Greatly Improved Blood Compatibility by Microscopic Multiscale Design of Surface Architectures

Fan, Hua; Chen, Peipei; Qi, Ruomei; Zhai, Jin; Wang, Jingxia; Чэн, Лонг; Chen, Li; Sun, Qingqing; Song, Yanlin; Han, Dong; Jiang, Lei

doi:10.1002/smll.200900345

Cited by 80 publications

(72 citation statements)

References 24 publications

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“…Platelet adhesion assays showed that the resulting surface exhibited good platelet resistance under flow. [79] Milner et al built nanoscale square pillars on a polyether(urethane urea) (PUU) surface and found that at low shear stress platelet adhesion on this surface was significantly suppressed. [80] It has also been suggested that optimization of chemical properties together with topography could provide surfaces with novel functionality.…”

Section: Stimuli-responsive Polymers and Diblock Copolymers For Surfamentioning

confidence: 99%

Surface Modification to Control Protein/Surface Interactions

Lin

et al. 2011

Macromolecular Bioscience

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Protein/surface interactions are well known to play an important role in various biological phenomena and to determine the ultimate biofunctionality of a given material once it is in contact with a biological environment. Control over the interactions between proteins and material surfaces are not only of great theoretical interest but also of crucial importance for many biomedical applications. In this Feature Article, we summarize various successful approaches used in our laboratory and other groups for controlling protein adsorption through chemical modification of the surface and/or the introduction of specific topographic features. Some perspectives on future research in these areas are also presented.

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Section: Stimuli-responsive Polymers and Diblock Copolymers For Surfamentioning

confidence: 99%

Surface Modification to Control Protein/Surface Interactions

Lin

et al. 2011

Macromolecular Bioscience

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“…From the biomimetic viewpoint, a hierarchical structure composed of microand nanoscale components may provide a more suitable surface topography for cell functions as it can better mimic the structure of the natural extracellular matrix. There have been some attempts to fabricate such micro/nanostructures for biomedical applications such as tissue engineering scaffolds [35e38], implant surfaces [39e41], as well as blood-contacting materials [42]. Tan et al have produced micro-and nanoscale structures by depositing nanostructured hydroxyapatite on a microscale architecture created by microfabrication technology and these structures enhances some selective cellular functions [37].…”

Section: Introductionmentioning

confidence: 99%

The influence of hierarchical hybrid micro/nano-textured titanium surface with titania nanotubes on osteoblast functions

Zhao¹,

Mei²,

Chu³

et al. 2010

Biomaterials

414

299

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“…Red blood cells may hemolyze when contacting with implant materials and thus cause eventually failure [34]. Therefore, for evaluating blood compatibility and biocompatibility, it is of vital importance to investigate the hemolysis ratio of the material.…”

Section: Blood Compatibility Of Oriented Plamentioning

confidence: 99%

Fibrillation of chain branched poly (lactic acid) with improved blood compatibility and bionic structure

Zhao

et al. 2015

Chemical Engineering Journal

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Highly-oriented poly (lactic acid) (PLA) with bionic fibrillar structure and micro-grooves was fabricated through solid hot drawing technology for further improving the mechanical properties and blood biocompatibility of PLA as blood-contacting medical devices. In order to enhance the melt strength and thus obtain high orientation degree, PLA was first chain branched with pentaerythritol polyglycidyl ether (PGE). The branching degree as high as 12.69 mol% can be obtained at 0.5wt% PGE content. The complex viscosity, elastic and viscous modulus for chain branched PLA were improved resulting from the enhancement of molecular entanglement, and consequently higher draw ratio can be achieved during the subsequent hot stretching. The stress-induced crystallization of PLA occurred during stretching, and the crystal structure of the oriented PLA can be attributed to the ' crystalline form. The tensile strength and modulus of PLA were improved dramatically by drawing.Chain branching and orientation could significantly enhance the blood compatibility of PLA by prolonging clotting time and decreasing hemolysis ratio, protein adsorption and platelet activation. Fibrous structure as well as micro-grooves can be observed for the oriented PLA which were similar to intimal layer of blood vessel, and this bionic structure was considered to be beneficial to decrease the activation and/or adhesion of platelets.

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Greatly Improved Blood Compatibility by Microscopic Multiscale Design of Surface Architectures

Cited by 80 publications

References 24 publications

Surface Modification to Control Protein/Surface Interactions

Surface Modification to Control Protein/Surface Interactions

The influence of hierarchical hybrid micro/nano-textured titanium surface with titania nanotubes on osteoblast functions

Fibrillation of chain branched poly (lactic acid) with improved blood compatibility and bionic structure

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