Graphene reinforced radiation crosslinked polyvinyl alcohol/carboxymethyl cellulose nanocomposites for controlled drug release

Abstract

This study reports development of graphene reinforced nanocomposites of carboxymethyl cellulose and polyvinyl alcohol for controlled drug release applications. The nanocomposites were synthesized through solution blending coupled with sonication assisted dispersion. The matrices were crosslinked to different extent by imparting different high energy radiation doses. The elastic modulus of the polymer nanocomposites increased by fourfold with the increase in graphene content from 1 to 3 wt% with no further significant change in elastic modulus at higher graphene content. The crystalline content did not change with addition of graphene and was 40% for all nanocomposites. Addition of 3 wt% graphene marginally increased the time for 60% drug release (T 60 ). However, T 60 increased by 100% with an increase in radiation dose from 25 to 150 kGy, suggesting absorbed radiation dose to be a critical factor for graphene based nanocomposites for controlled drug release applications. POLYM. COMPOS., 38:E74-E80, 2017.

Design of moxifloxacin encapsulated network hydrogel wound dressings: Evaluation of polymer‐drug, polymer‐blood, and polymer‐bio membrane interactions

“…[ 57 ] The incorporation of silk fibroin has improved the mechanical strength properties of the CMC/gelatin blend film and these films indicated the interection of the structure with the skin for better wound care applications. [ 58 ] The literature reports [ 59–64 ] and present research work indicated that the present material (AIG‐cl‐carbopol‐co‐poly(AAm) polymers) formed in the form of hydrogel films can act as potential wund dressing materials.…”

Dependence of Electrical Conductivity on Phase Morphology for Graphene Selectively Located at the Interface of Polypropylene/Polyethylene Composites

“…A further increase in the PP content to 40 wt% resulted in a remarkable improvement in the electrical conductivity of the composite, about seven times greater than that of the 30 wt% PP composites, indicating that the TRG percolated networks were well developed for efficient electron transport. This significant improvement in electrical conductivity could be attributed to the fact that the TRG/PP/PE composites formed a co-continuous phase structure at a PP/PE weight ratio of 40/60 (Figure 4b), which caused a superior volume-exclusion effect of the PP [27]. Furthermore, greatly reducing the PE content from 100 to 60 wt% caused a significant increase in the nominal concentration of TRG in the PE phase, which allowed the TRG to form a better-percolated conductive network throughout the PE phase at the same overall loading of TRG.…”

Preparation and characterization of carboxymethyl cellulose/polyethylene glycol films containing bromelain/curcumin: In vitro evaluation of wound healing activity

“…16 In nature, the carbohydrate polymer cellulose is widespread. 17 The advantages of these materials include biocompatibility, biodegradability, solubility in water, resources, cost-effectiveness, and environmental friendliness. For a period of time, CMC has been used as an organic material in hydrogels due to its high carboxymethyl group concentration on the cellulose backbone.…”

“…Cellulose and its derivatives are commonly used as natural substitutes to natural polymers in a variety of fields of study, including wound dressing, delivery of pharmaceuticals, and tissue engineering 16 . In nature, the carbohydrate polymer cellulose is widespread 17 . The advantages of these materials include biocompatibility, biodegradability, solubility in water, resources, cost‐effectiveness, and environmental friendliness.…”