Green and Sustainable Self-Assembly Nanocomposite from Gentamicin Sulfate/Lignosulfonate with Efficient Antibacterial and Wound-Healing Activity

Zou, Jiafeng; Bao, Dandan; Ma, Rui; Zhu, Zhihong; Chen, Xiaojie; Zhu, Jingjing; Fan, Xudong; Zhang, Ke; Zheng, Hua; Li, Fanzhu; Piao, Ji-Gang

doi:10.1021/acssuschemeng.0c00611

Cited by 25 publications

(14 citation statements)

References 55 publications

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“…The mice were anesthetized by Ketamin HCl injection (10 mg/kg), injected into the lower abdomen to make them unconscious for about 15 min. An electric trimmer was used to shave the dorsal fur 5 mm away from the ears of the mice and a wound approximately 1 cm × 1 cm was cut [ 17 ] in each mouse. For creating a full thickness wound with minimal bleeding, both the epidermal and dermal layers were removed.…”

Section: Methodsmentioning

confidence: 99%

Advanced CNC/PEG/PDMAA Semi-IPN Hydrogel for Drug Delivery Management in Wound Healing

Afrin

Shahruzzaman

Haque

et al. 2022

Gels

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A Semi Interpenetrating Polymer Network (semi-IPN) hydrogel was prepared and loaded with an antibiotic drug, gentamicin, to investigate the wound healing activity of this system. The semi-IPN hydrogel was synthesized by combining natural polymer cellulose nanocrystal (CNC) and synthetic polymer polyethylene glycol (PEG) and poly (N,N′-dimethyl acrylamide) (PDMAA), which was initially added as a monomer dimethyl acrylamide (DMAA). CNC was prepared from locally obtained jute fibers, dispersed in a PEG-NaOH solvent system and then mixed with monomer DMAA, where polymerization was initiated by an initiator potassium persulphate (KPS) and cross-linked by N,N′-methylenebisacrylamide (NMBA). The size, morphology, biocompatibility, antimicrobial activity, thermal and swelling properties of the hydrogel were investigated by different characterization techniques. The biocompatibility of the hydrogel was confirmed by cytotoxicity analysis, which showed >95% survival of the BHK-21, Vero cell line. The drug loaded hydrogel showed antimicrobial property by forming 25 and 23 mm zone of inhibition against Staphylococcus aureus (gram-positive) and Escherichia coli (gram-negative) bacteria, respectively, in antimicrobial analysis. At pH 5.5, 76% of the drug was released from the hydrogel within 72 h, as observed in an in vitro drug release profile. In an in vivo test, the healing efficiency of the drug loaded hydrogel was examined on a mice model with dorsal wounds. Complete healing of the wound without any scar formation was achieved in 12 days, which revealed excellent wound healing properties of the prepared drug loaded semi-IPN hydrogel. These results showed the relevance of such a system in the rapid healing of acute wounds.

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Section: Methodsmentioning

confidence: 99%

Advanced CNC/PEG/PDMAA Semi-IPN Hydrogel for Drug Delivery Management in Wound Healing

Afrin

Shahruzzaman

Haque

et al. 2022

Gels

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“…LS shows the ability to increase the growth of bacteria with structural damage, which may be according to the sugar of LS absorbed by bacteria. 112 LS can be used as an ecofriendly carrier that embraces potential in the synthesis of nanocomposites for antibacterial treatment. In a study by Zou et al, LS and gentamicin sulfate (GS) have been used to prepare a nanocomposite (LS-GS) with highly uniform size and good capacity of GS loading, excellent antibacterial activity, highly efficient antibacterial, and in vivo wound healing (Figure 7A).…”

Section: Green Chemistry In Skin Tissue Engineeringmentioning

confidence: 99%

Green Polymer Nanocomposites for Skin Tissue Engineering

Shokrani

Jouyandeh

et al. 2022

ACS Appl. Bio Mater.

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Fabrication of an appropriate skin scaffold needs to meet several standards related to the mechanical and biological properties. Fully natural/green scaffolds with acceptable biodegradability, biocompatibility, and physiological properties quite often suffer from poor mechanical properties. Therefore, for appropriate skin tissue engineering and to mimic the real functions, we need to use synthetic polymers and/or additives as complements to green polymers. Green nanocomposites (either nanoscale natural macromolecules or biopolymers containing nanoparticles) are a class of scaffolds with acceptable biomedical properties window (drug delivery and cardiac, nerve, bone, cartilage as well as skin tissue engineering), enabling one to achieve the required level of skin regeneration and wound healing. In this review, we have collected, summarized, screened, analyzed, and interpreted the properties of green nanocomposites used in skin tissue engineering and wound dressing. We particularly emphasize the mechanical and biological properties that skin cells need to meet when seeded on the scaffold. In this regard, the latest state of the art studies directed at fabrication of skin tissue and bionanocomposites as well as their mechanistic features are discussed, whereas some unspoken complexities and challenges for future developments are highlighted.

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“…[29,30] The use of sodium lignosulphonate (SL) as a nanocarrier is of interest in green and sustainable chemistry because of its renewable, biodegradable, biocompatible, and non-toxic properties. [31,32] In addition, its ability to absorb ultra violet (UV) light [33] and antioxidant activity [34] make it a great candidate for pesticide additives. In this study, we designed and synthesized a hybrid core-shell nanostructure based on SL and dodecyl dimethyl benzyl ammonium chloride (DDBAC).…”

Section: Introductionmentioning

confidence: 99%

Core/Shell Dual‐Responsive Nanocarriers via Iron‐Mineralized Electrostatic Self‐Assembly for Precise Pesticide Delivery

Zhang

Wang

et al. 2021

Adv Funct Materials

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It is desirable for a simple and universal method to synthesize stimuli‐responsive nanocarriers to targeted delivery of pesticides. In this study, a novel pH‐value and laccase dual‐responsive nanopesticide system loaded with lambda‐cyhalothrin (LC) is established by iron mineralization after electrostatic self‐assembly between sodium lignosulphonate (SL) and dodecyl dimethyl benzyl ammonium chloride (DDBAC). These nanoparticles are core–shell structures in which iron mineralization plays a key role in stabilizing the nanoparticles. This synthesis strategy is suitable for encapsulating hydrophobic and low‐volatility compounds. The encapsulation of the nanocarriers prolongs the half‐life of the LC under UV irradiation by 4.4‐fold. After irradiation, the mortality of Agrotis ipsilon treated by the LC@SL/DDBAC/Fe is approximately 39% higher than that treated by emulsifiable concentrate (EC) at the concentration of 1 mg L−1. The dual‐responsive property of lignin‐based nanoplatform to alkalinity and laccase enable cargo release on demand. Although the toxicity of EC and LC@SL/DDBAC/Fe to A. ipsilon is similar, that of LC@SL/DDBAC/Fe to Brachydanio rerio is decreased by 11.57‐fold, and the toxicity selective pressure is enhanced by 11‐fold compared with EC. The SL/DDBAC/Fe nanocarriers represent a simple preparation procedure, excellent environmental safety, and dual‐responsive release profiles and can offer a promising nanoplatform for precise pesticide delivery.

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Green and Sustainable Self-Assembly Nanocomposite from Gentamicin Sulfate/Lignosulfonate with Efficient Antibacterial and Wound-Healing Activity

Cited by 25 publications

References 55 publications

Advanced CNC/PEG/PDMAA Semi-IPN Hydrogel for Drug Delivery Management in Wound Healing

Advanced CNC/PEG/PDMAA Semi-IPN Hydrogel for Drug Delivery Management in Wound Healing

Green Polymer Nanocomposites for Skin Tissue Engineering

Core/Shell Dual‐Responsive Nanocarriers via Iron‐Mineralized Electrostatic Self‐Assembly for Precise Pesticide Delivery

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