Effect of Green Tea Extract-Enriched Diets on Insulin and Leptin Levels, Oxidative Stress Parameters and Antioxidant Enzymes Activities in Obese Mice

Abstract

Key words: monosodium glutamate-induced obesity, catechins, oxidative stress, polyphenon 60Green tea and green tea extracts (GTE) are often incorporated into diet intended to weight reduction, although the information about their effi cacy in obese individuals is insuffi cient. The present study was designed to follow up the effect of defi ned and standardized GTE in mice with obesity induced by monosodium L-glutamate. Obese mice were fed with GTE-supplemented diet in three dosage regimens: 28-day and 3-day intake of 1 g GTE in 1 kg of diet and 28-day intake of 0.1 g GTE in 1 kg of diet. The information on body weight, food intake, oxidation stress parameters in blood and antioxidant enzymes activity in liver and small intestine was obtained. High doses of GTE decreased the specifi c activities of glutathione reductase and catalase and increased concentrations of malondialdehyde in blood. Specifi c activities of antioxidant enzymes in the liver and small intestine were not altered after GTE treatment except the decrease of NAD(P)H:quinone oxidoreductase activity. Our results showed that GTE did not affect average body weight and did not markedly improve antioxidant status in glutamate-induced obese mice. Moreover, intake of high doses of GTE made antioxidant defense in obese animals even worse.Unauthenticated Download Date | 5/12/18 3:35 AM

Diet-Induced Adipocyte Browning

“…Cacao and tea are the rich sources of (-)-epicatechin [Bártíková et al, 2017;Ramiro-Puig & Castell, 2009]. The bioavailability of this flavan-3-ol was described by urinary recovery ranging from 24.1 to 29.8%, 24 h after ingestion of cacao or chocolate, respectively, while the majority of (-)-epicatechin metabolites (80%) are eliminated in just 8 h [Baba et al, 2000].…”

Iron, Zinc, Copper, Manganese and Chromium in Green Teas, Their Transfer to Extracts and Correlations between Contents of Elements and Bioactive Compounds

“…They are also responsible for a wide range of other bioactivities including anti-inflammatory, antidiabetic and anticancer activities, antiobesity and immunoregulatory effects, as well as cardiovascular-and hepato-protective properties [Tang et al, 2019]. Therefore, there is a growing interest in not only infusions but also green tea extracts as a health-promoting component of the diet [Bártíková et al, 2017;Tang et al, 2019]. Green tea extracts are also increasingly applied, as a natural alternative to chemical antioxidants, in food technology to extend the shelf life of food products [Senanayake, 2013].…”