The influence of hierarchical hybrid micro/nano-textured titanium surface with titania nanotubes on osteoblast functions

Zhao, Lei; Mei, Shenglin; Chu, Paul K.; Zhang, Yumei; Wu, Zhifen

doi:10.1016/j.biomaterials.2010.03.014

Cited by 414 publications

(326 citation statements)

References 45 publications

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“…In previous studies, a surface roughness of between 13 and 16 nm was found to be optimal for RBM cell culture [18,19]. e nanonetwork structure framed on the titanium disks here was like the hierarchical structure outlined by Zhao et al [12]. In their work, hierarchical nanotextured titanium surface topographies with TNS structures that mirrored the hierarchical structures of bone tissues were created by etching followed by anodization.…”

Section: Discussionmentioning

confidence: 52%

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Analysis of Titania Nanosheet Adsorption Behavior Using a Quartz Crystal Microbalance Sensor

Tashiro

Komasa

Miyake

et al. 2018

Advances in Materials Science and Engineering

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We investigated the adsorption of albumin and fibronectin on a titania nanosheet-(TNS-) modified quartz crystal microbalance (QCM) sensor. A Ti QCM sensor was fabricated by reactive magnetron sputtering. A thin layer of Ti was deposited on the QCM sensor. is sensor was then alkali-modified by treatment with NaOH at room temperature to fabricate the titania nanosheets. Scanning probe microscopy, X-ray photoelectron spectroscopy, and scanning electron microscopy were performed to investigate the surface topology and chemical components of each sensor. e TNS had a titanium oxide film exhibiting a nodular structure and a thickness of 13 nm on the QCM sensor. Furthermore, QCM measurements showed significantly greater amounts of albumin and fibronectin adsorbed on the TNS than on titanium. e NaOH treatment of titanium modified the sensor surface and improved the adsorption behaviors of proteins related to the initial adhesion of bone marrow cells. erefore, we concluded that TNS improves the initial adhesion between the implant materials and the surrounding tissues.

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Section: Discussionmentioning

confidence: 52%

“…Several studies have demonstrated that implant surfaces a ect nanoscale topography and thereby alter cell behaviors or change the nanofeatures of structures to improve the osseointegration process [4,11,12]. e embed surface can be adjusted by various approaches to add nanoscale features to the surfaces in speci c combinations.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Titania Nanosheet Adsorption Behavior Using a Quartz Crystal Microbalance Sensor

Tashiro

Komasa

Miyake

et al. 2018

Advances in Materials Science and Engineering

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“…Third, our BMTs have strategically placed nano-pores. Data from the literature indicate that cells are especially sensitive to nanopatterns 18,19 ; therefore, we expected the nano-pores on the walls of the micro-channels to play a role in increasing cell attachment. Nano-sized pores (100-400 nm) on the surface of the trabecular septa allowed immobilized cells to anchor.…”

Section: Discussionmentioning

confidence: 99%

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Koch

Eisig

et al. 2015

JoVE

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Without an active, thriving cell population that is well-distributed and stably anchored to the inserted template, exceptional bone regeneration does not occur. With conventional templates, the absence of internal micro-channels results in the lack of cell infiltration, distribution, and inhabitance deep inside the templates. Hence, a highly porous and uniformly interconnected trabecular-bone-like template with micro-channels (biogenic microenvironment template; BMT) has been developed to address these obstacles. The novel BMT was created by innovative concepts (capillary action) and fabricated with a sponge-template coating technique. The BMT consists of several structural components: interconnected primary-pores (300-400 µm) that mimic pores in trabecular bone, micro-channels (25-70 µm) within each trabecula, and nanopores (100-400 nm) on the surface to allow cells to anchor. Moreover, the BMT has been documented by mechanical test study to have similar mechanical strength properties to those of human trabecular bone (~3.8 MPa) .The BMT exhibited high absorption, retention, and habitation of cells throughout the bridge-shaped (Π) templates (3 cm height and 4 cm length). The cells that were initially seeded into one end of the templates immediately mobilized to the other end (10 cm distance) by capillary action of the BMT on the cell media. After 4 hr, the cells homogenously occupied the entire BMT and exhibited normal cellular behavior. The capillary action accounted for the infiltration of the cells suspended in the media and the distribution (active migration) throughout the BMT. Having observed these capabilities of the BMT, we project that BMTs will absorb bone marrow cells, growth factors, and nutrients from the periphery under physiological conditions.The BMT may resolve current limitations via rapid infiltration, homogenous distribution and inhabitance of cells in large, volumetric templates to repair massive skeletal defects.

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“…The combination of macro-, micro-, and nanoporous architecture obtained in the surface modified Ti-6Al-4V mesh structures mimicked natural bone-like ECM topography that promotes bone formation at nanoscale (regulating protein conformation and signal transduction) and microscale (impacting initial cell attachment and proliferation) [83,[108][109][110][111][112][113][114][115][116][117]. The unique combination of microporous/nanoporous bioactive titania and interconnected porous architecture of microarc/ anodized titanium alloy mesh structures provided a multimodal surface roughness from nano-to-micro-tomacroscale regime and increased the bioactivity of the asfabricated mesh structure [91,92].…”

Section: Surface Modification Of 3d Printed Structuresmentioning

confidence: 94%

Advancements in three-dimensional titanium alloy mesh scaffolds fabricated by electron beam melting for biomedical devices: mechanical and biological aspects

Nune

Misra

2017

Sci. China Mater.

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We elucidate here the process-structure-property relationships in three-dimensional (3D) implantable titanium alloy biomaterials processed by electron beam melting (EBM) that is based on the principle of additive manufacturing. The conventional methods for processing of biomedical devices including freeze casting and sintering are limited because of the difficulties in adaptation at the host site and difference in the micro/macrostructure, mechanical, and physical properties with the host tissue. In this regard, EBM has a unique advantage of processing patient-specific complex designs, which can be either obtained from the computed tomography (CT) scan of the defect site or through a computeraided design (CAD) program. This review introduces and summarizes the evolution and underlying reasons that have motivated 3D printing of scaffolds for tissue regeneration. The overview comprises of two parts for obtaining ultimate functionalities. The first part focuses on obtaining the ultimate functionalities in terms of mechanical properties of 3D titanium alloy scaffolds fabricated by EBM with different characteristics based on design, unit cell, processing parameters, scan speed, porosity, and heat treatment. The second part focuses on the advancement of enhancing biological responses of these 3D scaffolds and the influence of surface modification on cell-material interactions. The overview concludes with a discussion on the clinical trials of these 3D porous scaffolds illustrating their potential in meeting the current needs of the biomedical industry.

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The influence of hierarchical hybrid micro/nano-textured titanium surface with titania nanotubes on osteoblast functions

Cited by 414 publications

References 45 publications

Analysis of Titania Nanosheet Adsorption Behavior Using a Quartz Crystal Microbalance Sensor

Analysis of Titania Nanosheet Adsorption Behavior Using a Quartz Crystal Microbalance Sensor

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Advancements in three-dimensional titanium alloy mesh scaffolds fabricated by electron beam melting for biomedical devices: mechanical and biological aspects

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