Antioxidant Effects of Anthocyanin-Rich Riceberry™ Rice Flour Prepared Using Dielectric Barrier Discharge Plasma Technology on Iron-Induced Oxidative Stress in Mice

Settapramote, Natwalinkhol; Utama‐ang, Niramon; Petiwathayakorn, Touchwin; Settakorn, Kornvipa; Svasti, Saovaros; Srichairatanakool, Somdet; Koonyosying, Pimpisid

doi:10.3390/molecules26164978

Cited by 4 publications

(6 citation statements)

References 81 publications

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“…C3G, which is a flavonoid, should theoretically inhibit ferroptosis. Recently, Setapramoten et al (Settapramote et al 2021 ) discovered the antioxidant and protective effect of C3G on an iron dextran-loaded mouse model. In the same year, Shan X et al confirmed the antiferroptotic effect of C3G in myocardial I/R injury (Zhang et al 2021b ).…”

Section: Discussionmentioning

confidence: 99%

Cyanidin-3-glucoside inhibits ferroptosis in renal tubular cells after ischemia/reperfusion injury via the AMPK pathway

Wang

et al. 2023

Mol Med

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Background Ferroptosis, which is characterized by lipid peroxidation and iron accumulation, is closely associated with the pathogenesis of acute renal injury (AKI). Cyanidin-3-glucoside (C3G), a typical flavonoid that has anti-inflammatory and antioxidant effects on ischemia‒reperfusion (I/R) injury, can induce AMP-activated protein kinase (AMPK) activation. This study aimed to show that C3G exerts nephroprotective effects against I/R-AKI related ferroptosis by regulating the AMPK pathway. Methods Hypoxia/reoxygenation (H/R)-induced HK-2 cells and I/R-AKI mice were treated with C3G with or without inhibiting AMPK. The level of intracellular free iron, the expression of the ferroptosis-related proteins acyl-CoA synthetase long chain family member 4 (ACSL4) and glutathione peroxidase 4 (GPX4), and the levels of the lipid peroxidation markers 4-hydroxynonenal (4-HNE), lipid reactive oxygen species (ROS) and malondialdehyde (MDA) were examined. Results We observed the inhibitory effect of C3G on ferroptosis in vitro and in vivo, which was characterized by the reversion of excessive intracellular free iron accumulation, a decrease in 4-HNE, lipid ROS, MDA levels and ACSL4 expression, and an increase in GPX4 expression and glutathione (GSH) levels. Notably, the inhibition of AMPK by CC significantly abrogated the nephroprotective effect of C3G on I/R-AKI models in vivo and in vitro. Conclusion Our results provide new insight into the nephroprotective effect of C3G on acute I/R-AKI by inhibiting ferroptosis by activating the AMPK pathway.

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Section: Discussionmentioning

confidence: 99%

Cyanidin-3-glucoside inhibits ferroptosis in renal tubular cells after ischemia/reperfusion injury via the AMPK pathway

Wang

et al. 2023

Mol Med

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“…In controversy, green tea polyphenols can interfere with the duodenal absorption of dietary iron which will result in iron−deficiency anemia in healthy people; inversely, the compounds exert an iron−chelating activity that can improve iron overload-associated oxidative stress in thalassemia patients. To induce iron overload in mice, ip injections of iron dextran are more controllable and require shorter periods of time than it takes to administer a ferrocene-supplemented diet (Saewong et al, 2010;Koonyosying et al, 2018;Settapramote et al, 2021). In this study, the nutraceutical effects of GTE were investigated in an attempt to address ineffective erythropoiesis, anemia and iron overload−related complications in β−thalassemia patients.…”

Section: Discussionmentioning

confidence: 99%

“…The mice were allowed to equilibrate for further 23 days and were then treated with DI every day for 60 days. Similarly, BKO mice were induced to become iron overloaded by intraperitoneal (ip) injection of iron dextran (10 mg/d each) for 20 days according to our previously established method (Settapramote et al, 2021). Mice were then allowed to equilibrate for further 23 days.…”

Section: Iron Loading and Treatmentmentioning

confidence: 99%

“…Furthermore, β−thalassemia patients can develop iron overload from multiple RBC transfusions, while β−globin gene knockout (BKO) thalassemic mice can develop iron overload by consuming a ferrocene-supplemented diet and through intraperitoneal injections of iron dextran (Koonyosying et al, 2018;Settapramote et al, 2021). As a consequence, excessive iron is accumulated in certain major organs including the liver, heart, macrophage, endocrine glands, and kidneys.…”

Section: Introductionmentioning

confidence: 99%

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Effects of green tea extract treatment on erythropoiesis and iron parameters in iron-overloaded β-thalassemic mice

et al. 2022

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β-Thalassemia is characterized by ineffective erythropoiesis leading to chronic anemia. Thus, increased iron absorption from the duodenum and via blood transfusions is required to maintain normal blood hemoglobin (Hb) levels and iron chelators in the removal of excessive iron. Certain agents are also needed for the improvement of stress erythropoiesis and iron dysregulation. Green tea extract (GTE), which is rich in epigallocatechin-3-gallate (EGCG), is known to possess radical scavenging and iron-chelating activities. We aimed to assess the effects of green tea extract on erythroid regulators, iron mobilization and anti–lipid peroxidation in the liver, spleen, and kidneys of iron-loaded β-globin gene knockout thalassemic (BKO) mice. Our results indicate that treatments of green tea extract and/or deferiprone (DFP) diminished levels of plasma erythropoietin (EPO) and erythroferrone (ERFE), and consistently suppressed kidney Epo and spleen Erfe mRNA expressions (p < .05) in iron- loaded BKO mice when compared with untreated mice. Coincidently, the treatments decreased plasma ferritin (Ft) levels, iron content levels in the liver (p < .05), spleen (p < .05), and kidney tissues of iron–loaded BKO mice. Furthermore, lipid-peroxidation products in the tissues and plasma were also decreased when compared with untreated mice. This is the first evidence of the orchestral role of green tea extract abundant with epigallocatechin-3-gallate in improving ineffective erythropoiesis, iron dysregulation and oxidative stress in iron-overloaded β-thalassemic mice.

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“…Riceberry (Oryza sativa L.) is a dark-purple pigmented rice variety that was created by combining two rice varietiesa purple rice variety (Jao Hom nin) and Thai Hom mali rice (Khoa Dawk Mali 105) (Riceberry, n.d.; Leardkamolkarn et al, 2011). Riceberry is abundant in fiber and antioxidants, such as anthocyanins, beta-carotene, gamma-oryzanol, vitamin E, tannins, zinc and folate (Settapramote et al, 2021). Hence, Riceberry is a healthy stable food and suitable for people of all ages as it can be ingested to preserve health and used in place of white or brown rice (Riceberry, n.d.).…”

Section: Introductionmentioning

confidence: 99%

Gluten-free pancakes and waffles prepared from Riceberry flour instant mix with xanthan gum addition: physical, sensory and chemical properties

2023

ANRES

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Importance of the work: Pancakes and waffles are popular breakfast and dessert items commonly made from wheat flour containing gluten. Riceberry flour has the potential to be used to create gluten-free baked products. However, the lack of the gluten structure influences the quality of waffles and pancakes. Objectives: To investigate the effect of xanthan gum on the quality of gluten-free waffles and pancakes made from Riceberry flour. Materials & Methods: Physical quality measurements were made of the pancake spread ratio, the percentage weight loss during cooking and the color. Sample texture was measured using a CT-3 Brookfield texture analyzer. The sensory acceptability was conducted using a 9-point hedonic scale. The moisture content and water activity of all samples were measured. Results: Xanthan gum addition resulted in decreases in the percentage weight loss during cooking and in the spread ratio of the pancakes. The pancake shear force decreased with xanthan gum addition (0.25-1%). Furthermore, this addition decreased the hardness, chewiness and gumminess of the waffles, while increasing their springiness. Waffles and pancakes with 0.5% added xanthan gum received the highest acceptable scores that were significantly higher than the control samples. Main finding: The optimum amount of xanthan gum addition to improve the quality of gluten-free waffles and pancakes made from Riceberry flour was 0.5%. This addition retained more moisture in the products than the control and provided a viscoelastic network that mimicked gluten in the final products.

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Antioxidant Effects of Anthocyanin-Rich Riceberry™ Rice Flour Prepared Using Dielectric Barrier Discharge Plasma Technology on Iron-Induced Oxidative Stress in Mice

Cited by 4 publications

References 81 publications

Cyanidin-3-glucoside inhibits ferroptosis in renal tubular cells after ischemia/reperfusion injury via the AMPK pathway

Cyanidin-3-glucoside inhibits ferroptosis in renal tubular cells after ischemia/reperfusion injury via the AMPK pathway

Effects of green tea extract treatment on erythropoiesis and iron parameters in iron-overloaded β-thalassemic mice

Gluten-free pancakes and waffles prepared from Riceberry flour instant mix with xanthan gum addition: physical, sensory and chemical properties

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