Gray matter abnormalities in opioid-dependent patients: A neuroimaging meta-analysis

Wollman, Scott C; Alhassoon, Omar M.; Hall, Matthew; Stern, Mark J.; Connors, Eric J; Kimmel, Christine L; Allen, Kenneth E.; Stephan, Rick A.; Raduà, Joaquim

doi:10.1080/00952990.2016.1245312

Cited by 83 publications

(53 citation statements)

References 74 publications

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“…On the other hand, multi-drug use might be one of the most important reasons inducing these inconsistencies. Other widely abused addictive substances, such as opiates and marijuana, could induce gray-matter reduction in preand orbitofrontal gyri, insulae and temporal cortex [21,22]. These regions are highly overlapped with previous findings in methamphetamine dependent samples for which the effects of other substances were not excluded explicitly [11,12,16].…”

Section: Discussionmentioning

confidence: 51%

Gray-matter structure in long-term abstinent methamphetamine users

Nie

Zhao

Wen³

et al. 2020

BMC Psychiatry

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Background: Previous studies of brain structure in methamphetamine users have yielded inconsistent findings, possibly reflecting small sample size and inconsistencies in duration of methamphetamine abstinence as well as sampling and analyses methods. Here we report on a relatively large sample of abstinent methamphetamine users at various stages of long-term abstinence. Methods: Chronic methamphetamine users (n = 99), abstinent from the drug ranging from 12 to 621 days, and healthy controls (n = 86) received T1-weighted structural magnetic resonance imaging brain scans. Subcortical and cortical gray-matter volumes and cortical thickness were measured and the effects of group, duration of abstinence, duration of methamphetamine use and onset age of methamphetamine use were investigated using the Freesurfer software package. Results: Methamphetamine users did not differ from controls in gray-matter volumes, except for a cluster in the right lateral occipital cortex where gray-matter volume was smaller, and for regions mainly in the bilateral superior frontal gyrui where thickness was greater. Duration of abstinence correlated positively with gray-matter volumes in whole brain, bilateral accumbens nuclei and insulae clusters, and right hippocampus; and with thickness in a right insula cluster. Duration of methamphetamine use correlated negatively with gray-matter volume and cortical thickness of a cluster in the right lingual and pericalcarine cortex. Conclusions: Chronic methamphetamine use induces hard-to-recover cortical thickening in bilateral superior frontal gyri and recoverable volumetric reduction in right hippocampus, bilateral accumbens nuclei and bilateral cortical regions around insulae. These alternations might contribute to methamphetamine-induced neurocognitive disfunctions and reflect a regional specific response of the brain to methamphetamine.

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Section: Discussionmentioning

confidence: 51%

Gray-matter structure in long-term abstinent methamphetamine users

Nie

Zhao

Wen³

et al. 2020

BMC Psychiatry

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“…Structural imaging studies have largely shown that problematic use of substances, such as cocaine (Rando, Tuit, Hannestad, Guarnaccia, & Sinha, 2013), opioids (Wollman et al, 2017), alcohol (Heikkinen et al, 2017), and cigarettes (Peng et al, 2017), is associated with reduced gray matter volumes in the insular cortex, typically bilaterally. In many cases, these structural differences are especially pronounced in the posterior parts of the insula (Droutman et al, 2015).…”

mentioning

confidence: 99%

Delay discounting mediates the association between posterior insular cortex volume and social media addiction symptoms

Turel

Brevers

et al. 2018

Cogn Affect Behav Neurosci

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Addiction-like symptoms in relation to excessive and compulsive social media use are common in the general population. Because they can lead to various adverse effects, there is a growing need to understand the brain systems and processes that are involved in potential social media addiction. We focus on the morphology of the posterior subdivision of the insular cortex (i.e., the insula), because it has been shown to be instrumental to supporting the maintenance of substance addictions and problematic behaviors. Assuming that social media addiction shares neural similarities with more established ones and consistent with evidence from the neuroeconomics domain, we further examine one possible reason for this association-namely that insular morphology influences one's delay discounting and that this delay discounting contributes to exaggerated preference for immediate social media rewards and consequent addiction-like symptoms. Based on voxel-based morphometry techniques applied to MRI scans of 32 social media users, we show that the gray matter volumes of the bilateral posterior insula are negatively associated with social media addiction symptoms. We further show that this association is mediated by delay discounting. This provides initial evidence that insular morphology can be associated with potential social media addiction, in part, through its contribution to poor foresight and impulsivity as captured by delay discounting.

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“…Although authors controlled for the abstinence period, they did not consider the individual differences regarding heroin use history length. Indeed, we can speculate that few years of heroin addiction correspond to low level of chronicity, representing a protective factor toward structural and functional alterations of brain areas involved in drug addiction [105][106][107]. This, in turn, could influence the tDCS effects.…”

Section: Follow-up Timementioning

confidence: 98%

Transcranial Direct Current Stimulation to Prevent and Treat Surgery-Induced Opioid Dependence: A Systematic Review

Gallucci

Lucena

Martens³

et al. 2018

Pain Manag.

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Opioid misuse leading to dependence is a major health issue. Recent studies explored valid alternatives to treat pain in postsurgical settings. This systematic review aims to discuss the role of transcranial direct current stimulation (tDCS) in preventing and treating postoperative pain and opioid dependence. PubMed and Embase databases were screened, considering studies testing tDCS effects on pain and opioid consumption in surgical settings and opioid addiction. Eight studies met our inclusion criteria. Results showed a reduction of postoperative pain, opioid consumption and cue-induced craving following cortical stimulation. Despite the limited number of studies, this review shows preliminary encouraging evidence regarding the analgesic role of tDCS. However, future studies are needed to further investigate the application of tDCS in postsurgical settings.

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Gray matter abnormalities in opioid-dependent patients: A neuroimaging meta-analysis

Cited by 83 publications

References 74 publications

Gray-matter structure in long-term abstinent methamphetamine users

Gray-matter structure in long-term abstinent methamphetamine users

Delay discounting mediates the association between posterior insular cortex volume and social media addiction symptoms

Transcranial Direct Current Stimulation to Prevent and Treat Surgery-Induced Opioid Dependence: A Systematic Review

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