Graves' disease in HTLV-I carriers

Kawai, Hisaomi; Yokoi, Kenji; Akiyama, Masashi; Kunishige, Makoto; Abé, Masakazu; Tanouchi, Y; Mine, Hideki; Mimura, Yoshihiro; Saito, Shiro

doi:10.1007/bf00270582

Cited by 14 publications

(8 citation statements)

References 22 publications

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“…HTLV-1 associated uveitis (HAU) has since been reported in Brazil and Martinique [59,130]. HAU occurs in patients with other HTLV-1 associated inflammatory conditions such as HAM/TSP [131] and Graves' disease/autoimmune thyroiditis [132][133][134]. Two cases of HAU have been reported in association with tubulointerstitial nephritis [52].…”

Section: Htlv-1 Associated Uveitismentioning

confidence: 99%

Inflammatory manifestations of HTLV-1 and their therapeutic options

Martin

Taylor

Jacobson

2014

Expert Review of Clinical Immunology

104

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Human T lymphotropic virus type 1 (HTLV-1) is one of the most intriguing retroviruses infecting humans. Most commonly, infection remains undetected, since it does not cause obvious harm, yet in 4-9% of patients, this infection can be devastating, causing adult T-cell leukemia/lymphoma and/or HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). This review concentrates on all inflammatory aspects of HTLV-1 infection: HAM/TSP, HTLV-1 associated uveitis, HTLV-1 associated conjunctivitis, sicca syndrome and interstitial keratitis, HTLV-1 associated Sjö gren's syndrome, Hashimoto's thyroiditis and Graves' disease, HTLV-1 associated pulmonary disease, infective dermatitis associated with HTLV-1, HTLV-1 associated inflammatory myositis and HTLV-1 associated arthritis. With the exception of HAM/TSP treatment, studies of these conditions are sparse and even for HAM/TSP, the level of evidence is limited. While control or elimination of infection remains a goal, most therapy beyond symptomatic management is directed at the immune response to HTLV-1.

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Section: Htlv-1 Associated Uveitismentioning

confidence: 99%

Inflammatory manifestations of HTLV-1 and their therapeutic options

Martin

Taylor

Jacobson

2014

Expert Review of Clinical Immunology

104

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“…Serum HTLV-I antibody is found in 6% of patients with GD, 7% of patients with chronic thyroiditis, and 2% of patients with nodular goiter[ 60 ]. Beside the fact that anti-HLTV-I antibody and proviral DNA is detected in peripheral lymphocytes of patients with GD [ 60 , 61 ], proviral load in HTLV-I-infected patients with GD, as observed in Hashimoto's thyroiditis, is significantly higher than in asymptomatic HTLV-I carriers [ 57 ]. GD and HTLV-I infection seem to be interacting and resulting in onset of uveitis [ 61 , 62 ].…”

Section: Introductionmentioning

confidence: 99%

“…Beside the fact that anti-HLTV-I antibody and proviral DNA is detected in peripheral lymphocytes of patients with GD [ 60 , 61 ], proviral load in HTLV-I-infected patients with GD, as observed in Hashimoto's thyroiditis, is significantly higher than in asymptomatic HTLV-I carriers [ 57 ]. GD and HTLV-I infection seem to be interacting and resulting in onset of uveitis [ 61 , 62 ]. Indeed, 5% of HTLV-I-positive patients with GD developed uveitis, whereas none of the HTLV-I negative patients with GD nor HTLV-I-positive patients with chronic thyroiditis or nodular goiter developed uveitis [ 60 ].…”

Section: Introductionmentioning

confidence: 99%

Viruses and thyroiditis: an update

Desailloud

Hober

2009

Virol J

383

326

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Viral infections are frequently cited as a major environmental factor involved in subacute thyroiditis and autoimmune thyroid diseases This review examines the data related to the role of viruses in the development of thyroiditis.Our research has been focused on human data. We have reviewed virological data for each type of thyroiditis at different levels of evidence; epidemiological data, serological data or research on circulating viruses, direct evidence of thyroid tissue infection. Interpretation of epidemiological and serological data must be cautious as they don't prove that this pathogen is responsible for the disease. However, direct evidence of the presence of viruses or their components in the organ are available for retroviruses (HFV) and mumps in subacute thyroiditis, for retroviruses (HTLV-1, HFV, HIV and SV40) in Graves's disease and for HTLV-1, enterovirus, rubella, mumps virus, HSV, EBV and parvovirus in Hashimoto's thyroiditis. However, it remains to determine whether they are responsible for thyroid diseases or whether they are just innocent bystanders. Further studies are needed to clarify the relationship between viruses and thyroid diseases, in order to develop new strategies for prevention and/or treatment.

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“…Other physiopathological explanations could be: (1) virus‐induced immunomodulation of CD4 + T cells that control B cells secreting anti‐AChR antibodies; and (2) direct virus‐induced polyclonal activation of B cells driving the secretion of AChR antibodies. Interestingly, an association between HTLV‐I and other autoimmune diseases, such as diabetes5 and thyroid diseases,4, 16 has been described. The patient studied herein had a history of diabetes and hypothyroidism although no specific auto‐antibodies were detected.…”

Section: Discussionmentioning

confidence: 99%

Myasthenia gravis associated with HTLV‐I infection and atypical brain lesions

2006

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We report a patient who experienced progressive diplopia and distal weakness of the upper limbs. Magnetic resonance imaging of the brain showed extensive white matter lesions and analysis of cerebrospinal fluid revealed acute human T-lymphotropic virus type I (HTLV-I) infection. Myasthenia gravis (MG) was evidenced by electromyography (EMG) and antibodies against acetylcholine receptor. This unusual case of MG associated with HTLV-I infection and brain-restricted lesions underscores the possible link between viruses and MG pathogenesis.

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Graves' disease in HTLV-I carriers

Cited by 14 publications

References 22 publications

Inflammatory manifestations of HTLV-1 and their therapeutic options

Inflammatory manifestations of HTLV-1 and their therapeutic options

Viruses and thyroiditis: an update

Myasthenia gravis associated with HTLV‐I infection and atypical brain lesions

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