Green tea extract attenuates hepatic steatosis by decreasing adipose lipogenesis and enhancing hepatic antioxidant defenses in ob/ob mice

Park, Hea Jin; DiNatale, Dana A.; Chung, Min‐Yu; Park, Youngki; Lee, Ji-Young; Koo, Sung I.; O'Connor, Meeghan; Manautou, José E.; Bruno, Richard S.

doi:10.1016/j.jnutbio.2010.03.009

Cited by 143 publications

(120 citation statements)

References 51 publications

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“…The inhibition of NQO found in this study may lead to an enhanced level of ROS. In contrast, several previously published studies reported induction of antioxidant enzymes after consumption of green tea [Khan et al, 1992;Lin et al, 1998;Khan et al, 2007;Park et al, 2011]. However, all these studies were performed in non-obese individuals and with doses of green tea exceeding those used in our study.…”

Section: Discussioncontrasting

confidence: 65%

Effect of Green Tea Extract-Enriched Diets on Insulin and Leptin Levels, Oxidative Stress Parameters and Antioxidant Enzymes Activities in Obese Mice

Bártíková¹,

Boušová²,

Matoušková³

et al. 2017

Pol. J. Food Nutr. Sci.

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Key words: monosodium glutamate-induced obesity, catechins, oxidative stress, polyphenon 60Green tea and green tea extracts (GTE) are often incorporated into diet intended to weight reduction, although the information about their effi cacy in obese individuals is insuffi cient. The present study was designed to follow up the effect of defi ned and standardized GTE in mice with obesity induced by monosodium L-glutamate. Obese mice were fed with GTE-supplemented diet in three dosage regimens: 28-day and 3-day intake of 1 g GTE in 1 kg of diet and 28-day intake of 0.1 g GTE in 1 kg of diet. The information on body weight, food intake, oxidation stress parameters in blood and antioxidant enzymes activity in liver and small intestine was obtained. High doses of GTE decreased the specifi c activities of glutathione reductase and catalase and increased concentrations of malondialdehyde in blood. Specifi c activities of antioxidant enzymes in the liver and small intestine were not altered after GTE treatment except the decrease of NAD(P)H:quinone oxidoreductase activity. Our results showed that GTE did not affect average body weight and did not markedly improve antioxidant status in glutamate-induced obese mice. Moreover, intake of high doses of GTE made antioxidant defense in obese animals even worse.Unauthenticated Download Date | 5/12/18 3:35 AM

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Section: Discussioncontrasting

confidence: 65%

Effect of Green Tea Extract-Enriched Diets on Insulin and Leptin Levels, Oxidative Stress Parameters and Antioxidant Enzymes Activities in Obese Mice

Bártíková¹,

Boušová²,

Matoušková³

et al. 2017

Pol. J. Food Nutr. Sci.

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show abstract

“…Particularly, green tea extracts with antioxidant, anti-carcinogen, anti-inflammatory and anti-radiation properties have been a focus of recent scientific research. Beneficial effects of green tea or its extracts against cancer, obesity, metabolic syndrome and cardiovascular disease have been reported [11][12][13]. Antioxidant properties of green tea are associated with the presence of several polyphenols, primarily catechins including epigallocatechin gallate (EGCG), (-) epicatechin gallate (ECG), (-) epicatechin (EC) and (-) epigallocatechin (EGC) [14].…”

Section: Introductionmentioning

confidence: 99%

Blood serum DSC analysis of well-trained men response to CrossFit training and green tea extract supplementation

Michnik

Sadowska-Krępa

Domaszewski

et al. 2017

J Therm Anal Calorim

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Differential scanning calorimetry (DSC) has been used for the detection of post-exercise changes in blood serum resulting from participation in the CrossFit (CF) training combined with green tea extract (GTE) supplementation. Blood samples from 20 well-trained men were collected at rest, immediately post-exercise and after 1 h of recovery in two trials: first before and second after CF training combined with GTE or placebo administration in the supplemented (S) and control (C) groups, respectively. Selected muscle damage biomarkers have been compared in different phases of the experiment. A significant increase in blood lactate content has been observed post-exercise in both trials in both participants' groups. The opposite trends have been noted for the C and S groups in creatine kinase (CK) activity changes recorded during the first to the second trial: an increase in CK for the control and a decrease for the supplemented group in all phases of the experiment: pre-exercise, post-exercise and after recovery. In the second trial, all CK values for the S group have been found significantly lower than the corresponding values recorded in the C group. These results suggest a mitigate effect of GTE supplementation on post-training muscle damage. DSC results did not reveal clear effects of training nor GTE supplementation on serum denaturation transition. However, interesting dependences of thermodynamic parameters describing this transition have been observed in different phases of the experiment. Statistically significant negative correlations have been found between post-training VO 2max and post-exercise thermodynamic parameters associated with haptoglobin contribution to serum denaturation transition.

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“…Comparing to the one treated with nanogreen tea extract in the presence of CCl 4 and ethanol 22% and the zero in control. The total damaged are in control was found as 15.9% and in CCl 4 /ethanol group it was 44.7% and in CCl 4 / ethanol/Nano GTE was 21% [5,9,12,15].…”

Section: Discussionmentioning

confidence: 86%

A Quantitative Description of Lipid and Extracellular Matrix Proteinaceous Fibers in Hepatic Fibrosis of a Rat Model by ImageJ using Nano-Images

Safer¹

2017

J Nanomed Nanotechnol

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Green tea extract attenuates hepatic steatosis by decreasing adipose lipogenesis and enhancing hepatic antioxidant defenses in ob/ob mice

Cited by 143 publications

References 51 publications

Effect of Green Tea Extract-Enriched Diets on Insulin and Leptin Levels, Oxidative Stress Parameters and Antioxidant Enzymes Activities in Obese Mice

Effect of Green Tea Extract-Enriched Diets on Insulin and Leptin Levels, Oxidative Stress Parameters and Antioxidant Enzymes Activities in Obese Mice

Blood serum DSC analysis of well-trained men response to CrossFit training and green tea extract supplementation

A Quantitative Description of Lipid and Extracellular Matrix Proteinaceous Fibers in Hepatic Fibrosis of a Rat Model by ImageJ using Nano-Images

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