Green synthesis and characterization of silver nanoparticles using belladonna mother tincture and its efficacy as a potential antibacterial and anti-inflammatory agent
“…21 Several recent studies highlighted the role of different classes of plant secondary metabolites such as terpenoids, phenols, and alkaloids in the bio-reduction of silver salts. [22][23][24] The production of these metabolites can be streamlined in cell cultures using appropriate in vitro culture conditions and media composition including variation in supplemented phytohormones. 21 Alterations of growth regulators i.e.…”
We compared surface properties, metabolic capping and antibacterial activity of biosynthesized silver nanoparticles, synthesized through extracts of cell cultures of Fagonia indica and its naturally grown form.
“…21 Several recent studies highlighted the role of different classes of plant secondary metabolites such as terpenoids, phenols, and alkaloids in the bio-reduction of silver salts. [22][23][24] The production of these metabolites can be streamlined in cell cultures using appropriate in vitro culture conditions and media composition including variation in supplemented phytohormones. 21 Alterations of growth regulators i.e.…”
We compared surface properties, metabolic capping and antibacterial activity of biosynthesized silver nanoparticles, synthesized through extracts of cell cultures of Fagonia indica and its naturally grown form.
Silver nanoparticles (AgNPs) represent one of the most explored categories of nanomaterials for new and improved biomaterials and biotechnologies, with impressive use in the pharmaceutical and cosmetic industry, anti-infective therapy and wound care, food and the textile industry. Their extensive and versatile applicability relies on the genuine and easy-tunable properties of nanosilver, including remarkable physicochemical behavior, exceptional antimicrobial efficiency, anti-inflammatory action and antitumor activity. Besides commercially available and clinically safe AgNPs-based products, a substantial number of recent studies assessed the applicability of nanosilver as therapeutic agents in augmented and alternative strategies for cancer therapy, sensing and diagnosis platforms, restorative and regenerative biomaterials. Given the beneficial interactions of AgNPs with living structures and their nontoxic effects on healthy human cells, they represent an accurate candidate for various biomedical products. In the present review, the most important and recent applications of AgNPs in biomedical products and biomedicine are considered.
“…By capping silver nanoparticles with molecules such as belladonna, Das et al proposed a system with a higher in vitro anti-inflammatory response than diclofenac, a powerful anti-inflammatory drug. [57] This type of synthesis and the use of natural reagents allow to increase the biocompatibility of nanomaterials while controlling their size and the shape.…”
Implants and prostheses are widely used to replace damaged tissues or to treat various diseases. However, besides the risk of bacterial or fungal infection, an inflammatory response usually occurs. Here, recent progress in the field of anti‐inflammatory biomaterials is described. Different materials and approaches are used to decrease the inflammatory response, including hydrogels, nanoparticles, implant surface coating by polymers, and a variety of systems for anti‐inflammatory drug delivery. Complex multifunctional systems dealing with inflammation, microbial infection, bone regeneration, or angiogenesis are also described. New promising stimuli‐responsive systems, such as pH‐ and temperature‐responsive materials, are also being developed that would enable an “intelligent” antiinflammatory response when the inflammation occurs. Together, different approaches hold promise for creation of novel multifunctional smart materials allowing better implant integration and tissue regeneration.
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