Design of moxifloxacin encapsulated network hydrogel wound dressings: Evaluation of polymer‐drug, polymer‐blood, and polymer‐bio membrane interactions

Abstract

It is an exploration of the inherent wound-healing tendency of Azadirachta indica gum (AIG) or neem gum polysaccharides to develop the hydrogel wound dressings with enhanced potential during wound management. Herein this research work, antibiotic moxifloxacin encapsulated AIG network copolymeric hydrogels were developed by functionalizing with carbapol and poly(acrylamide) [poly(AAm)] for better wound healing. The polymer-drug, polymer-blood, and polymer-bio membrane interactions were evaluated in biomedical properties. The copolymeric network structure was confirmed by scanning electron micrographs (SEMs), atomic force microscopy (AFM), Fourier transform infrared spectroscopy (FTIR), and 13 C solid-state nuclear magnetic resonance (NMR) spectroscopy. The results confirmed sustained release of the moxifloxacin with diffusion by non-Fickian process and Korsmeyer-Peppas kinetic model in the phosphate buffer saline (PBS). These interactions inferred the blood-compatible (hemolytic index 3.41 ± 0.70%) and mucoadhesive nature (polymer-biomembrane detachment force 0.09 ± 0.01 mN) of hydrogel dressing. The per gram of hydrogel dressings absorbed 10.22 ± 0.23 g of simulated wound fluid which is very useful to maintain moist wound environment for better wound healing. All these interactions and properties indicated the suitability of the hydrogel material for wound dressing applications for better wound care.

Multiple-Language-Responsive Conductive Hydrogel Composites for Flexible Strain and Epidermis Sensors

“…As given in Figure S3, the peaks at 2916 and 2848 cm −1 were assigned due to the stretching vibrations of −CH 3 and −CH 2 , respectively, while the peaks at 1652 and 1602 cm −1 represent the stretching and bending vibrations of �C� O and �N�H, respectively. 34 The peak at 3362 cm −1 was the characteristic peak of −NH 2 in CNTs0, and after the addition of F-CNTs a red shift was observed for the CNTs2 having the wavenumber value of 3347 cm −1 . This shift was more prominent in CNTs4 with a value of 3338 cm −1 .…”

Inorganic metal salts as additives in the design of cellulose/arabinogalactan hydrogels for prolonged delivery of simvastatin in simulated bio‐fluids

“…2 The resulting interpenetrating network (IPN) has received a lot of interest since it allows us to combine the advantageous qualities of each polymeric component of the IPNs, resulting in a novel system with properties that frequently differ from those of single components. 3 The synthesis of such polymeric networks using various combinations of polymers such as poly(acrylic acid)/linseed mucilage/chitosan, 4 carboxylated xanthan-carboxylated guar gum, 5 carbapol and poly(acrylamide)-functionalized Azadirachta indica gum, 6 cellulose acetate-poly(acrylic) acid, 7 sodium alginate/chitosan, 8 and polyacrylamide/chitosan/polypyrrole 9 is reported in the literature for controlled drug release applications. Various polysaccharide hydrogels, including but not limited to gellan gum, 10,11 chitosan, 12,13 alginate, 14 hyaluronic acid, 15 and carboxymethyl cellulose 16,17 were also developed for tissue engineering applications.…”