Green tea consumption is associated with reduced incident CHD and improved CHD-related biomarkers in the Dongfeng-Tongji cohort

Tian, Chong; Huang, Qiao; Yang, Liangle; Légaré, Sébastien; Angileri, Francesca; Yang, Handong; Li, Xiulou; Min, Xinwen; Zhang, Ce; Xu, Chengwei; Yuan, Jing; Miao, Xiaoping; He, Meian; Wu, Tangchun; Zhang, Xiaomin

doi:10.1038/srep24353

Cited by 34 publications

(31 citation statements)

References 41 publications

(54 reference statements)

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“…At the taxonomic level of genus, increased levels of SCFA‐producing Roseburia, Feacalibacterium, Eubacterium, Blautia, Coprococcus , and Dorea ( Figure A,B) were found with GTL. Also, elevated levels of Bifidobacterium and B/E ( Bifidobacterium to Enterobacteriacea ratio), which is a well‐established marker of colonization resistance (CR) against pathogenic bacteria, and decreased proinflammatory Fusobacterium genus (Figure A,B) were found with GTL. At the level of species, significantly elevated levels of uncultured (UCO) species from Roseburia , Faecalibacterium , Eubacterium rectale group , Blautia , Coprococcus , Dorea formicigenerans , Dorea longicatena , Clostridium scindens , and Bifidobacterium longum (Figure C,D) and lower levels of uncultured Prevotella 9 were associated with GTL (Figure C,D).…”

Section: Resultsmentioning

confidence: 99%

“…GT is characterized by the presence of large amounts of polyphenols, also known as catechins, such as epigallocatechin‐3‐gallate, epigallocatechin, epicatechin gallate, and epicatechin . Several health benefits have been claimed for GT extracts (GTE) and GT polyphenols (GTPs), including prevention of cardiovascular disease, metabolic syndrome (MS), and colorectal cancer (CRC), some of which are supported by evidence from randomized trials . At the same time, conflicting results have been reported from epidemiological studies regarding the pathogenic effects of GT …”

Section: Introductionmentioning

confidence: 99%

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Green Tea Liquid Consumption Alters the Human Intestinal and Oral Microbiome

Yuan

Long

et al. 2018

Molecular Nutrition Food Res

108

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ScopeGTPs (green tea polyphenols) exert anti‐CRC (colorectal cancer) activity. The intestinal microbiota and intestinal colonization by bacteria of oral origin has been implicated in colorectal carcinogenesis. GT modulates the composition of mouse gut microbiota harmonious with anticancer activity. Therefore, the effect of green tea liquid (GTL) consumption on the gut and oral microbiome is investigated in healthy volunteers (n = 12).Methods and results16S sequencing and phylogenetic investigation of communities by reconstruction of unobserved states (PICRUSt) analysis of both fecal and saliva samples (collected before intervention, after 2 weeks of GTL (400 mL per day) and after a washout period of one week) in healthy volunteers show changes in microbial diversity and core microbiota and difference in clear classification (partial least squares‐discriminant analysis [PLS‐DA]). An irreversible, increased FIR:BAC (Firmicutes to Bacteroidetes ratio), elevated SCFA producing genera, and reduction of bacterial LPS synthesis in feces are discovered in response to GTL. GTL alters the salivary microbiota and reduces the functional pathways abundance relevance to carcinogenesis. Similar bacterial networks in fecal and salivary microbiota datasets comprising putative oral bacteria are found and GTL reduces the fecal levels of Fusobacterium. Interestingly, both Lachnospiraceae and B/E (Bifidobacterium to Enterobacteriacea ratio—markers of colonization resistance [CR]) are negatively associated with the presence of oral‐like bacterial networks in the feces.ConclusionThese results suggest that GTL consumption causes both oral and gut microbiome alterations.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Green Tea Liquid Consumption Alters the Human Intestinal and Oral Microbiome

Yuan

Long

et al. 2018

Molecular Nutrition Food Res

108

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“…[6][7][8][9][10][11][12][13][14][15][16] Two studies 7 8 conducted in the Dutch population have shown that statistically significant protective effect of tea consumption, mainly black tea, on coronary heart disease (CHD) incidence were only observed for participants who drank tea >6 cups/day (HR 0.64, 95% CI0.46 to 0.90) 7 or for those who drank >375 mL/day (0.57, 0.33 to 0.98). 8 The Netherlands Cohort Study also observed an inverse association between an increment of 253 mL/day tea consumption and IHD mortality in men (HR 0.91, 95% CI 0.83 to 1.00).…”

Section: Discussionmentioning

confidence: 99%

Tea consumption and risk of ischaemic heart disease

Guo

et al. 2017

Heart

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ObjectiveTo prospectively examine the association between tea consumption and the risk of ischaemic heart disease (IHD).MethodsProspective study using the China Kadoorie Biobank; participants from 10 areas across China were enrolled during 2004–2008 and followed up until 31 December 2013. After excluding participants with cancer, heart disease and stroke at baseline, the present study included 199 293 men and 288 082 women aged 30–79 years at baseline. Information on IHD incidence was collected through disease registries and the new national health insurance databases.ResultsDuring a median follow-up of 7.2 years, we documented 24 665 (7.19 cases/1000 person-years) incident IHD cases and 3959 (1.13 cases/1000 person-years) major coronary events (MCEs). Tea consumption was associated with reduced risk of IHD and MCE. In the whole cohort, compared with participants who never consumed tea during the past 12 months, the multivariable-adjusted HRs and 95% CIs for less than daily and daily tea consumers were 0.97 (0.94 to 1.00) and 0.92 (0.88 to 0.95) for IHD, 0.92 (0.85 to 1.00) and 0.90 (0.82 to 0.99) for MCE. No linear trends in the HRs across the amount of tea were observed in daily consumers for IHD and MCE (PLinear >0.05). The inverse association between tea consumption and IHD was stronger in rural (PInteraction 0.006 for IHD, <0.001 for MCE), non-obese (PInteraction 0.012 for MCE) and non-diabetes participants (PInteraction 0.004 for IHD).ConclusionsIn this large prospective study, daily tea consumption was associated with a reduced risk of IHD.

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“…Various previous cohort studies have shown that high consumption of food components, such as whole grains40, fruits41, vegetables42, legumes (including beans)43, nuts44, and tea45 is associated with a reduced risk of CHD mortality. The food components confirmed in the previous studies are generally consistent with those identified in this study.…”

Section: Discussionmentioning

confidence: 99%

Plant-based foods containing cell wall polysaccharides rich in specific active monosaccharides protect against myocardial injury in rat myocardial infarction models

Lim

Kim

Yun

et al. 2016

Sci Rep

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Many cohort studies have shown that consumption of diets containing a higher composition of foods derived from plants reduces mortality from coronary heart disease (CHD). Here, we examined the active components of a plant-based diet and the underlying mechanisms that reduce the risk of CHD using three rat models and a quantitative proteomics approach. In a short-term myocardial infarction (MI) model, intake of wheat extract (WE), the representative cardioprotectant identified by screening approximately 4,000 samples, reduced myocardial injury by inhibiting apoptosis, enhancing ATP production, and maintaining protein homeostasis. In long-term post-MI models, this myocardial protection resulted in ameliorating adverse left-ventricular remodelling, which is a predictor of heart failure. Among the wheat components, arabinose and xylose were identified as active components responsible for the observed efficacy of WE, which was administered via ingestion and tail-vein injections. Finally, the food components of plant-based diets that contained cell wall polysaccharides rich in arabinose, xylose, and possibly fucose were found to confer protection against myocardial injury. These results show for the first time that specific monosaccharides found in the cell wall polysaccharides in plant-based diets can act as active ingredients that reduce CHD by inhibiting postocclusion steps, including MI and heart failure.

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Green tea consumption is associated with reduced incident CHD and improved CHD-related biomarkers in the Dongfeng-Tongji cohort

Cited by 34 publications

References 41 publications

Green Tea Liquid Consumption Alters the Human Intestinal and Oral Microbiome

Green Tea Liquid Consumption Alters the Human Intestinal and Oral Microbiome

Tea consumption and risk of ischaemic heart disease

Plant-based foods containing cell wall polysaccharides rich in specific active monosaccharides protect against myocardial injury in rat myocardial infarction models

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