Green synthesis of mono- and di-selenium-N-heterocyclic carbene adducts: Characterizations, crystal structures and pro-apoptotic activities against human colorectal cancer

Iqbal, Muhammad Adnan; Haque, Rosenani A.; Ng, Woen C.; Hassan, Loiy E.H.; Majid, Amin Malik Shah Abdul; Razali, Mohd. R.

doi:10.1016/j.jorganchem.2015.10.023

Cited by 27 publications

(18 citation statements)

References 39 publications

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“…Interestingly, a L 59 showed a comparable IC 50 value (4.73 μg/ml) to C 59 (3.98 μg/ml) which is a rarely occurred and unexplanable phenomenon . It has been observed that metal complexes almost always show an enhanced anticancer properties compared to parent ligands …”

Section: Mn–complexes With Mixed Ligandsmentioning

confidence: 99%

Coordination Complexes of Manganese and Their Biomedical Applications

Ali

Iqbal

2017

ChemistrySelect

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The clinical success of metallodrugs is rapidly increasing. The historical use of cisplatin and recently a successful marketing of its clinically advanced derivatives (oxaliplatin, carboplatin, nedaplatin, lobaplatin and heptaplatin) for the treatment of various types of cancer has opened new horizons for metal based drugs. Complexes of cobalt, gold, ruthenium, palladium, manganese and even arsenic are either being marketed or close to get success in clinical trials for the treatment of various diseases. Current review compiles the advances on manganese complexes and their biomedical applications. A possible structure activity relationship has been discussed.

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Section: Mn–complexes With Mixed Ligandsmentioning

confidence: 99%

Coordination Complexes of Manganese and Their Biomedical Applications

Ali

Iqbal

2017

ChemistrySelect

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“…Bisbenzimidazolium salts (2 and 4) synthesized by their respective N-alkylation of benzimidazole. Selenium N-Heterocyclic carbene adducts (5 and 6) were synthesized by In-situ approach according to reported procedures as shown in Scheme-I [8,10]. Melting points of synthesized compounds by Stuart Melting Point method SMP11.…”

Section: Synthesis Of Designed Analoguesmentioning

confidence: 99%

“…The hot reaction mixture was passed through the ltration apparatus, the insoluble mass (crudeproduct) retained on lter paper which was washed with fresh hot water several times so as to remove all of unreacted ligand and alkali molecules. When all of water was evaporated from product-contain ltration apparatus, fresh DMSO was poured so as to solubilize and pass the pure selenium adduct from lter paper to ask [8].…”

Section: Synthesis Of Binuclear Se-n-heterocyclic Carbene (Se-nhc) Compoundsmentioning

confidence: 99%

“…A better modulation-approach implies its coordination with N-Heterocyclic carbene analogues which can endow a potential permeability over a wide range of lipophilicity to better cross membrane barriers [7]. In this way, it becomes capable to show chemo-preventive activities like antioxidant, anti-depressant, antineoplastic anti-in ammatory, anti-neuro-degenerative, antimicrobial and anti-viral activities [8,9]. Initially, mononuclear selenium N-Heterocyclic carbenes analogues were synthesized and tested in this pursuit.…”

Section: Introductionmentioning

confidence: 99%

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Docking-designed Green Synthesis and In-Vitro Anticancer Studies of New Binuclear Se-N-Heterocyclic Carbene Adducts and their Azolium Salts

Atif

Nazari

Ahamed³

et al. 2021

Preprint

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Two binuclear selenium adducts (5 and 6) were designed using molecular docking approach while finding their promising interaction to four angiogenic factor-proteins including COX-1 (Cyclooxygenase-1), VEGF-A (vascular endothelial growth factor A), HIF (Hypoxia-inducible factor) and EGF (human epidermal growth factor). They were consequently synthesized using In-situ coordination approach. The green synthetic approach was employed for coordination as it was carried out in water instead of organic solvents. The synthesized adducts as well as their respective bis-benzimidazolium salts (2 and 4) were confirmed by 1H and 13C-NMR along with FT-IR spectroscopy. The both were, then, subjected to In-vitro anticancer activities against breast adenocarcinoma cell line (MCF-7), cervical cancer cell line (Hela), mouse melanoma cell line (B16F10) and retinal ganglion cell line (RGC-5) using MTT assay while comparing their activities with a commercially established standard-drug 5-Fluorouracil. However, the exceptional activities of both adducts and bis-benzimidazolium salts were explored.

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“…Heterocyclic compounds including an imidazole or benzimidazole nucleus have shown different types of biological activity such as antimicrobial, antifungal, anthelmintic, anti‐allergic, antihistamine, analgesic, antineoplastic, anti‐inflammatory, hypotensive, vasodilator, antipyretic, and antinematodal . They also exhibit cytotoxic effects against various cancerous cells including the brain, pancreas, leukemia, ovaries, cervix, lymphocyte, prostate, colon, breast, lung, liver, bone marrow, and peripheral blood . Due to their anticancer activity, many research groups have been involved in developing new heterocyclic compounds.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and In Vitro Anticancer Evaluation of Some Benzimidazolium Salts

Akkoç

Kayser

2019

Journal of Heterocyclic Chem

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A series of benzimidazolium salts having 2‐cyanobenzyl (2–6), 2‐(4‐nitrophenyl)ethyl (7–10), (1,3‐dioxoisoindolin‐2‐yl)butyl (11–17) or N‐methylphthalimide (18–22) substitution were synthesized and characterized by spectroscopic and analytical techniques. The in vitro cytotoxic activity of these salts was tested against human colon cancer (DLD‐1), human breast cancer (MDA‐MB‐231), and normal human noncancerous embryonic kidney (HEK‐293T) cell lines using the MTT assay method. The viability rates of the cells were determined by confocal microscopy. The majority of the newly synthesized compounds, with the exception of compounds 2, 3, 8, 11, 12, and 17, displayed high cytotoxic activity against cancerous cells. In fact, compounds 6 and 7 exhibited better results than the positive control drugs, cisplatin and busulfan, against the MDA‐MB‐231 cells. Therefore, compounds 6 and 7 could be considered as anticancer drug candidates for further development.

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Green synthesis of mono- and di-selenium-N-heterocyclic carbene adducts: Characterizations, crystal structures and pro-apoptotic activities against human colorectal cancer

Cited by 27 publications

References 39 publications

Coordination Complexes of Manganese and Their Biomedical Applications

Coordination Complexes of Manganese and Their Biomedical Applications

Docking-designed Green Synthesis and In-Vitro Anticancer Studies of New Binuclear Se-N-Heterocyclic Carbene Adducts and their Azolium Salts

Synthesis and In Vitro Anticancer Evaluation of Some Benzimidazolium Salts

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