Green Synthesis of CeO2 Nanoparticles from the Abelmoschus esculentus Extract: Evaluation of Antioxidant, Anticancer, Antibacterial, and Wound-Healing Activities

Abstract

Metal oxide nanoparticles synthesized by the biological method represent the most recent research in nanotechnology. This study reports the rapid and ecofriendly approach for the synthesis of CeO2 nanoparticles mediated using the Abelmoschus esculentus extract. The medicinal plant extract acts as both a reducing and stabilizing agent. The characterization of CeO2 NPs was performed by scanning electron microscopy (SEM), X-ray diffraction (XRD), ultraviolet-visible spectroscopy (UV-Vis), and Fourier transform infrared spectroscopy (FTIR). The in vitro cytotoxicity of green synthesized CeO2 was assessed against cervical cancerous cells (HeLa). The exposure of CeO2 to HeLa cells at 10–125 µg/mL caused a loss in cellular viability against cervical cancerous cells in a dose-dependent manner. The antibacterial activity of the CeO2 was assessed against S. aureus and K. pneumonia. A significant improvement in wound-healing progression was observed when cerium oxide nanoparticles were incorporated into the chitosan hydrogel membrane as a wound dressing.

Multifunctional mesoporous silica-cerium oxide nanozymes facilitate miR129 delivery for high-quality healing of radiation-induced skin injury

“…At a low of CeO 2 -NP concentration (25 µg/ml), cells begin to shrink and, similarly, with increasing concentration (75 µg/ml), there are further changes in cell morphology suggestive of apoptosis. At a concentration of 100 µg/ml, cancer cells exhibit increased apoptosis[ 10 ].…”

“…This might have been related to the fact that miR129 has not been reported to exhibit antibacterial activity, but CeO 2 has been reported to have good antibacterial activity. A study by Ahmed [ 10 ] study has shown that the antibacterial efficacy of CeO 2 -NPs against sea anemones largely depends on the NP concentration. As the concentration increases, the inhibition range also increases.…”

“…Cerium(IV) oxide nanoparticles (CeO 2 -NPs) have gained considerable attention in nanomedicine due to their promising applications in drug delivery, catalysis, biosensing, and medicine. These nanoparticles are relatively stable with special biocompatibility, little toxicity, low cost, and environmental friendliness [ 10 ]. Ce has two main oxidation states, including tetravalent (Ce 4+ ) and trivalent (Ce 3+ ) and thus ceria exists in the form of two oxides, namely Ce 2 O 3 and CeO 2 , depending on the nature of the material.…”

A Review on Green-Synthesis of Cerium Oxide Nanoparticles: Focus on Central Nervous System Disorders

“…As an antimicrobial and treatment for many disorders, CeO2NPs have been used. When it comes to the treatment of osteosarcoma and other bone cancers, CeO2NPs have been most often employed [69]. Because of their low toxicity and capacity to induce cancer cells to apoptosis or necrosis, these nanoparticles could be used as an effective treatment for cancer-antioxidant activity in CeO2NPs obtained from Origanum majorana as well as Ceratonia siliqua [70].…”

Dual Spinneret Electrospun Polyurethane/PVA-Gelatin Nanofibrous Scaffolds Containing Cinnamon Essential Oil and Nanoceria for Chronic Diabetic Wound Healing: Preparation, Physicochemical Characterization and In-Vitro Evaluation

“…The study plan uses a series of composite nanofibrous scaffolds composed of PU/PVA-Gel incorporated with CEO to potentiate the cell proliferation of NFs loaded with a low dose of nanoceria (nCeO 2 ). Nanoceria at 1–2% was reported for its efficiency as a cell proliferative agent used for tissue regeneration [ 41 , 42 , 43 ]. Below this concentration, the efficiency of nCeO 2 as a proliferative agent is reduced.…”