Green synthesis of silver nanoparticles using methanol extract of Ipomoea carnea Jacq. to combat multidrug resistance bacterial pathogens

Singh, Ramveer; Bithel, Navneet

doi:10.1016/j.crgsc.2021.100152

Cited by 13 publications

(5 citation statements)

References 15 publications

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“…The FESEM analysis showed well dispersed bAgNPs at 0.5µm and most nanoparticles are with aggregated and spherical in shape. Green AgNPs synthesized from methanolic extracts of Ipomoea carnea shown spherical shaped and uniformly dispersed nanoparticles in FE SEM analysis (Singh, 2021) and gAgNPs synthesized from Pseudoduganella eburnean shown rod shaped and uniformly dispersed nanoparticles (Huq, 2020). In contrast FE SEM analysis of the present study reported the bAgNPs with Spherical and non-homogenous shapes and aggregated in form (Fig.…”

Section: Resultscontrasting

confidence: 55%

Synthesis of Biogenic Silver Nanoparticles (bAgNPs) Using Leaf Extract of Mirabilis jalapa and Evaluation of Anti-vibriocidal, Anti-oxidant properties and Cytotoxicity

et al. 2023

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Acute hepatopancreatic necrosis disease and luminescent vibriosis are two major bacterial diseases of penaeid shrimp which are caused by gram negative pathogenic bacteria Vibrio parahaemolyticus (Vp) and Vibrio harveyi (Vh) respectively. These diseases cause massive mortality and huge economic loss worldwide in shrimp aquaculture. Extensive and inappropriate usage of antibiotics against these pathogens resulted in antibiotic resistant strains. Drug repurposing appears to be an appropriate solution to eliminate the antibiotic resistance in pathogens. In the present study, biogenic silver nanoparticles (bAgNPs) are synthesized by reducing AgNO 3 using aqueous extract of Mirabilis jalapa (MJ) leaves. The anti-oxidant, cytotoxic and anti-vibriocidal activity of bAgNPs against Vp and Vh are evaluated. The formation of silver nanoparticles was con rmed by the appearance of dark brown colored solution and with a maximum absorption peak at 434nm. The characterization of bAgNPs using FESEM, TEM, XRD, FTIR, and DLS has con rmed that the nanoparticles are crystalline, spherical in shape with an approximate diameter of 50nm, and have capping agents. The diameter of microbial growth inhibition zones for Vp and Vh are 26mm and 23mm respectively. Further, the MIC values for Vp and Vh are 31.25µg/mL and 93.75µg/mL respectively. The DPPH and FRAP assays showed substantial anti-oxidant activity with IC 50 values of 67.39µg/mL and 5.509µg/mL respectively. MTT assay to check cytotoxicity effect of bAgNPs on Vero cells resulted very less toxicity at maximum concentration tested with an IC 50 value of 293.5µg/mL. Therefore, the biogenic silver nanoparticles synthesized from leaves of MJ showed effective anti-vibriocidal and anti-oxidant properties with negligible cytotoxic effect.

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Section: Resultscontrasting

confidence: 55%

Synthesis of Biogenic Silver Nanoparticles (bAgNPs) Using Leaf Extract of Mirabilis jalapa and Evaluation of Anti-vibriocidal, Anti-oxidant properties and Cytotoxicity

et al. 2023

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“…Many medicinal plants such as Berberis vulgaris (Deepak et al, 2020), Ipomoea carnea Jacq. (Singh and Navneet, 2021), Tectona grandis (Rautela et al, 2019), Azadirachta indica (Ahmed et al, 2016), Salvia spinosa (Pirtarighat et al, 2018), and Astragalus tribuloides Delile (Sharifi-Rad et al, 2020) have been explored for the Phyto-fabrication of AgNPs. Silver must be in its ionized form for it to have any antibacterial properties.…”

Section: Introductionmentioning

confidence: 99%

Environmentally benign silver bio-nanomaterials as potent antioxidant, antibacterial, and antidiabetic agents: Green synthesis using Salacia oblonga root extract

Dugganaboyana

Mukunda²,

Jain³

et al. 2023

Front. Chem.

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Introduction: The use of plant extracts in the green synthesis of metallic nanoparticles is one of the simplest, most practical, economical, and ecologically friendly methods for avoiding the use of toxic chemicals.Method: Silver nanoparticles (AgNPs) were synthesized, employing a high-efficiency, non- toxic, cost-effective, green, and simple technique that included the use of Salacia oblonga root extract (SOR) as a capping agent compared to synthetic nanoparticles. The use of S. oblonga can be seen in traditional medicines for treating diabetes, obesity, rheumatism, gonorrhea, asthma, and hyperglycemia. The objectives of the current study were to green synthesize S. oblonga root extract silver nanoparticles (SOR-AgNPs), characterize them, and study their antioxidant, antibacterial, and antidiabetic activities.Result: The shape of SOR-AgNPs was spherical, at less than 99.8 nm in size, and exhibited a crystalline peak at XRD. The green synthesized SOR-AgNPs showed significant antioxidant properties like DPPH (80.64 μg/mL), reducing power capacity (81.09 ± SEM μg/mL), nitric oxide (96.58 μg/mL), and hydroxyl (58.38 μg/mL) radical scavenging activities. The MIC of SOR-AgNPs was lower in gram-positive bacteria. The SOR-AgNPs have displayed efficient inhibitory activity against α-amylase, with an EC50 of 58.38 μg/mL. Analysis of capping protein around the SOR-AgNPs showed a molecular weight of 30 kDa.Discussion: These SOR-AgNPs could be used as antibacterial and antidiabetic drugs in the future as it is cheap, non-toxic, and environmentally friendly. Bio-fabricated AgNPs had a significant impact on bacterial strains and could be used as a starting point for future antibacterial drug development.

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“…In our study, AgNPs were found to be moderately toxic, where the LC 50 for control DS-AgNPs was reported to be 21. 88 found that AgNPs synthesized using the extract of Ipomoea carnea were non-toxic towards brine shrimps; however, their toxicity increased in a concentration-dependent manner. Given that the toxicity of the smaller-sized Y-DS-AgNPs tended more towards mild toxicity, they can be used as commercial anticancerous agents given that they were the most cytotoxic, while being safe on the environment and living organisms.…”

Section: Biocompatibility Of Agnpsmentioning

confidence: 99%

Light-emitting diode (LED)-directed green synthesis of silver nanoparticles and evaluation of their multifaceted clinical and biological activities

et al. 2022

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Green synthesis of silver nanoparticles using methanol extract of Ipomoea carnea Jacq. to combat multidrug resistance bacterial pathogens

Cited by 13 publications

References 15 publications

Synthesis of Biogenic Silver Nanoparticles (bAgNPs) Using Leaf Extract of Mirabilis jalapa and Evaluation of Anti-vibriocidal, Anti-oxidant properties and Cytotoxicity

Synthesis of Biogenic Silver Nanoparticles (bAgNPs) Using Leaf Extract of Mirabilis jalapa and Evaluation of Anti-vibriocidal, Anti-oxidant properties and Cytotoxicity

Environmentally benign silver bio-nanomaterials as potent antioxidant, antibacterial, and antidiabetic agents: Green synthesis using Salacia oblonga root extract

Light-emitting diode (LED)-directed green synthesis of silver nanoparticles and evaluation of their multifaceted clinical and biological activities

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