Green tea extract modulates oxidative tissue injury in beta-thalassemic mice by chelation of redox iron and inhibition of lipid peroxidation

Koonyosying, Pimpisid; Kongkarnka, Sarawut; Uthaipibull, Chairat; Svasti, Saovaros; Fucharoen, Suthat; Srichairatanakool, Somdet

doi:10.1016/j.biopha.2018.10.017

Cited by 34 publications

(39 citation statements)

References 62 publications

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“…Importantly, we have recently reported that EGCG-rich GTE was able to reduce pancreatic iron accumulation and lipidperoxidation products in β-thalassemic mice with iron overload, leading to an increase in plasma insulin production. 47 In contrary, treatment of the HIT-T15 pancreatic β-cell line with EGCG (5-100 μM) was found to increase apoptotic cell death and cellular ROS (especially H 2 O 2 ) production but decreased cell viability. This suggests that EGCG may mediate Fe 2+ formation and H 2 O 2 generation via Haber-Weiss reaction.…”

Section: Discussionmentioning

confidence: 92%

Decrement in Cellular Iron and Reactive Oxygen Species, and Improvement of Insulin Secretion in a Pancreatic Cell Line Using Green Tea Extract

Koonyosying¹,

Uthaipibull

Fucharoen

et al. 2019

Pancreas

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Section: Discussionmentioning

confidence: 92%

Decrement in Cellular Iron and Reactive Oxygen Species, and Improvement of Insulin Secretion in a Pancreatic Cell Line Using Green Tea Extract

Koonyosying¹,

Uthaipibull

Fucharoen

et al. 2019

Pancreas

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“…Many studies reported the antioxidant properties of EGCG and its benefits in diseases characterized by oxidative stress and diminishing levels of lipid peroxidation [72][73][74][75][76]. However, this molecule is also known for its pro-oxidant effects, being responsible, in some cases, for hepatic damage due to increased levels of free radicals and inflammation in both animal models and human patients [77][78][79][80][81].…”

Section: Discussionmentioning

confidence: 99%

Epigallocatechin Gallate Slows Retinal Degeneration, Reduces Oxidative Damage, and Modifies Circadian Rhythms in P23H Rats

et al. 2020

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Retinitis pigmentosa (RP) includes a group of genetic disorders that involve the loss of visual function due to mutations mainly in photoreceptors but also in other retinal cells. Apoptosis, retinal disorganization, and inflammation are common in the progression of the disease. Epigallocatechin gallate (EGCG) has been proved as beneficial in different eye diseases. Pigmented heterozygous P23H rat was used as an animal model of RP. Visual function was assessed by optomotor and electroretinogram (ERG) and circadian rhythms were evaluated by telemetry. Hepatic oxidative damage and antioxidant defenses were assessed using biochemical tests. The visual function of the EGCG P23H group was preserved, with a deterioration in the activity period and lower values in the interdaily stability parameter. Control rats treated with EGCG were less active than the sham group. EGCG increased antioxidant levels in P23H rats but reduced total hepatic antioxidant capacity by almost 42% in control rats compared to the sham group. We conclude that treatment with EGCG improves visual function and antioxidant status in P23H rats but diminishes antioxidant defenses in wild-type control animals, and slightly worsens activity circadian rhythms. Further studies are necessary to clarify the beneficial effects in disease conditions and in healthy organisms.

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“…Under iron-overloaded conditions, redox-active forms of iron can non-enzymatically catalyze ROS generation, which can then lead to organ dysfunction and eventually death. Moreover, certain other natural products, in conjunction with iron chelators, can relieve oxidative organ damage [ 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 ]. Furthermore, dietary antioxidants present in fruits and vegetables play important roles in disease prevention, radical scavenging and oxidative activation of the nuclear factor erythroid 2–related factor 2 in the signaling pathway [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Effects of Anthocyanin-Rich Riceberry™ Rice Flour Prepared Using Dielectric Barrier Discharge Plasma Technology on Iron-Induced Oxidative Stress in Mice

et al. 2021

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Redox-active iron generates reactive oxygen species that can cause oxidative organ dysfunction. Thus, the anti-oxidative systems in the body and certain dietary antioxidants, such as anthocyanins, are needed to control oxidative stress. We aimed to investigate the effects of dielectric barrier discharge (DBD) plasma technology in the preparation of Riceberry™ rice flour (PRBF) on iron-induced oxidative stress in mice. PRBF using plasma technology was rich in anthocyanins, mainly cyanidine-3-glucoside and peonidine-3-glucoside. PRBF (5 mg AE/mg) lowered WBC numbers in iron dextran (FeDex)-loaded mice and served as evidence of the reversal of erythrocyte superoxide dismutase activity, plasma total antioxidant capacity, and plasma and liver thiobarbituric acid-reactive substances in the loading mice. Consequently, the PRBF treatment was observed to be more effective than NAC treatment. PRBF would be a powerful supplementary and therapeutic antioxidant product that is understood to be more potent than NAC in ameliorating the effects of iron-induced oxidative stress.

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Green tea extract modulates oxidative tissue injury in beta-thalassemic mice by chelation of redox iron and inhibition of lipid peroxidation

Cited by 34 publications

References 62 publications

Decrement in Cellular Iron and Reactive Oxygen Species, and Improvement of Insulin Secretion in a Pancreatic Cell Line Using Green Tea Extract

Decrement in Cellular Iron and Reactive Oxygen Species, and Improvement of Insulin Secretion in a Pancreatic Cell Line Using Green Tea Extract

Epigallocatechin Gallate Slows Retinal Degeneration, Reduces Oxidative Damage, and Modifies Circadian Rhythms in P23H Rats

Antioxidant Effects of Anthocyanin-Rich Riceberry™ Rice Flour Prepared Using Dielectric Barrier Discharge Plasma Technology on Iron-Induced Oxidative Stress in Mice

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