Graphene quantum dots in photodynamic therapy

Chen, Jiayi; Wu, Wentian; Zhang, Fangwei; Zhang, Jiali; Liu, Hui; Zheng, Jing; Guo, Shouwu; Zhang, Jingyan

doi:10.1039/d0na00631a

Cited by 31 publications

(34 citation statements)

References 40 publications

(117 reference statements)

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Section: Carbon-based Materials (Cbm) Applied In Photodynamic (Pdt) and Photothermal (Ptt) Therapiesmentioning

confidence: 99%

“…It is worth noting that the performance of GQDs in PDT might be associated with its specific structural features. Chen et al (2020) examined the photoactivity of single-atomiclayered GQDs under laser and halogen irradiation, demonstrating a null generation of 1 O2, which was attributed to its particular morphology[96].On the other hand, regarding the doping of GQDs, it has been considered to improve its phototherapy performance. Elements like sulfur and nitrogen have been employed to achieve this aim.…”

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confidence: 99%

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Carbon-Based Materials in Photodynamic and Photothermal Therapies Applied to Tumor Destruction

Lagos

Buzzá

Bagnato

et al. 2021

IJMS

123

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Within phototherapy, a grand challenge in clinical cancer treatments is to develop a simple, cost-effective, and biocompatible approach to treat this disease using ultra-low doses of light. Carbon-based materials (CBM), such as graphene oxide (GO), reduced GO (r-GO), graphene quantum dots (GQDs), and carbon dots (C-DOTs), are rapidly emerging as a new class of therapeutic materials against cancer. This review summarizes the progress made in recent years regarding the applications of CBM in photodynamic (PDT) and photothermal (PTT) therapies for tumor destruction. The current understanding of the performance of modified CBM, hybrids and composites, is also addressed. This approach seeks to achieve an enhanced antitumor action by improving and modulating the properties of CBM to treat various types of cancer. Metal oxides, organic molecules, biopolymers, therapeutic drugs, among others, have been combined with CBM to treat cancer by PDT, PTT, or synergistic therapies.

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Section: Carbon-based Materials (Cbm) Applied In Photodynamic (Pdt) and Photothermal (Ptt) Therapiesmentioning

confidence: 99%

mentioning

confidence: 99%

Carbon-Based Materials in Photodynamic and Photothermal Therapies Applied to Tumor Destruction

Lagos

Buzzá

Bagnato

et al. 2021

IJMS

123

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“…Moreover, PDT also uses nanotechnology where photosensitizers are modified by adding quantum dots to the system, which also seems to be a great solution [ 248 ]. It connects to a photosensitizer, and the task of quantum dots is to target and deliver photosensitizers directly to cells, providing additional enhancement in drug transport to the desired therapeutic area [ 249 ].…”

Section: Why Are Hyperthermia and Pdt Used In Treatment? Why Are They A Good Option For Combination Treatment?mentioning

confidence: 99%

Photodynamic Therapy and Hyperthermia in Combination Treatment—Neglected Forces in the Fight against Cancer

et al. 2021

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Cancer is one of the leading causes of death in humans. Despite the progress in cancer treatment, and an increase in the effectiveness of diagnostic methods, cancer is still highly lethal and very difficult to treat in many cases. Combination therapy, in the context of cancer treatment, seems to be a promising option that may allow minimizing treatment side effects and may have a significant impact on the cure. It may also increase the effectiveness of anti-cancer therapies. Moreover, combination treatment can significantly increase delivery of drugs to cancerous tissues. Photodynamic therapy and hyperthermia seem to be ideal examples that prove the effectiveness of combination therapy. These two kinds of therapy can kill cancer cells through different mechanisms and activate various signaling pathways. Both PDT and hyperthermia play significant roles in the perfusion of a tumor and the network of blood vessels wrapped around it. The main goal of combination therapy is to combine separate mechanisms of action that will make cancer cells more sensitive to a given therapeutic agent. Such an approach in treatment may contribute toward increasing its effectiveness, optimizing the cancer treatment process in the future.

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Section: Graphene Quantum Dots (Gqds)mentioning

confidence: 99%

“…It is worth noting that the performance of GQDS in PDT might be associated with its specific structural features. Chen et al (2020) examined the photoactivity of single-atomic-layered GQDs under laser and halogen irradiation, demonstrating a null generation of 1 O2, which was attributed to its particular morphology[96].On the other hand, regarding the doping of GQDs, it has been considered to improve its phototherapy performance. Elements like sulfur and nitrogen have been employed to achieve this aim.…”

mentioning

confidence: 99%

Carbon-Based Materials in Photodynamic and Photothermal Therapies Applied to Tumor Destruction

Lagos¹,

Buzzá²,

Bagnato³

et al. 2021

Preprint

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Within phototherapy, a grand challenge in clinical cancer treatments is to develop a simple, cost-effective, and biocompatible approach to treat this disease using ultra-low doses of light. Carbon-based materials (CBM), such as graphene oxide (GO), reduced GO (r-GO), graphene quantum dots (GQDs), and carbon dots (C-DOTs), are rapidly emerging as a new class of thera-peutic materials against cancer. This mini-review summarizes the progress in lasts years re-garding the applications of CBM in photodynamic (PDT) and photothermal (PTT) therapies for tumor destruction. The current understanding of the performance of modified CBM, hybrids and composites, is also addressed. This approach seeks to achieve an enhanced healing action by im-proving and modulating the properties of CBM to treat various types of cancer. Metal oxides, organic molecules, biopolymers, therapeutic drugs, among others, have been combined with CBM to treat cancer by PDT, PTT, or synergistic therapies.

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Graphene quantum dots in photodynamic therapy

Abstract: Single-atomic-layered graphene quantum dots with lateral sizes of ∼5 and 20 nm are not photosensitizers for photodynamic therapy.

Cited by 31 publications

References 40 publications

Carbon-Based Materials in Photodynamic and Photothermal Therapies Applied to Tumor Destruction

Carbon-Based Materials in Photodynamic and Photothermal Therapies Applied to Tumor Destruction

Photodynamic Therapy and Hyperthermia in Combination Treatment—Neglected Forces in the Fight against Cancer

Carbon-Based Materials in Photodynamic and Photothermal Therapies Applied to Tumor Destruction

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