Green synthesis of Copper oxide nanoparticles decorated with graphene oxide for anticancer activity and catalytic applications

Ganesan, K.; Jothi, Vinoth Kumar; Abirami, N.; Arulmozhi, R.; Ravichandran, Siranjeevi; Ramalingam, Satish

doi:10.1016/j.arabjc.2020.06.033

Cited by 147 publications

(34 citation statements)

References 87 publications

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“…The cells were incubated for 3 h. and absorbance was calculated at 595 nm wavelength in a microtiter plate reader (Bio-Rad, USA). Compared to untreated and control cells, the net cell viability has been determined using the % absorption of the treated cells [ 22 ].…”

Section: Methodsmentioning

confidence: 99%

Wet chemical development of CuO/GO nanocomposites: its augmented antimicrobial, antioxidant, and anticancerous activity

Biswas

Mohanta

Mishra

et al. 2021

J Mater Sci: Mater Med

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This study employed a bottom-up technique to synthesize copper oxide (CuO) nanoparticles over hydrophilic graphene oxide (GO) nanosheets. The CuO/GO nanocomposite has been prepared using two selected precursors of copper nitrate and citric acid with an intermittent mixing of GO solutions. The synthesized Nanocomposites were characterized using different biophysical techniques like FT-IR, NMR, FE-SEM, and HR-TEM analyses. FT-IR analyses confirm the nanocomposites’ successful formation, which is evident from the functional groups of C=C, C-O, and Cu-C stretching vibrations. Morphological analyses reveal the depositions of CuO nanoparticles over the planar rough GO sheets, which has been elucidated from the FE-SEM and HR-TEM analyses supported by respective EDAX analyses. The antimicrobial activities have been evident from the surface roughness and damages seen from the FE-SEM analyses. The CuO/GO sheets were tested against Gram-positive (e.g., Staphylococcus aureus) and Gram-negative (Escherichia coli, Pseudomonas aeruginosa). It is evident that the intrinsic antibacterial activity of CuO/GO sheets, when combined in equal proportions, elicited a robust antibacterial activity when tested over Gram –ve representative bacteria Escherichia coli. The antioxidant behaviour of synthesized CuO/GO nanocomposite was evaluated by scavenging the free radicals of DPPH and ABTS. Moreover, the cytotoxic activity was also studied against epidermoid carcinoma cell line A-431. A brief mathematical formulation has been proposed in this study to uncover the possibilities of using the nanocomposites as potential drug candidates in theranostic applications in disease treatment and diagnosis. This study would help uncover the electronic properties that play in the nano-scaled system at the material-bio interface, which would aid in designing a sensitive nano-electromechanical device bearing both the therapeutic and diagnostic attributes heralding a new horizon in the health care systems.

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Section: Methodsmentioning

confidence: 99%

Wet chemical development of CuO/GO nanocomposites: its augmented antimicrobial, antioxidant, and anticancerous activity

Biswas

Mohanta

Mishra

et al. 2021

J Mater Sci: Mater Med

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“… 142 Besides, green‐synthesized copper oxide (CuO) nanoparticles were decorated on GO nanoplatforms to perform against HCT‐116 human colon cancer cell lines (the cytotoxicity was ∼70%). 143 …”

Section: Important Challenges and Future Perspectivesmentioning

confidence: 99%

Graphene and graphene oxide with anticancer applications: Challenges and future perspectives

Shafiee

Iravani

Varma

2022

MedComm

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Graphene‐based materials have shown immense pertinence for sensing/imaging, gene/drug delivery, cancer therapy/diagnosis, and tissue engineering/regenerative medicine. Indeed, the large surface area, ease of functionalization, high drug loading capacity, and reactive oxygen species induction potentials have rendered graphene‐ (G‐) and graphene oxide (GO)‐based (nano)structures promising candidates for cancer therapy applications. Various techniques namely liquid‐phase exfoliation, Hummer's method, chemical vapor deposition, chemically reduced GO, mechanical cleavage of graphite, arc discharge of graphite, and thermal fusion have been deployed for the production of G‐based materials. Additionally, important criteria such as biocompatibility, bio‐toxicity, dispersibility, immunological compatibility, and inflammatory reactions of G‐based structures need to be systematically assessed for additional clinical and biomedical appliances. Furthermore, surface properties (e.g., lateral dimension, charge, corona influence, surface structure, and oxygen content), concentration, detection strategies, and cell types are vital for anticancer activities of these structures. Notably, the efficient accumulation of anticancer drugs in tumor targets/tissues, controlled cellular uptake properties, tumor‐targeted drug release behavior, and selective toxicity toward the cells are crucial criteria that need to be met for developing future anticancer G‐based nanosystems. Herein, important challenges and future perspectives of cancer therapy using G‐ and GO‐based nanosystems have been highlighted, and the recent advancements are deliberated.

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“…Furthermore, the peak appeared below 600 cm À1 is attributed to Cu-O vibrations; this clearly indicates successful bonding with copper atoms on the surface of tannic acid. 28,29 The -OH frequency reduction from 3500 cm À1 to 3172 cm À1 gives clear evidence that tannic acid will form a complex with copper metal ions. The above results indicate the presence of numerous -C]C and phenolic groups on the surface of NMc-CuTA along with covalently bonded copper metal ions.…”

Section: Characterizationmentioning

confidence: 99%

A Turn-ON fluorometric biosensor based on ssDNA immobilized with a metal phenolic nanomaterial for the sequential detection of Pb(ii) and epirubicin cancer drug

et al. 2021

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Green synthesis of Copper oxide nanoparticles decorated with graphene oxide for anticancer activity and catalytic applications

Cited by 147 publications

References 87 publications

Wet chemical development of CuO/GO nanocomposites: its augmented antimicrobial, antioxidant, and anticancerous activity

Wet chemical development of CuO/GO nanocomposites: its augmented antimicrobial, antioxidant, and anticancerous activity

Graphene and graphene oxide with anticancer applications: Challenges and future perspectives

A Turn-ON fluorometric biosensor based on ssDNA immobilized with a metal phenolic nanomaterial for the sequential detection of Pb(ii) and epirubicin cancer drug

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