. Results: The administration of zinc oxide nanoparticles/green tea extract (ZnO NPs/GTE) to 17.5 mg/kg MSG-treated rats was associated with significant improvements in all parameters previously shown to be altered by MSG. The higher dose of MSG induced significant histopathological variation in brain tissue. Co-treatment of rats with ZnO NPs/GTE and MSG-HD inhibited the reduction of neurotransmitters and acetylcholinesterase by MSG. Conclusions: ZnO NPs/GTE have the potential to protect against oxidative stress and neuronal necrosis induced by MSG-HD. ZnO NPs/GTE conferred a greater benefit than the control treatment or ZnO NPs or GTE administered separately.

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Section: Discussionsupporting

confidence: 72%

“…The green tea extract (GTE) was processed as described before by Zanch et al [11]. The stock solution of MSG was provided by dissolving 60 g in 1000 mL of distilled water.…”

Section: Preparation Of Green Tea Extract Msg and Green Zno Np Complexmentioning

confidence: 99%

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Peer Review #1 of "Evaluation of the effects of the green nanoparticles zinc oxide on monosodium glutamate-induced toxicity in the brain of rats (v0.2)"

2019

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“…Fahmy et al (2014) found a significant decrease in the percentage of sperm abnormalities in orally administrated soybean extracts. Zanchi et al (2015) demonstrated that polyphenols improved CP-induced damage on reproductive system, and its effect is probably due to high concentrations of catechins and antioxidant activity. According to the above results, it can be deduced that the combination of grape seed proanthocyanidins and siberian ginseng eleutherosides as well as green tea polyphenols and eleutherosides was able to weaken the reproductive toxicity induced by MTX.…”

Section: Discussionmentioning

confidence: 97%

Screening of cytoprotectors against methotrexate-induced cytogenotoxicity from bioactive phytochemicals, by umu test combined with micronucleus Assay

Yang

2015

Preprint

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To develop new cytoprotectors to reduce the risk of second cancers caused by methotrexate-induced cytogenotoxicity, cytoprotective effects of ten kinds of phytochemicals and their combinations were evaluated by umu test combined with micronucleus assay. It is demonstrated that allicin, proanthocyanidins, polyphenols, eleutherosides and isoflavones owned higher antimutagenic activities than other phytochemicals. At the highest dose tested, the MTX genetoxicity was inhibited by 34.03%~67.12%. Of all the bioactive phytochemical combinations, the combination of grape seed proanthocyanidins and eleutherosides from siberian ginseng as well as green tea polyphenols and eleutherosides showed stronger antimutagenic effects, the inhibition rate of methotrexate-induced genotoxicity separately reached 74.7 ± 6.5 % and 71.8 ± 4.7%. The Kunming mice treated by MTX along with bioactive phytochemicals combinations showed significant reduction in micronucleus induction and sperm abnormality rate compared to MTX treated control groups without cytoprotector candidates (p<0.01). Moreover, obvious increases in thymus and spleen indices were observed in cytoprotector candidates treated groups. The results indicated that bioactive phytochemicals combinations owned potentials to be used as new cytoprotectors, besides umu test was the same effective assay to evaluate antimutagenic potential of phytochemicals as Ames test.

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“…Fahmy et al (2014) found a significant decrease in the percentage of sperm abnormalities in orally administrated soybean extracts. Zanchi et al (2015) Manuscript to be reviewed damage on reproductive system, and its effect is probably due to high concentrations of catechins and antioxidant activity.…”

Section: Discussionmentioning

confidence: 99%

Peer Review #2 of "Screening of cytoprotectors against methotrexate-induced cytogenotoxicity from bioactive phytochemicals (v0.1)"

Sarkar¹

2016

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As one of well known anti-neoplastic drugs, the cytogenotoxicity of methotrexate (MTX) has received more attention in recent years. To develop new cytoprotector to reduce the risk of second cancers caused by methotrexate, umu test combined with micronucleus assay was employed to estimated cytoprotective effects of ten kinds of bioactive phytochemicals and their combinations. The results showed that allicin, proanthocyanidins, polyphenols, eleutherosides and isoflavones owned higher antimutagenic activities than other phytochemicals. At the highest dose tested, the MTX genetoxicity was suppressed by 34.03%~67.12%. Of all the bioactive phytochemical combinations, the combination of grape seed proanthocyanidins and eleutherosides from siberian ginseng as well as green tea polyphenols and eleutherosides exhibited stronger antimutagenic effects, the inhibition rate of methotrexate-induced genotoxicity separately reached 74.7 ± 6.5 % and 71.8 ± 4.7%. Pretreatment of Kunming mice with phytochemical combinations revealed a significant reduction in micronucleus and sperm abnormality rate following exposure to MTX (p<0.01). Moreover, obvious increases in thymus and spleen indices were observed in cytoprotector candidates treated groups. The results indicated that bioactive phytochemicals combinations owned potentials to be used as new cytoprotectors.

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Green tea infusion improves cyclophosphamide-induced damage on male mice reproductive system

Abstract: Graphical abstract

Cited by 38 publications

References 46 publications

Peer Review #1 of "Evaluation of the effects of the green nanoparticles zinc oxide on monosodium glutamate-induced toxicity in the brain of rats (v0.2)"

Peer Review #1 of "Evaluation of the effects of the green nanoparticles zinc oxide on monosodium glutamate-induced toxicity in the brain of rats (v0.2)"

Screening of cytoprotectors against methotrexate-induced cytogenotoxicity from bioactive phytochemicals, by umu test combined with micronucleus Assay

Peer Review #2 of "Screening of cytoprotectors against methotrexate-induced cytogenotoxicity from bioactive phytochemicals (v0.1)"

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