Introduction: The use of plant extracts in the green synthesis of metallic nanoparticles is one of the simplest, most practical, economical, and ecologically friendly methods for avoiding the use of toxic chemicals.Method: Silver nanoparticles (AgNPs) were synthesized, employing a high-efficiency, non- toxic, cost-effective, green, and simple technique that included the use of Salacia oblonga root extract (SOR) as a capping agent compared to synthetic nanoparticles. The use of S. oblonga can be seen in traditional medicines for treating diabetes, obesity, rheumatism, gonorrhea, asthma, and hyperglycemia. The objectives of the current study were to green synthesize S. oblonga root extract silver nanoparticles (SOR-AgNPs), characterize them, and study their antioxidant, antibacterial, and antidiabetic activities.Result: The shape of SOR-AgNPs was spherical, at less than 99.8 nm in size, and exhibited a crystalline peak at XRD. The green synthesized SOR-AgNPs showed significant antioxidant properties like DPPH (80.64 μg/mL), reducing power capacity (81.09 ± SEM μg/mL), nitric oxide (96.58 μg/mL), and hydroxyl (58.38 μg/mL) radical scavenging activities. The MIC of SOR-AgNPs was lower in gram-positive bacteria. The SOR-AgNPs have displayed efficient inhibitory activity against α-amylase, with an EC50 of 58.38 μg/mL. Analysis of capping protein around the SOR-AgNPs showed a molecular weight of 30 kDa.Discussion: These SOR-AgNPs could be used as antibacterial and antidiabetic drugs in the future as it is cheap, non-toxic, and environmentally friendly. Bio-fabricated AgNPs had a significant impact on bacterial strains and could be used as a starting point for future antibacterial drug development.
Here, we explored the medicinal uses of the novel biogenic silver nanoparticles of Eugenia uniflora L. (E. uniflora) seed extract as a cost effective, eco-friendly, reducing and stabilizing compounds. This study describes the synthesis of silver nanoparticles from Eugenia uniflora L. (E. uniflora) seed extract and their antioxidant, antibacterial and cytotoxic potential. Biosynthesis of AgNPs was monitored by UV-visible spectroscopy which revealed intense surface plasmon resonance bands at 447 nm and X-ray diffraction were employed to identify various functional groups and crystalline nature of AgNPs. Scanning electron microscopy studies demonstrated that synthesized particles were crystalline in nature with average size of 78-100nm. In vitro antioxidant effects were analyzed by butylated hydroxytoluene (BHT)) and 2,2-diphenyl-1-picrylhydrazyl (DPPH), which exhibited antioxidant activity there in the particles could scavenges the stable free radical DPPH of 75% to that o positive control BHT. The value of 50% inhibition concentration (IC50) of Standard BHT is 65.55 and E. uniflora is 38.63µg/ml. The antibacterial activity of green AgNPs displayed better zone of inhibition against selected human pathogens. The present study also investigated the toxicity effect of biogenic AgNPs against human prostate cancer cells (PC-3) and the inhibitory concentrations (IC50) were found to be 6.25μg/ml, respectively. It could be concluded that E. uniflora seed extract AgNPs can be used efficiently for potential antioxidant, antibacterial and cytotoxic potential AgNPs with potent biomedical applications.
Plant based synthesis of nanoparticles has generated worldwide interest because of cost-effectiveness, eco-friendly nature and abundance of applications. In the present investigation , antimicrobial potential of silver nanoparticles (AgNPs) of aqueous extract of Tabebuia rosea (Bertol.) DC (T. rosea) fruit extract has been investigated. Agar disc diffusion method was used for determining the antimicrobial activity of selected aqueous fruit extract AgNPs. Phytochemical analysis of aqueous fruit extract of T. rosea fruit revealed the presence of alkaloids, flavonoids, tannins, phenols, carbohydrates, glycosides, Vitamin-C, proteins and terpenoids. AgNPs synthesis using T. rosea aqueous fruit extract and characterized by UV-Visible spectroscopy showed a peak at 420 nm and average size of 82.9 nm, FT-IR analysis, dynamic light scattering, scanning electron microscope, EDX and X-ray diffraction analysis. Evaluation of antibacterial activity of green synthesized AgNPs recorded the more potent activity against selected human bacterial pathogens. The results obtained indicated that the fruit extract of T. rosea as well as AgNPs have strong and effective antibacterial potential that provide marvelous source for the development of new drug molecules of herbal origin which may be used for the welfare of humanity.
In recent years, green nanotechnology-based approaches using plant materials have been accepted as an environmentally friendly and cost-effective approach with various biomedical applications. In the current study, AgNPs were synthesized using the seed extract of the Eugenia uniflora L. (E.uniflora). Characterization was done using UV-Visible spectroscopy, X-ray diffraction (XRD), scanning electronic microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDX) analyses. The formation of AgNPs has confirmed through UV-Visible spectroscopy (at 466 nm) by the change of color owing to surface Plasmon resonance. Based on the XRD pattern, the crystalline property of AgNPs was established. The functional group existing in seed of E.uniflora extract accountable for the reduction of Ag+ ion and the stabilization of AgNPs was investigated. The morphological structures and elemental composition was determined by SEM and EDX analysis. With the growing application of AgNPs in biomedical perspectives, the biosynthesized AgNPs were evaluated for their antibacterial and along with their antidiabetic potential. The results showed that AgNPs are extremely effective with potent antidiabetic potential at a very low concentration. It also exhibited potential antibacterial activity against the three tested human pathogenic bacteria. Overall, the results highlight the effectiveness and potential applications of AgNPs in biomedical fields such as in the treatment of acute illnesses as well as in drug formulation for treating various diseases such as cancer and diabetes. It could be concluded that E. uniflora seed extract AgNPs can be used efficiently for in vitro evaluation of their antibacterial and antidiabetic effects with potent biomedical applications.
The green synthesis of nanoparticles has emerged as a cost-effective and environmentally benign technique for therapeutic applications. Nanomedicine utilizes biocompatible nanomaterials for diagnostic and therapeutic potential for various biomedical applications. Different biological methods are gaining recognition over the physical and chemical methods of synthesis for the production of silver nanoparticles (AgNPs) due to their multiple applications. The present study describes the synthesis of AgNPs using the fruit extract of Simaroubaamara (S. amara)followed by characterization of AgNPswas done using different methods, which include; ultraviolet-visible spectroscopy (UV-Vis) wherein it shows absorption peak at 410 nm confirming the AgNPs, from dynamic light scattering (DLS) the average particle size is 80nm with crystalline structure confirmed by scanning electron microscope (SEM) images and zeta potential analysis shows the positive polarity of the particle favoring the drug targeting. The powder X-ray diffraction study (PXRD) revealed crystalline nature with a face-centered cubic (fcc) structure of AgNPs. The synthesized AgNPs were also tested for antioxidant therein the particles could scavenge the stable free radical 1, 1-Diphenyl-2-picrylhydrazyl (DPPH) of about 80% to that of positive control butylated hydroxytoluene (BHT) and antimicrobial studies indicated its microbicidal efficacy against both Gram positive and negative clinical pathogens. It could be concluded that Simaroubaamara fruit extract can be used efficiently in the production of potential antioxidant and antimicrobial AgNPs for commercial application.
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