Gravacridondiolacetate, A New Dihydrofuroacridone Alkaloid fromRuta graveolens

Algicidal and antifungal compounds from the roots of Ruta graveolens and synthesis of their analogs

“…The separation of a weakly active column fraction, led to the isolation of another active constituent, which was identified as gravacridondiol (2) by analysis of its NMR and mass spectra (Paulini et al, 1991;Bergenthal et al, 1979). The results of the bioassay indicated that 2 was 100· less active than 1 against O. perornata (Table 1).…”

“…This was crystallized from MeOH and CH 2 Cl 2 to afford dark yellow crystals (28 mg). The identity of the compound was established by comparison of 1 H and 13 C NMR spectroscopic data with those reported in the literature (Paulini et al, 1991;Bergenthal et al, 1979).…”

“…The identity of the compound was established by comparison of 1 H and 13 C NMR spectroscopic data with those reported in the literature (Paulini et al, 1991;Bergenthal et al, 1979). CD (c = 5.8 · 10 À5 , CHCl 3 ): [h] 268 À6.4 · 10 5 , [h] 275 À8.1 · 10 5 , [h] 330 À3.5 · 10 5 .…”

Specific accumulation and revised structures of acridone alkaloid glucosides in the tips of transformed roots of Ruta graveolens

“…Nearly 20 acridone alkaloids have been isolated so far from intact plants and from various cell and root cultures of Ruta graveolens Rozsa et al, , 1981Eilert et al, 1982;Gro¨ger, 1988;Paulini et al, 1991). Several cell and root culture lines were established in our laboratory (Kuzovkina et al, 1979(Kuzovkina et al, , 1980Kuzovkina, 1992) and, in addition to phytochemical studies, used for investigations of biosynthetic pathways and enzymes.…”

Alkaloids and Coumarins from Ruta Species

“…A variety of the same species, namely R. chalepensis var. latifolia Salisb., has yielded a new alkaloid 5-methoxydictamnine (36), together with kokusaginine (9), dictamnine (28), 1-hydroxy-Nmethylacridone (16), graveoline (29) and graviolenine (37) [15]. From the same plant, two shikimic acid derivatives, the known compound moskachan D (38) and a new compound, dehydromoskachan C (39), were isolated [16].…”